Microemulsion and micellar electrokinetic chromatography of steroids

Vomastová, L.; Mikšı́k, Ivan; Deyl, Z.

doi:10.1016/0378-4347(95)00502-1

Cited by 90 publications

(65 citation statements)

References 16 publications

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“…Other oils employed include medium chain alcohols, as they are not miscible with water, e.g., pentan-1-ol, hexan-1-ol and octan-1-ol [48]. Reports have shown that varying the oil concentration does not significantly affect MEEKC separations [10,12,44].…”

Section: Oil Phasementioning

confidence: 99%

Recent advances in the development and application of microemulsion EKC

et al. 2007

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Microemulsion EKC (MEEKC) is an electrodriven separation technique. Separations are typically achieved using oil-in-water microemulsions, which are composed of nanometre-sized oil droplets suspended in an aqueous buffer. The droplets are stabilised by a surfactant and a cosurfactant. The novel use of water-in-oil microemulsions has also been investigated. This review summarises the advances in the development of MEEKC separations and also the different areas of application including determination of log P values, pharmaceutical applications, chiral analysis, natural products and bioanalytical separations and the use of new methods such as multiplexed MEEKC and high speed MEEKC. Recent applications (2004-2006) are tabulated for each area with microemulsion composition details.

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Section: Oil Phasementioning

confidence: 99%

Recent advances in the development and application of microemulsion EKC

et al. 2007

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“…with SDS as the emulsion-forming solvents. 214 In some further studies aiming at comparing the selectivities of the two techniques among many other compounds some steroids were also included. [215][216][217] A good correlation was found between the retention characteristics of betamethasone and its esters and the respective log Pow values; 218 MEEKC is a good tool for the rapid estimation of log Pow values of a wide range of compounds, among them steroid hormone drugs.…”

Section: ·3 Microemulsion Electrokinetic Chromatography (Meekc)mentioning

confidence: 99%

Recent Advances in the Analysis of Steroid Hormones and Related Drugs

Gǒrög¹

2004

ANAL. SCI.

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“…Micellar parameters, aggregation number (n), hydrodynamic radius (R h ), phase ratio between the micelle and aqueous phases (Q), partial specific volumes (v) studied at different temperatures using dynamic light scattering [36,37] only with cetyl trimethylammonium chloride or sodium dodecyl sulfate [22,23]. These microemulsion systems have been used only as separation media [42,43]. Most investigations deal with the partition behaviour of chemical compounds (no drugs) with micelles using the MEEKC.…”

Section: Interactions Between Drugs and Microemulsionsmentioning

confidence: 99%

Use of affinity capillary electrophoresis for characterizing pharmaceutical colloidal vehicle systems thermodynamically

Neubert¹,

Mrestani²

2001

Biopharm & Drug Disp

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This review offers a detailed discussion of the interaction between pharmaceutical compounds and vehicles using the affinity capillary electrophoresis and the microemulsion electrokinetic chromatography. Partition coefficients of drugs were calculated between a micelle and an aqueous phases from the measurement of the migration time, provided the critical micelle concentration and the phase ratio are known. Thermodynamic quantities such as enthalpy and entropy changes of micellar solubilization were calculated from the temperature dependence of the partition coefficients. Partial specific volumes were measured using dynamic light scattering. The logarithm of the partition coefficients and the capacity factor in the micellar system were correlated with the logarithm of the n-octanol/water partition coefficients.

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Microemulsion and micellar electrokinetic chromatography of steroids

Cited by 90 publications

References 16 publications

Recent advances in the development and application of microemulsion EKC

Recent advances in the development and application of microemulsion EKC

Recent Advances in the Analysis of Steroid Hormones and Related Drugs

Use of affinity capillary electrophoresis for characterizing pharmaceutical colloidal vehicle systems thermodynamically

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