Microdosimetry and Its Applications

Rossi, Harald H.; Zaider, Marco

doi:10.1007/978-3-642-85184-1

Cited by 247 publications

(202 citation statements)

References 78 publications

(109 reference statements)

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“…1. The large size of tissue equivalent proportional counters ͑TEPC͒, classically used in microdosimetry measurements, 15 made it unsuitable for measurements in small increments close to the primary proton treatment field edge and within a phantom structure. The SOI microdosimeter, presented in detail in Ref.…”

Section: Experimental Methodsmentioning

confidence: 99%

Out‐of‐field dose equivalents delivered by proton therapy of prostate cancer

2007

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Measurements were performed to assess the dose equivalent outside a primary proton treatment field, using a silicon-on-insulator ͑SOI͒ microdosimeter. The SOI microdosimeter was placed on the surface of an anthropomorphic phantom and dose equivalents were determined as a function of lateral distance from a typical passively scattered and modulated prostate treatment field. Measurements were also completed within a polystyrene plate phantom as a function of depth for a distance of 5 cm from the field edge, as function of lateral distance from field edge at two different depths, and as a function of distance from the distal edge on the central beam axis. The dose equivalent at the surface of the anthropomorphic phantom decreases from 3.9 to 0.18 mSv/Gy when the lateral distance from the proton field edge increases from 2.5 to 60 cm. Measurements along the proton depth dose distribution at a constant distance of 5 cm from the primary field edge indicate a decrease in dose equivalent as a function of depth, with a 38% decrease relative to the surface dose at a depth of 5 cm in polystyrene. Measurements completed as a function of lateral distance from the primary field at two separate depths within polystyrene illustrate a convergence of the dose equivalent at approximately 20 cm from the primary field edge. Past the distal edge of the spreadout Bragg peak dose equivalents decrease exponentially for increasing distance, with an initial value of 1.6 mSv/Gy at 0.6 cm from the distal edge. Silicon microdosimetry measurements were also compared with published results obtained utilizing different measurement techniques. This study demonstrates the applicability of SOI microdosimetry in determining the dose equivalent outside proton treatment fields, and provides valuable information on the dose equivalent both at the surface and at depth experienced by prostate cancer patients treated with protons.

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Section: Experimental Methodsmentioning

confidence: 99%

Out‐of‐field dose equivalents delivered by proton therapy of prostate cancer

2007

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“…Microdosimetry, which measures the radiation effects on a micron or cellular level producing a lineal energy spectrum is suitable for the measurement of such radiation fields as it can consider radiation interactions from a wide range of particles and energies [7]. When this spectrum is correlated with a well established quality spectra [8] it is possible to determine the dose equivalent. The advantages of microdosimetry have led to the deployment of tissue equivalent proportional counters (TEPCs) [7] on near Earth space missions such as the International Space Station (ISS).…”

Section: Introductionmentioning

confidence: 99%

Solid State Microdosimetry With Heavy Ions for Space Applications

Wroe

Rosenfeld

Reinhard

et al. 2007

IEEE Trans. Nucl. Sci.

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Abstract-This work provides information pertaining to the performance of Silicon-On-Insulator (SOI) microdosimeters in heavy ion radiation fields. SOI microdosimeters have been previously tested in light ion radiation fields for both space and therapeutic applications, however their response has not been established in high energy, heavy ion radiation fields which are experienced in space. Irradiations were completed at the NASA Space Radiation Laboratory at BNL using 0.6 GeV/u Fe and 1.0 GeV/u Ti ions. Energy deposition and lineal energy spectra were obtained with this device at various depths within a Lucite phantom along the central axis of the beam. The response of which was compared with existing proportional counter data to assess the applicability of SOI microdosimeters to future deployments in space missions.

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“…Microdosimetry [5] and nanodosimetry [6,7] have been developed to quantify the properties of the physical part of track structure in terms of stochastic microscopic quantities related to the transfer of energy to cells in tissue and the ionisation in chromosomes or DNA. For instance, one such quantity in microdosimetry is the lineal energy, defined as the ratio of the energy imparted to a particular micrometric target and the mean chord length of a passing particle track within the target volume.…”

mentioning

confidence: 99%

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

Rabus

Hilgers

Sharpe

et al. 2014

EPJ Web of Conferences

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Abstract. Funded within the European Metrology Research Programme (EMRP) [1], the joint research project "Biologically weighted quantities in radiotherapy" (BioQuaRT) [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 μm), and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.

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Microdosimetry and Its Applications

Cited by 247 publications

References 78 publications

Out‐of‐field dose equivalents delivered by proton therapy of prostate cancer

Out‐of‐field dose equivalents delivered by proton therapy of prostate cancer

Solid State Microdosimetry With Heavy Ions for Space Applications

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

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