Microemulsion-based hydrogel formulation of ibuprofen for topical delivery

Chen, Huabing; Chang, Xueling; Du, Danrong; Li, Jin; Xu, Huibi; Yang, Xiangliang

doi:10.1016/j.ijpharm.2006.02.015

Cited by 235 publications

(134 citation statements)

References 20 publications

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“…The results do not follow the general trend, which could be owing to better interaction of small droplets of oil with SC which was achieved at a high amount of surfactant mixture. The small droplets settled down to close contact with skin and a large amount of drugs from oil in NE could be penetrated across skin [44]. In addition, previous data suggests that permeation rate decreases at a very high concentration of surfactant mixture (more that 50%), and high oil with high surfactant content in NE may synergistically affect the skin permeation rate [23,48].…”

Section: Ex Vivo Skin Permeation Studiesmentioning

confidence: 92%

“…Similar findings were reported by Yuan and associates [23], that the increase in IPM as oil from 5% to 15% w/w, globules size of meloxicam-loaded microemulsion was correspondingly increased. The significantly increased globules size with increasing oil concentration could be attributed to expansion of oil droplets of NE by further addition of the oil [43,44]. In contrast, mean globules size of NEs decreases on increasing S/CoS concentration at fixed oil content (10% w/w) ( Table 4), which might be explained that increase in S/CoS concentration reduce the interfacial tension of oil and water.…”

Section: Characterisation Of Nanoemulsionsmentioning

confidence: 97%

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Enhanced transdermal delivery of carvedilol using nanoemulsion as a vehicle

Rizwan¹,

Aqil²,

Azeem³

et al. 2010

Journal of Experimental Nanoscience

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The aim of the present study was to develop nanoemulsion as a possible vehicle for enhanced transdermal penetration of carvedilol (CVD). For screening of nanoemulsion components, solubility of CVD in oils, surfactants and co-surfactants was determined. Various surfactants and co-surfactants were screened for their ability to nanoemulsify the selected oily phases. The obtained results indicated that Acconon CC6Õ had shown good nanoemulsification efficiency (minimum surfactant required S min ¼ 46.52% w/w) among the selected surfactants and further improved in presence of Õ (S min ¼ 37.11% w/w). The ranges of nanoemulsion existence were delineated through the construction of the pseudo-ternary phase diagram at different ratio of surfactant mixture (S/ CoS), and various nanoemulsions were selected from phase diagram of S/CoS ratio 1 : 1. The effect of content of oil and S/CoS (1 : 1) on the skin permeation of CVD was evaluated through an excised wistar rat skin using Franz diffusion cell. All the nanoemulsions showed a high skin permeation rate (92.251-161.53 mg/ cm 2 /h), good enhancement ratio (3.5-6.2) and high permeability coefficient in comparison to control groups. The optimised nanoemulsion formulation with the highest skin permeation rate (161.53 mg/cm 2 /h) consisted of 0.25% w/w CVD, 12.5% w/w Miglyol 810 Õ , 50% w/w Acconon CC6 Õ /CO-20 Õ (1 : 1) and water. The above formulation had the smallest mean globules size (9.28 nm). The superior transdermal flux of CVD may be due to nanorange size of oil globules that lead to intimate contact with the skin layer. These studies suggest that the nanoemulsion system is a promising vehicle for the transdermal delivery of CVD.

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Section: Ex Vivo Skin Permeation Studiesmentioning

confidence: 92%

Section: Characterisation Of Nanoemulsionsmentioning

confidence: 97%

Enhanced transdermal delivery of carvedilol using nanoemulsion as a vehicle

Rizwan¹,

Aqil²,

Azeem³

et al. 2010

Journal of Experimental Nanoscience

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“…Since celecoxib is a hydrophobic drug; hence, our target was to prepare water in oil nanoemulsion. From the ternary plot, all the possible regions of nanoemulsion formation were estimated [9,17]. Following tables represent the surfactants, co-surfactant (S mix ): Oil:water titration values, which represented in pseudo-ternary plots.…”

