Microencapsulation of Traditional Chinese Herbs—PentaHerbs extracts and potential application in healthcare textiles

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

“…However, there was a great loss of major active ingredients of the herbal medicine in the fabrication of the microcapsule, resulting in both low drug loading and encapsulation efficiency. Clinical trials demonstrated that the medical textile therapy failed to treat AD patients [90,91]. In clinical practice, Hui and coworkers recently developed a textile therapy functionalized with TCM for AD treatment using microencapsulation technology [90,91].…”

“…Clinical trials demonstrated that the medical textile therapy failed to treat AD patients [90,91]. In clinical practice, Hui and coworkers recently developed a textile therapy functionalized with TCM for AD treatment using microencapsulation technology [90,91]. The fabrication strategy was an emulsion chemical crosslinking method (Figure 3A), by which the herbal medicines (PentaHerbs formula and cortex moutan) were successfully loaded into chitosan and sodium alginate composite microcapsules.…”

“…Huangbai Zicao Diyu cream Cortex phellodendri 50 g; Radix arnebiae 50 g; Radix sanguisorbae 100 g [81] Huanglian Qingdai ointment Rhizoma coptidis 0.6 g; Indigo naturalis 0.3 g; Cortex phellodendri 0.3 g; Alum 0.3 g; Borneolum syntheticum; Urea cream 40 g [81] Xiao-Feng-San (XFS) Radix saposhnikovia 2.5 mg; Herba schizonepetae 2.5 mg; Radix angelicae sinensis 2.5 mg; Radix rehmanniae 2.5 mg; Radix sophorae flavescentis 2.5 mg; Rhizoma atractylodis 2.5 mg; Periostracum cicdae 2.5 mg; Linum usitatissimum 2.5 mg; Rhizoma anemarrhenae 2.5 mg; Gypsum fibrosum 2.5 mg; Caulis clematidis armandii 1.25 mg; Radix glycyrrhizae 1.25 mg; Fructus arctii 2.5 mg [81,82] TCHM capsules Flos lonicerae 2 g; Herba menthae 1 g; Cortex moutan 2 g; Rhizoma atractylodis 2 g; Cortex phellodendri 2 g [83,84] Byakkokaninjinto Gypsum fibrosum; Anemarrhenae rhizome; Glycyrrhizae radix; Ginseng radix; Oryzae fructus [85,86] Juzen-Taiho-to Astragali Radix; Cinnamomi Cortex, Rehmanniae Radix; Paeoniae Radix; Cnidii Rhizoma; Atractylodis Lanceae Rhizoma; Angelicae Radix; Ginseng Radix; Hoelen; Glycyrrhizae Radix [85,87] Keishibukuryogan Cinnamomi cortex; Paeoniae Radix; Moutan cortex; Persicae semen; Hoelen [85,88] Gami-Cheongyeul-Sodok-Eum Angelica gigas; Astragalus membranaceus; Atractylodes japonica; Coptis japonica; Forsythia virdissima; Glycyrrhiza uralensis; Lonicera japonica; Portulaca oleracea; Scutellaria baicalensis [89] In clinical practice, Hui and coworkers recently developed a textile therapy functionalized with TCM for AD treatment using microencapsulation technology [90,91]. The fabrication strategy was an emulsion chemical crosslinking method (Figure 3A), by which the herbal medicines (PentaHerbs formula and cortex moutan) were successfully loaded into chitosan and sodium alginate composite microcapsules.…”

Microencapsulation of bioactives for food applications

“…104 For the complex coacervation, chitosan is the preferable wall material, and alginate is the most commonly used polymer in all the mentioned studies. 92,93,[105][106][107] Chitosan has low toxicity, antimicrobial activity, and biocompatibility, but it is mainly muco-adherence that allows transmucosal absorption and better release of the bioactives. 107 In simple coacervation the initially soluble polymer is precipitated by changing the pH or temperature.…”

“…A successful microencapsulated system not only has to protect the bioactive compound ensuring its bioavailability, but also needs to guarantee the intended release behaviour (temporal and target oriented). In vitro release studies can be performed by simulating the gastrointestinal environment using pH buffers mimicking the conditions of digestion, 106,156 or using in vitro gastrointestinal models comprising enzymes and pH buffers. 110,133,143,150 Tavano et al 156 showed, by in vitro release studies, that curcumin and quercetin when microencapsulated in niosomes improved the solubility after gastrointestinal digestion.…”