Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing

Chen, Yihang; Zhang, Shiming; Cui, Qingyu; Ni, Jiahua; Wang, Xiaochen; Cheng, Xuanbing; Alem, Halima; Tebon, Peyton; Xu, Chun; Guo, Changliang; Nasiri, Rohollah; Moreddu, Rosalia; Yetisen, Ali K.; Ahadian, Samad; Ashammakhi, Nureddin; Jucaud, Vadim; Dokmeci, Mehmet R.; Khademhosseini, Ali

doi:10.1039/d0lc00446d

Cited by 38 publications

(37 citation statements)

References 31 publications

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“…[155] Further composite material approaches include the integration of micro-or nanoparticles into the hydrogel matrix and the addition of fluorescent or chromogenic components for optical detection. [148,[156][157][158] Many bioreceptors were immobilized into or onto the matrix for the detection of a specific target. Such bioassays have wide applications as diagnostic tools in healthcare, and they have traditionally been performed by laboratory methods (e.g., PCR or ELISA).…”

Section: Discussionmentioning

confidence: 99%

Hydrogels and Their Role in Biosensing Applications

Herrmann

Haag

Schedler

2021

Adv Healthcare Materials

175

132

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Hydrogels play an important role in the field of biomedical research and diagnostic medicine. They are emerging as a powerful tool in the context of bioanalytical assays and biosensing. In this context, this review gives an overview of different hydrogels and the role they adopt in a range of applications. Not only are hydrogels beneficial for the immobilization and embedding of biomolecules, but they are also used as responsive material, as wearable devices, or as functional material. In particular, the scientific and technical progress during the last decade is discussed. The newest hydrogel types, their synthesis, and many applications are presented. Advantages and performance improvements are described, along with their limitations.

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Section: Discussionmentioning

confidence: 99%

Hydrogels and Their Role in Biosensing Applications

Herrmann

Haag

Schedler

2021

Adv Healthcare Materials

175

132

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“…The electronic sensors incorporated into the lenses can be interconnected using 3D-printed components [ 147 ]. 3D-printed molds can also be employed to create microchannels in the hydrogel found in smart contact lenses [ 148 ]. Alam et al also described 3D printing of an entire smart contact lens with embedded diagnostic sensors [ 149 ].…”

Section: Methodsmentioning

confidence: 99%

3D Printing in Eye Care

2021

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Three-dimensional printing enables precise modeling of anatomical structures and has been employed in a broad range of applications across medicine. Its earliest use in eye care included orbital models for training and surgical planning, which have subsequently enabled the design of custom-fit prostheses in oculoplastic surgery. It has evolved to include the production of surgical instruments, diagnostic tools, spectacles, and devices for delivery of drug and radiation therapy. During the COVID-19 pandemic, increased demand for personal protective equipment and supply chain shortages inspired many institutions to 3D-print their own eye protection. Cataract surgery, the most common procedure performed worldwide, may someday make use of custom-printed intraocular lenses. Perhaps its most alluring potential resides in the possibility of printing tissues at a cellular level to address unmet needs in the world of corneal and retinal diseases. Early models toward this end have shown promise for engineering tissues which, while not quite ready for transplantation, can serve as a useful model for in vitro disease and therapeutic research. As more institutions incorporate in-house or outsourced 3D printing for research models and clinical care, ethical and regulatory concerns will become a greater consideration. This report highlights the uses of 3D printing in eye care by subspecialty and clinical modality, with an aim to provide a useful entry point for anyone seeking to engage with the technology in their area of interest.

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“…[3] Microfluidic contact lenses have thus attracted particular interest in the last few years, due to their potential of allowing on-eye, real-time tear fluid processing. [7][8][9][10] The crucial advantages lie on the reduced contamination risks compared to current methods, fast analysis times at point-of-care settings, and the possibility of achieving continuous monitoring. [9,11,12] Recent studies report the development of enhanced contact lens devices.…”

Section: Introductionmentioning

confidence: 99%

“…[9,11,12] Recent studies report the development of enhanced contact lens devices. [7][8][9][10][12][13][14][15][16][17] However, most of them rely on processes that are not scalable. Lab-made microfluidic contact lenses in the literature are primarily based on replica molding of hydrogels into curved surfaces.…”

Section: Introductionmentioning

confidence: 99%

Lab‐on‐a‐Contact Lens Platforms Fabricated by Multi‐Axis Femtosecond Laser Ablation

Moreddu

Nasrollahi

Kassanos

et al. 2021

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Contact lens sensing platforms have drawn interest in the last decade for the possibility of providing a sterile, fully integrated ocular screening technology. However, designing scalable and rapid contact lens processing methods while keeping a high resolution is still an unsolved challenge. In this article, femtosecond laser writing is employed as a rapid and precise procedure to engrave microfluidic networks into commercial contact lenses. Functional microfluidic components such as flow valves, resistors, multi‐inlet geometries, and splitters are produced using a bespoke seven‐axis femtosecond laser system, yielding a resolution of 80 µm. The ablation process and the tear flow within microfluidic structures is evaluated both experimentally and computationally using finite element modeling. Flow velocity drops of the 8.3%, 20.8%, and 29% were observed in valves with enlargements of the 100%, 200%, and 300%, respectively. Resistors yielded flow rate drops of 20.8%, 33%, and 50% in the small, medium, and large configurations, respectively. Two applications were introduced, namely a tear volume sensor and a tear uric acid sensor (sensitivity 16 mg L−1), which are both painless alternatives to current methods and provide reduced contamination risks of tear samples.

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Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing

Abstract: Microchannels created in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogels have the potential to prevent dry-eye disease by facilitating tear exchange. Biosensors are further demonstrated for wearable biosensing applications.

Cited by 38 publications

References 31 publications

Hydrogels and Their Role in Biosensing Applications

Hydrogels and Their Role in Biosensing Applications

3D Printing in Eye Care

Lab‐on‐a‐Contact Lens Platforms Fabricated by Multi‐Axis Femtosecond Laser Ablation

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