Microelectrode accuracy in deep brain stimulation surgery

Brahimaj, Bledi; Kochanski, Ryan B.; Sani, Sepehr

doi:10.1016/j.jocn.2018.01.020

Cited by 13 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The procedure provides electrical stimulation by burning the brain regions such as the subthalamic nucleus, the globus pallidus internus and the ventralis intermediate nucleus of the thalamus, using high frequency sound waves. It reduces the activity of abnormally increasing cells, or by increasing dopamine activity through deep electrodes placed in this region, for preventing Clinical Science clinical signs and symptoms (9,14,18,20). It does not cure the disease, but alleviates symptoms such as tremor, rigidity and bradykinesia, improves the quality of life of the patient, reduces or eliminates the amount of medication used, and provides independence in daily life activities (5,14,21).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Experiences of Patients with Deep Brain Stimulation in Parkinson’s Disease: Challenges, Expectations, and Accomplishments

İbrahimoğlu

Mersin

Akyol

2020

ama

View full text Add to dashboard Cite

Objectives. Deep brain stimulation (DBS) is a safe and effective alternative treatment of some movement disorders such as Parkinson's disease. Although DBS is an effective treatment for Parkinson's disease, because of the necessity of surgical intervention, follow-up and the effects on symptoms, this study was carried out to determine the challenges, expectations and accomplishments of patients with DBS in Parkinson’s disease.Materials and Methods. This qualitative study was carried out at the Neurosurgery Department of a research hospital in Turkey with seven patients who underwent DBS between 2008 and 2018. In the study, the challenges, expectations, and accomplishments of patients were investigated by using three focus group interviews in October 2018.Results. Among the participants, six patients were male, and one patient was female. The mean age of the patients was 56.85}16.48. Three main themes were revealed in the study. These were (1) Reborn; decrease in dependence, sense of accomplishment, enjoyment of life, (2) Prejudice; perceived as severely ill by others and (3) Fear; not being accustomed to the device, loss of device function.Conclusion. The results obtained from this study can be used in the process of adaptation to this process by discussing and evaluating the challenges, expectations and accomplishments of the Parkinson's patient in DBS with healthcare professionals and other patients.

show abstract

Section: Introductionmentioning

confidence: 99%

“…In the literature, it may be seen that studies have usually focused on clinical symptoms and procedures (18,20,(22)(23)(24)(25)(26). However, since each patient's emotions are different, their direct statements as first persons and explanations of their experiences can guide other patients and healthcare professionals.…”

Section: Introductionmentioning

confidence: 99%

The Experiences of Patients with Deep Brain Stimulation in Parkinson’s Disease: Challenges, Expectations, and Accomplishments

İbrahimoğlu

Mersin

Akyol

2020

ama

View full text Add to dashboard Cite

show abstract

“…Hence, identifying the position at which the electrode is placed to the most accurate extent possible is extremely important. During DBS surgery, drainage of cerebro-spinal fluid or air entering inside the cranium can displace the target as much as several millimeters from its theoretical coordinates [45,46]. Identification of a neural structure by its electrophysiological properties prevents errors from occurring due to this morphological change of the brain.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological Characterization of Thalamic Nuclei in Epileptic Anaesthetized Patients

et al. 2019

View full text Add to dashboard Cite

Deep brain stimulation (DBS) requires precise localization, which is especially difficult at the thalamus, and even more difficult in anesthetized patients. We aimed to characterize the neurophysiological properties of the ventral intermediate (V.im), ventral caudal (V.c), and centromedian parvo (Ce.pc) and the magnocellular (Ce.mc) thalamic nuclei. We obtained microelectrode recordings from five patients with refractory epilepsy under general anesthesia. Somatosensory evoked potentials recorded by microelectrodes were used to identify the V.c nucleus. Trajectories were reconstructed off-line to identify the nucleus recorded, and the amplitude of the action potential (AP) and the tonic (i.e., mean frequency, density, probability of interspike interval) and phasic (i.e., burst index, pause index, and pause ratio) properties of the pattern discharges were analyzed. The Mahalanobis metric was used to evaluate the similarity of the patterns. The mean AP amplitude was higher for the V.im nucleus (172.7 ± 7.6 µV) than for the other nuclei, and the mean frequency was lower for the Ce.pc nucleus (7.2 ± 0.8 Hz) and higher for the V.c nucleus (11.9 ± 0.8 Hz) than for the other nuclei. The phasic properties showed a bursting pattern for the V.c nucleus and a tonic pattern for the centromedian and V.im nuclei. The Mahalanobis distance was the shortest for the V.im/V.c and Ce.mp/Ce.pc pairs. Therefore, the different properties of the thalamic nuclei, even for patients under general anesthesia, can be used to positively define the recorded structure, improving the exactness of electrode placement in DBS.

show abstract

“…Other sources of targeting errors include the settings of all hardware components which are cumulative and radiographic and software errors related to MR and CT image resolution and fusion. These collective errors were studied by Brahimaj et al [46] who measured the final coordinates of a single MER tract at "target" with intraoperative CT and measured the radial distance error from the coordinates of the intended target location. They found a mean error of 1.23 mm from a total of 150 STN targets and a mean error of 1.10 mm from a total of 27 GPi targets.…”

Section: Subcortical Mapping Using Microelectrode Recording For Dbs Placementmentioning

confidence: 99%

Parkinson’s Disease: Deep Brain Stimulation

Crammond

Richardson

2020

Stereotactic and Functional Neurosurgery

View full text Add to dashboard Cite

Microelectrode accuracy in deep brain stimulation surgery

Cited by 13 publications

References 18 publications

The Experiences of Patients with Deep Brain Stimulation in Parkinson’s Disease: Challenges, Expectations, and Accomplishments

The Experiences of Patients with Deep Brain Stimulation in Parkinson’s Disease: Challenges, Expectations, and Accomplishments

Neurophysiological Characterization of Thalamic Nuclei in Epileptic Anaesthetized Patients

Parkinson’s Disease: Deep Brain Stimulation

Contact Info

Product

Resources

About