Microextraction for ambient ionization mass spectrometry analysis

Liu, Yijing; Shang, Yuhan; Ma, Qiang

doi:10.1016/j.sampre.2022.100029

Cited by 4 publications

(2 citation statements)

References 126 publications

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“…20,21 SPE and AIMS techniques are valuable complementary strategies to MS analytical methods for reducing sample complexity and matrix interference. 22 To our knowledge, SPE was used just offline and applied to environmental monitoring, forensic chemistry, and food safety; 23,24 however, online SPE coupling with AIMS could be a powerful analytical system with the potential to minimize runtime analysis and the environmental impact.…”

Section: Introductionmentioning

confidence: 99%

Caffeine quantification in dietary supplements using high-throughput on-line solid phase extraction coupled to Venturi easy ambient sonic-spray ionization mass spectrometry

Tega,

Campos Oliveira,

Ferreira

et al. 2024

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

Caffeine quantification in dietary supplements using high-throughput on-line solid phase extraction coupled to Venturi easy ambient sonic-spray ionization mass spectrometry

Tega,

Campos Oliveira,

Ferreira

et al. 2024

Anal. Methods

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“…Mass spectrometry performance has been greatly improved with the advances in atmospheric pressure ionization techniques, − such as easy sample introduction, simplicity, and high analytical frequency. , Ambient ionization techniques (AITs) made the process even less aggressive because they operate in open air, which promotes minimal sample modifications . Thus, several AITs have been developed to desorb/ionize the molecules directly from solid or liquid samples dispersed on solid supports, like desorption electrospray ionization (DESI), direct analysis in real time (DART), easy ambient sonic spray ionization (EASI), extractive electrospray ionization (EESI), paper spray mass spectrometry, among others.…”

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confidence: 99%

Magnetic Particle Spray Mass Spectrometry

Venga Mendes,

Figueiredo

2024

Anal. Chem.

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In this work, the concept of magnetic particle spray mass spectrometry (MPS-MS) is reported for the first time. Magnetic sorbent particles are used to extract the analytes from a liquid sample. The particles are magnetically attracted to the tip of a magnetic probe that is positioned at the entrance of the mass spectrometer. A solvent is dispensed on the particles, and a high voltage promotes the formation of the Taylor cone around the particles agglomerate. Analytes are desorbed by the solvent, ionized, and analyzed by mass spectrometry. MPS-MS is totally in consonance with the green chemistry principle. A minimal consumption of sample (100 μL), solvent (34 μL), and magnetic sorbent (500 μg) is needed per analysis for an excellent performance of MPS-MS in terms of sensitivity and selectivity. The determination of amitriptyline, citalopram, clomipramine, chlorpromazine, doxepin, haloperidol, nortriptyline, and venlafaxine in human plasma samples using magnetic restricted-access carbon nanotubes was carried out as a proof of principle. Limits of quantification of 10 μg L −1 and correlation coefficients higher than 0.98 were obtained for all of the analytes. Limits of detection ranged from 0.43 to 2.82 μg L −1 . Precision (as relative standard deviation) and accuracies (as relative error) ranged from 3.6 to 23.6%, as well as −12.8 to 18.7%, respectively. MPS-MS opens a new line of developments in the association of sample preparation with ambient ionization. New sorbents, device configurations, and physical and chemical conditions can also be analyzed for the analysis of many other analytes in different samples.

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