Smart Delivery Systems Based on Poly(glycidyl methacrylate)s‐Coated Organic/Inorganic Core–Shell Nanohybrids

Abstract

Smart delivery systems have gained momentum over the last few decades due to their potential to realize enhanced therapeutic efficacy. Poly(glycidyl methacrylate)s (PGMAs), which spring up like mushrooms, have drawn great attention in the theranostics field, especially in multifunctional theranostic systems. The marriage of PGMAs with functional inorganic cores is expected to integrate diagnosis (e.g., fluorescence, X‐ray computed tomography, magnetic resonance, photoacoustic and upconversion luminescence imaging), treatment, or multimodal synergistic therapies (e.g., chemotherapy, gene therapy, photothermal therapy) in one pot for personalized medicine. In this review, recent progress in various PGMA‐coated nanohybrids based on the type of integrated inorganic nanoparticle, including silica nanoparticles, magnetic nanoparticles, quantum dots, gold nanoparticles, gold nanorods, metal‐organic frameworks, cellulose nanocrystals, and their core‐shell nanostructures is systematically reviewed. Future work in this field is anticipated to be devoted to developing efficient real‐time‐imaging‐guided multimodal synergistic therapies.

Synthesis and functionalization of zinc phosphate@polyglycidyl methacrylate composites for antimicrobial drug immobilization and controlled release: an in vitro study

“…Several literature studies involving ZnPNPs and ZnP-containing nanocomposites reveal that ZnP exhibits less cytotoxicity inside a biological system than other inorganic nanoparticles. [80][81][82] In this case, it is presumed that the PGMA polymer coating has a vital influence on reducing ZnP's cytotoxic effects which support the result published by Tan et al 83 CFX-loaded ZnP@PGMA-DETA and ZnP@PGMA-Cys composites showcase clear zone areas inside the BC (+) agar plates. Here, the zone of inhibition diameters are approximately 25-26 mm at pH 7.4 and 5.5.…”

Dual Sensitization via Electron and Energy Harvesting in a Nanohybrid for Improvement of Therapeutic Efficacy

“…In the case of Rf− ZnO and Rf−ZnO−Au, the change in the absorbance peak at 445 nm indicates the complex formation between Rf and the surfaces of both ZnO and Au−ZnO, as shown in Figure 2a. 17,28 The absorption spectra of Au−ZnO possess two characteristic peaks of Au and ZnO at 536 and 369 nm, respectively. No distinct peak of Rf is observed in both nanohybrids due to a very low concentration of Rf and significant scattering of the NPs.…”

“…Moreover, sensitization of drugs by inorganic NPs through formulation of a nanohybrid is key for the enhancement of drug activity . In recent years, a variety of nanohybrids have been used to deliver drugs and biomolecules to achieve satisfying therapeutic effects. − Among all, ZnO-based nanohybrids are most promising in terms of modulation of drug activity, disease site-specific targeted delivery, and less toxicity …”

Strategies to improve the photothermal capacity of gold-based nanomedicines

“…The silica is a chemically inert and biocompatible material that can improve the colloidal stability of gold nanostructures [99] . The inclusion of silica derivatives, such as mesoporous silica, can also increase the drug loading capacity of gold nanoparticles [100] . Further, the silica NIR light transparency does not impact the excitation of gold cores during the PTT [101] .…”