Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

Pascoa, Henrique; Diniz, Danielle Guimarães Almeida; Florentino, Iziara Ferreira; Costa, Élson Alves; Bara, Maria Teresa Freitas

doi:10.1590/s1984-82502015000100013

Cited by 20 publications

(13 citation statements)

References 51 publications

(55 reference statements)

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“…Terpenoids from seeds of sucupira, especially vouacapan diterpenes, develop a main role as bioactive compounds of this plant [30, 31], being major constituents of the ambar coloured oleoresin obtained from its seeds. This oily material was subjected to some studies aiming to develop emulsions with submicrometer droplets [29, 32]. Considering the larvicidal potential of sucupira oleoresin and its terpenoids against Aedes aegypti [33, 34], a promising larvicidal nanoemulsion against this vector larvae was prepared using this raw material [25].…”

Section: Introductionmentioning

confidence: 99%

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

et al. 2017

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BackgroundPreparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. Pterodon emarginatus, popularly known as sucupira, has a promising bioactive oleoresin. However, to our knowledge, no previous studies were carried out to evaluate its potential against Culex quinquefasciatus, the main vector of the tropical neglected disease called lymphatic filariasis or elephantiasis. Thus, we aimed to investigate influence of different pairs of surfactants in nanoemulsion formation and investigate if a sucupira oleoresin-based nanoemulsion has promising larvicidal activity against this C. quinquefasciatus. We also evaluated morphological alteration, possible mechanism of insecticidal action and ecotoxicity of the nanoemulsion against a non-target organism.ResultsAmong the different pairs of surfactants that were tested, nanoemulsions obtained with polysorbate 80/sorbitan monooleate and polysorbate 80/sorbitan trioleate presented smallest mean droplet size just afterwards preparation, respectively 151.0 ± 2.252 and 160.7 ± 1.493 nm. They presented high negative zeta potential values, low polydispersity index (<0.300) and did not present great alteration in mean droplet size and polydispersity index after 1 day of preparation. Overall, nanoemulsion prepared with polysorbate 80/sorbitan monooleate was considered more stable and was chosen for biological assays. It presented low LC50 value against larvae (34.75; 7.31–51.86 mg/L) after 48 h of treatment and some morphological alteration was observed. The nanoemulsion did not inhibit acetylcholinesterase of C. quinquefasciatus larvae. It was not toxic to green algae Chlorella vulgaris at low concentration (25 mg/L).ConclusionsOur results suggest that optimal nanoemulsions may be prepared with different surfactants using a low cost and low energy simple method. Moreover, this prototype proved to be effective against C. quinquefasciatus, being considered an ecofriendly novel nanoproduct that can be useful in integrated control programs of vector control.

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Section: Introductionmentioning

confidence: 99%

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

et al. 2017

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“…Pascoa et al, have prepared microemulsions using Pterodon emarginatus oil. It was found that microemulsions containing 5–10% oil phase exerted an anti-inflammatory effect which was superior to the oil used as a single remedy [ 241 ].…”

Section: Microemulsions In a New Vision For An Optimized Acne Thermentioning

confidence: 99%

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

et al. 2020

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With a fascinating complexity, governed by multiple physiological processes, the skin is considered a mantle with protective functions which during lifetime are frequently impaired, triggering dermatologic disorders. As one of the most prevalent dermatologic conditions worldwide, characterized by a complex pathogenesis and a high recurrence, acne can affect the patient’s quality of life. Smart topical vehicles represent a good option in the treatment of a versatile skin condition. By surpassing the stratum corneum known for diffusional resistance, a superior topical bioavailability can be obtained at the affected place. In this direction, the literature study presents microemulsions as a part of a condensed group of modern formulations. Microemulsions are appreciated for their superior profile in matters of drug delivery, especially for challenging substances with hydrophilic or lipophilic structures. Formulated as transparent and thermodynamically stable systems, using simplified methods of preparation, microemulsions have a simple and clear appearance. Their unique structures can be explained as a function of the formulation parameters which were found to be the mainstay of a targeted therapy.

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“…• The major advantage of this kind of formulation is that it taken orally or parentally and their site of release can also be targeted [44].…”

Section: Microspherementioning

confidence: 99%

Medicinal Plants Having Antifungal Properties

Mishra¹,

Kaur²,

Sahu³

et al. 2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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In the past few decades, a worldwide increase in the incidence of fungal infections has been observed as well as rise in the resistance of some species of fungi to different fungicidal used in medicinal practice. Besides, fungi are the one of the most neglected pathogens as demonstrated by the fact that the amphotericin B and other sold treatments are still used as gold standard as antifungal therapy. The majority of used antifungal treatments have various drawbacks in terms of toxicity, efficacy as well as cost and their frequent use has also led to the emergence of resistant strains. Hence, there is a great demand for developing an antifungal belonging to a wide range of structural classes, selectively acting on new targets with least side effects. Natural products, either as pure phytocompounds or as standardized plant extracts, provide unlimited opportunities for new drug lads because of their having normally matchless chemical diversity. Present chapter focused on the work done in the field of antifungal activities of various plant components and novel approaches which will be the future prospective for the new drug discoveries and providing better antifungal therapy.

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Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

Cited by 20 publications

References 51 publications

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

Medicinal Plants Having Antifungal Properties

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