Microdosimetric investigation at the therapeutic proton beam facility of CATANA

Nardo, L. De; Moro, Davide; Colautti, P.; Conte, V.; Tornielli, G.; Cuttone, G.

doi:10.1093/rpd/nch111

Cited by 40 publications

(22 citation statements)

References 2 publications

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“…These results were roughly consistent with the calculated RBE distributions reported in several previous papers [6, 7, 27]. Matsuura et al [28] reported that the experimental RBE value of HSG tumor cells at the Bragg peak for the mono-energetic 235-MeV proton beam was 1.18 ± 0.07 times higher than that at the plateau region and nearly independent of the dose rate.…”

Section: Discussionsupporting

confidence: 91%

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Microdosimetric calculation of relative biological effectiveness for design of therapeutic proton beams

Kase

Yamashita

Matsufuji³

et al. 2012

Journal of Radiation Research

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The authors attempt to establish the relative biological effectiveness (RBE) calculation for designing therapeutic proton beams on the basis of microdosimetry. The tissue-equivalent proportional counter (TEPC) was used to measure microdosimetric lineal energy spectra for proton beams at various depths in a water phantom. An RBE-weighted absorbed dose is defined as an absorbed dose multiplied by an RBE for cell death of human salivary gland (HSG) tumor cells in this study. The RBE values were calculated by a modified microdosimetric kinetic model using the biological parameters for HSG tumor cells. The calculated RBE distributions showed a gradual increase to about 1cm short of a beam range and a steep increase around the beam range for both the mono-energetic and spread-out Bragg peak (SOBP) proton beams. The calculated RBE values were partially compared with a biological experiment in which the HSG tumor cells were irradiated by the SOBP beam except around the distal end. The RBE-weighted absorbed dose distribution for the SOBP beam was derived from the measured spectra for the mono-energetic beam by a mixing calculation, and it was confirmed that it agreed well with that directly derived from the microdosimetric spectra measured in the SOBP beam. The absorbed dose distributions to planarize the RBE-weighted absorbed dose were calculated in consideration of the RBE dependence on the prescribed absorbed dose and cellular radio-sensitivity. The results show that the microdosimetric measurement for the mono-energetic proton beam is also useful for designing RBE-weighted absorbed dose distributions for range-modulated proton beams.

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Section: Discussionsupporting

confidence: 91%

“…However, a systematical uncertainty in the water-equivalent depth of about ±1.5 mm was estimated in consideration of the spherical wall and placement accuracy of the TEPC in the water phantom. A miniature TEPC would be effective for measuring microdosimetric spectra around the beam range with higher resolution [27]. …”

Section: Discussionmentioning

confidence: 99%

Microdosimetric calculation of relative biological effectiveness for design of therapeutic proton beams

Kase

Yamashita

Matsufuji³

et al. 2012

Journal of Radiation Research

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“…10 Additionally, the group at INFN Legnaro laboratories has proposed the mini TEPC to avoid pile up and to assess the RBE of the radiation by linking the physical microdosimetric parameters with the corresponding biological response. The feasibility of the mini TEPC has previously been tested in a 62 MeV proton beam 17 and recently used for monenergistic 12 C ion beam at CNAO. 18 Studies using the TEPC for microdosimetric measurements for both in-field and out-of-field in low dose rate 12 C and 7 Li ion pencil beams have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

et al. 2017

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The SOI microdosimeter with its well-defined 3D SV has applicability in characterizing proton radiation fields and can measure relevant physical parameters to model the RBE with submillimeter spatial resolution. It has been shown that for a physical dose of 1.82 Gy at the BP, the derived RBE based on the MKM model increased from 1.14 to 1.6 in the BP and its distal part. Good agreement was observed between the experimental and simulation results, confirming the potential application of SOI microdosimeter with 3D SV for quality assurance in proton therapy.

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“…To validate the operation of the micro-calorimeters and, in the future, to investigate the assumption made in ionisation-based microdosimeters that there is a proportionality between ionisation and energy deposition, comparisons will be performed with a silicon-microtelescope [12,13] and a mini-TEPC [14] that both have been tested extensively in proton beams [15,16].…”

Section: Microdosimetrymentioning

confidence: 99%

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

Rabus

Hilgers

Sharpe

et al. 2014

EPJ Web of Conferences

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Abstract. Funded within the European Metrology Research Programme (EMRP) [1], the joint research project "Biologically weighted quantities in radiotherapy" (BioQuaRT) [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 μm), and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.

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Microdosimetric investigation at the therapeutic proton beam facility of CATANA

Cited by 40 publications

References 2 publications

Microdosimetric calculation of relative biological effectiveness for design of therapeutic proton beams

Microdosimetric calculation of relative biological effectiveness for design of therapeutic proton beams

Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

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