Section: Construction Of Pseudo-ternary Plotmentioning

confidence: 99%

“…Nanoemulgel which is otherwise known as nanoemulsion-based hydrogel, by which we have to make some effort to improve its permeability and diffusibility. The main advantages of the nanoemulgel formulation are due to the presence of dual nature; means hydrophilic and hydrophobic bases which can deeply penetrate within the skin [9][10][11]. Moreover, it also improves nanoemulsion stability by declining the surface and interfacial tension and also increases the viscosity of the aqueous phase for proper drug administration.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Celecoxib Nanoemulgel

Bhattacharya

Prajapati

2017

Asian J Pharm Clin Res

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Objective: The main objective of this experiment was to prepare and optimized celecoxib nanoemulgel. This formulation can be used for acute rheumatoid arthritis patients. Methods:Celecoxib is a poorly water soluble drug. We prepared celecoxib nanoemulgel to improve intrinsic solubility of celecoxib and enhance deeper permeation throughout the skin. After several screening, the combination of acetonitrile, triacetin, campul 908P was considered for oil phase; acconon MC8-2EP as surfactant, and capmul MCM C-10 as a co-surfactant accordingly. As per Box-Behnken surface design model, optimization was done for all the 13 formulations.Results: Based on pseudo ternary plot, it was found that 4:1 S mix ratio was optimum and possessed maximum drug solubility. Further, screening shown, 0.25-0.75% carbopol-940 can be a stable candidate for hydrogel preparation. Prepared nanoemulsions and hydrogels were admixed to prepare nanoemulgel. Based on overlay plot, EG14* formulation was consider as optimum one, and various evaluation parameters were performed along with other formulations. Using Franz diffusion cell, in-vitro diffusion studies was performed. Almost all the formulations produces good qualitative drug release profile. The EG14* shown 95.50% drug release after 12 th hrs with standard Higuchi plot (R 2 value 0.9989). The optimum viscosity was found to be 521±0.81 mPas at 100 rpm. The appearance of the formulations was milky, yellowish white with expectable pH ranged from 5.8 to 6.7. The optimized formulation has good spreadability coefficient, good ex-vivo diffusion enhancement factor (3.03) as compare to marketed gel. Mostly, our formulations have less skin irritation and higher anti-inflammatory activity (92.56% of inhibition of paw edema for EG14*). Conclusion:From the thermodynamic studies, it was confirmed that EG14* maintained excellent stability profile in various heating-cooling cycle, centrifugation, and freeze-thaw cycle condition. Hence, it can be conclude that, our formulation, can be consider for pilot scale up.

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“…The increase of viscosity was due to the addition of Carbomer 940, which made the preparation more suitable for topical administration (Chen et al, 2006).…”

Section: Characterization Of Optimized Mesmentioning

confidence: 99%

Preparation and evaluation ofdl-praeruptorin A microemulsion based hydrogel for dermal delivery

Zhang

Hong

et al. 2014

Drug Delivery

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(2015) Preparation and evaluation of dl-praeruptorin A microemulsion based hydrogel for dermal delivery, Drug Delivery, 22:6, 757-764, DOI: 10.3109/10717544.2014 AbstractThe purpose of the present investigation was to develop and optimize the microemulsion (ME) as a transdermal system for Pd-Ia, a poor water soluble and low bioavailable drug. The pseudoternary phase diagrams were constructed for various ME formulations including oleic acid as the oil phase, Cremophor RH40 as the surfactant, ethanol as the cosurfactant, and water. The maximum cumulative amount permeated through rat abdominal skins per unit area in 32 h (Q 32 ), and the maximum flux were evaluated using the Franz diffusion cell in order to optimize the ME formulation. The results indicated that the optimized ME formulation was composed of oleic acid (5%, W/W), Cremophor RH40 ( , the maximum flux was 11.467 ± 0.500 mg cm À2 h À1. ME-gel was administered transdermally to rats. The mean plasma concentration of Pd-Ia following transdermal application of ME-gel could be maintained for 32 h at least and the half-life was evidently prolonged. It shows that the ME-gel could be a promising vehicle for dermal delivery of Pd-Ia.

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Microemulsion-based hydrogel formulation of ibuprofen for topical delivery

Cited by 235 publications

References 20 publications

Enhanced transdermal delivery of carvedilol using nanoemulsion as a vehicle

Enhanced transdermal delivery of carvedilol using nanoemulsion as a vehicle

Formulation and Optimization of Celecoxib Nanoemulgel

Preparation and evaluation ofdl-praeruptorin A microemulsion based hydrogel for dermal delivery

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