Microelectrode studies of unit discharges in the sensorimotor cortex

Cordeau, J. Pierre; Gybels, Jan; Jasper, Herbert H.; Poirier, Louis

doi:10.1212/wnl.10.6.591

Cited by 45 publications

(7 citation statements)

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“…Further evidence consistent with a role of the cerebellum in the initiation of movement has been provided by recent studies of the activity of ventralis lateralis neurons in relation to the tremor movements in both man (211)(212)(213) and monkey (214,215) . These recordings were stimulated by the discovery that the resting tremor of patients with Parkinsonism could be ameliorated by VL lesions (cL 216) .…”

Section: Initiation Of Movementmentioning

confidence: 55%

Motor Mechanisms of the CNS: Cerebrocerebellar Interrelations

Evarts¹,

Thach²

1969

Annu. Rev. Physiol.

342

122

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Section: Initiation Of Movementmentioning

confidence: 55%

Motor Mechanisms of the CNS: Cerebrocerebellar Interrelations

Evarts¹,

Thach²

1969

Annu. Rev. Physiol.

342

122

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“…The hypothesis of independent local oscillators predicts that tremor affecting different limbs is not likely to be coupled, whereas muscles within the same limb would be more likely to form a coupled assembly. Classic reports by Cordeau, 24 Alberts, 25 and Calne and Lader 26 indicate that this may be the case, but these investigators did not use statistical methods to validate their results.…”

Section: Discussionmentioning

confidence: 99%

Inter‐ and intralimb oscillator coupling in Parkinsonian tremor

et al. 2000

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“…PD is also associated with enhanced oscillations at 3-7 Hz and 7-30 Hz in the BGTCS, which have been observed in humans and in animal models of PD in the GPi and GPe (Filion and Tremblay, 1991;Levy et al, 2002;Nini et al, 1995;Raz et al, 2000), STN (Bergman et al, 1994;Levy et al, 2000;Wang et al, 2005), SNr (Wichmann et al, 1999), pallidal and cerebellar-receiving areas of the thalamus (Lamarre and Joffroy, 1979;Lenz et al, 1994;Magnin et al, 2000;Ohye et al, 1974Ohye et al, , 1989, striatal medium spiny neurons (Dejean et al, 2008) and tonically active interneurons (Raz et al, 2001), and sensory and motor cortices (Alberts et al, 1969;Cordeau et al, 1960;Lamarre and Joffroy, 1979;Timmermann et al, 2003;Volkmann et al, 1996). In the GPi of PD patients, ∼5 Hz oscillations were found to be more common than 15-20 Hz oscillations (Levy et al, 2001).…”

Section: Overview Of Experimental Findingsmentioning

confidence: 98%

Mean-field modeling of the basal ganglia-thalamocortical system. II

Albada

Gray

Drysdale

et al. 2009

Journal of Theoretical Biology

103

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Neuronal correlates of Parkinson's disease (PD) include a shift to lower frequencies in the electroencephalogram (EEG) and enhanced synchronized oscillations at 3-7 and 7-30 Hz in the basal ganglia, thalamus, and cortex. This study describes the dynamics of a recent physiologically-based mean-field model of the basal ganglia-thalamocortical system, and shows how it accounts for many key electrophysiological correlates of PD. Its detailed functional connectivity comprises partially segregated direct and indirect pathways through two populations of striatal neurons, a hyperdirect pathway involving a corticosubthalamic projection, thalamostriatal feedback, and local inhibition in striatum and external pallidum (GPe). In a companion paper, realistic steady-state firing rates were obtained for the healthy state, and after dopamine loss modeled by weaker direct and stronger indirect pathways, reduced intrapallidal inhibition, lower firing thresholds of the GPe and subthalamic nucleus (STN), a stronger projection from striatum to GPe, and weaker cortical interactions. Here it is shown that oscillations around 5 and 20 Hz can arise with a strong indirect pathway, which also causes increased synchronization throughout the basal ganglia. Furthermore, increased theta power with progressive nigrostriatal degeneration is correlated with reduced alpha power and peak frequency, in agreement with empirical results. Unlike the hyperdirect pathway, the indirect pathway sustains oscillations with phase relationships that coincide with those found experimentally. Alterations in the responses of basal ganglia to transient stimuli accord with experimental observations. Reduced cortical gains due to both nigrostriatal and mesocortical dopamine loss lead to slower changes in cortical activity and may be related to bradykinesia. Finally, increased EEG power found in some studies may be partly explained by a lower effective GPe firing threshold, reduced GPe-GPe inhibition, and/or weaker intracortical connections in parkinsonian patients. Strict separation of the direct and indirect pathways is not necessary to obtain these results.

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Microelectrode studies of unit discharges in the sensorimotor cortex

Cited by 45 publications

References 0 publications

Motor Mechanisms of the CNS: Cerebrocerebellar Interrelations

Motor Mechanisms of the CNS: Cerebrocerebellar Interrelations

Inter‐ and intralimb oscillator coupling in Parkinsonian tremor

Mean-field modeling of the basal ganglia-thalamocortical system. II

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