Microfluidic and Nanofluidic Resistive Pulse Sensing: A Review

Song, Yongxin; Zhang, Junyan; Li, Dongqing

doi:10.3390/mi8070204

Cited by 58 publications

(48 citation statements)

References 148 publications

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“…Tunable resistive pulse sensing can also be used to investigate adsorbed protein layers on nanoparticles by individual particle size measurement 119 , which is not possible using conventional techniques such as dynamic light scattering due to the formation of agglomerates. It should be noted that the sensitivity and throughput of resistive pulse sensing is still improving, especially with the integration of micro-and nano-fabrication technologies 120 . Figure 9.…”

Section: Direct Analysis Of Nanoparticle Suspensionsmentioning

confidence: 99%

Nanoparticle heterogeneity: an emerging structural parameter influencing particle fate in biological media?

et al. 2019

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Section: Direct Analysis Of Nanoparticle Suspensionsmentioning

confidence: 99%

Nanoparticle heterogeneity: an emerging structural parameter influencing particle fate in biological media?

et al. 2019

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“…The detection and analysis of single molecules with nanopipettes relies on the principle of resistive pulse sensing. [7,11,12] The single-molecule sensitivity of this approach has led to the adoption of nanopipettes in many label-free and carrier-based single biomolecule detection, delivery and biosensing applications. [8][9][10] This field drives the molecule of interest through the nanopipette pore, which, if is of similar size as the Stokes diameter of the molecules, results in a short but easily detectable pulse in an otherwise steady ionic current.…”

Section: Introductionmentioning

confidence: 99%

Analysis of 2D DNA Origami with Nanopipettes

et al. 2018

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Nanopipettes are a useful tool for the detection and analysis of biological molecules at the single-molecule level. Here, we employ nanopipettes fabricated from glass capillaries to identify differently structured 2D DNA origami through the distinctive amplitude and dwell time of the ion current peak resulting from the translocation of the origami through the nanopipette pore. We demonstrate that the ion current peak originating from frame-like DNA origami comprises two individual peaks in contrast to solid tiles of similar size that only lead to a single peak in the ion current. Interestingly, the fine details of the shape of the double-peak characteristic of the translocation of DNA origami frames are correlated with the structural features of the DNA origami. In particular, the size of the central cavity governs the lag time between the two constituent peaks of the double-peak. This work demonstrates the ability of glass nanopipettes to identify and characterize differently structured DNA origami of similar size, advancing the potential of nanopipettes for high-sensitivity single-molecule studies.

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“…Detailed reviews about impedance pulse sensing can be found from other review papers. 41,[59][60][61][62][63] Despite the differences in analyte recognition principles, if an electrical biomarker sensing array is used, each array needs to differentiate signals from individual sensors/sensing channels via signal processing/multiplexing strategies. In this paper, we focus on reviewing various multiplexing strategies (i.e., spatial/time/frequency/codes/particle-based multiplexing) aiming at detection of various biomarkers (i.e., nuclear acids, macromolecular biomarkers/proteins, and cells).…”

Section: Electrical Biomarker Detection Methodsmentioning

confidence: 99%

Lab-on-a-chip electrical multiplexing techniques for cellular and molecular biomarker detection

Liu

Zhe

2018

Biomicrofluidics

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Signal multiplexing is vital to develop lab-on-a-chip devices that can detect and quantify multiple cellular and molecular biomarkers with high throughput, short analysis time, and low cost. Electrical detection of biomarkers has been widely used in lab-on-a-chip devices because it requires less external equipment and simple signal processing and provides higher scalability. Various electrical multiplexing for lab-on-a-chip devices have been developed for comprehensive, high throughput, and rapid analysis of biomarkers. In this paper, we first briefly introduce the widely used electrochemical and electrical impedance sensing methods. Next, we focus on reviewing various electrical multiplexing techniques that had achieved certain successes on rapid cellular and molecular biomarker detection, including direct methods (spatial and time multiplexing), and emerging technologies (frequency, codes, particle-based multiplexing). Lastly, the future opportunities and challenges on electrical multiplexing techniques are also discussed.

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Microfluidic and Nanofluidic Resistive Pulse Sensing: A Review

Cited by 58 publications

References 148 publications

Nanoparticle heterogeneity: an emerging structural parameter influencing particle fate in biological media?

Nanoparticle heterogeneity: an emerging structural parameter influencing particle fate in biological media?

Analysis of 2D DNA Origami with Nanopipettes

Lab-on-a-chip electrical multiplexing techniques for cellular and molecular biomarker detection

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