Microdialysis sampling of cytokines

Ao, Xiaoping; Stenken, Julie A.

doi:10.1016/j.ymeth.2005.11.012

Cited by 104 publications

(104 citation statements)

References 88 publications

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“…The group of Stenken has made important contributions to the area. Among other things, the group found that the membrane provides more of the resistance to transport for larger macromolecules, than the tissue movement, thus different from small molecules (91,92). A theoretical and in vitro investigation of transmembrane convection with diffusion was made by Bungay et al with the 100-kDa molecular weight cut-off membranes, as a modification of sampling large molecules (51).…”

Section: Development Of Microdialysis and Alternativesmentioning

confidence: 99%

Microdialysis as an Important Technique in Systems Pharmacology—a Historical and Methodological Review

Hammarlund‐Udenaes

2017

AAPS J

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Abstract.Microdialysis has contributed with very important knowledge to the understanding of target-specific concentrations and their relationship to pharmacodynamic effects from a systems pharmacology perspective, aiding in the global understanding of drug effects. This review focuses on the historical development of microdialysis as a method to quantify the pharmacologically very important unbound tissue concentrations and of recent findings relating to modeling microdialysis data to extrapolate from rodents to humans, understanding distribution of drugs in different tissues and disease conditions. Quantitative microdialysis developed very rapidly during the early 1990s. Method development was in focus in the early years including development of quantitative microdialysis, to be able to estimate true extracellular concentrations. Microdialysis has significantly contributed to the understanding of active transport at the blood-brain barrier and in other organs. Examples are presented where microdialysis together with modeling has increased the knowledge on tissue distribution between species, in overweight patients and in tumors, and in metabolite contribution to drug effects. More integrated metabolomic studies are still sparse within the microdialysis field, although a great potential for tissue and disease-specific measurements is evident.

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Section: Development Of Microdialysis and Alternativesmentioning

confidence: 99%

Microdialysis as an Important Technique in Systems Pharmacology—a Historical and Methodological Review

Hammarlund‐Udenaes

2017

AAPS J

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“…However, the remarkable specificity of enzyme-based amperometric biosensors can be seriously undermined by interference from electroactive species present in the target medium, compromising the selectivity of the device. This problem is particularly pronounced for biosensors implanted in biological tissues for realtime monitoring [9,10,13,14], because separation techniques cannot be exploited to eliminate the interference, as is the case for on-line microdialysis approaches to in-vivo monitoring [8,[15][16][17]. Despite this drawback, considerable efforts have been made over the past two decades to overcome issues of in-vivo biosensor sensitivity, selectivity and stability, mainly because of the significant benefits of biosensor monitoring: small probe size, minimizing tissue damage [18][19][20]; and high time resolution, allowing real-time correlation with animal behavior [8,10,13,21].…”

Section: Introductionmentioning

confidence: 99%

Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo

O’Neill

Rocchitta

McMahon

et al. 2008

TrAC Trends in Analytical Chemistry

118

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Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity and selectivity parameters, which allow development of the basic design in a systematic way in order to improve their performance and to diversify the analyte range of these novel probes of brain function. ª

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“…MD is well established as a clinical sampling tool for monitoring small hydrophilic molecules such as lactate, puruvate and glucose in neurointensive care settings (Hillered et al 2005;Helmy et al 2007). There is a growing interest in monitoring larger and more complicated molecules such as neuropeptides (Rosdahl et al 2000;Dahlin et al 2004;Schutte et al 2004), cytokines (Ao and Stenken 2006) and proteins (Kjellstrom et al 1999;Clough et al 2007;Dahlin et al 2010). Monitoring larger molecules requires ultra-filtration or microfiltration membranes with molecular weight cut off (MWCO) of 100 kDa or above.…”

Section: Introductionmentioning

confidence: 99%

Influence of surface modification and static pressure on microdialysis protein extraction efficiency

Chu

Undin

Lind

et al. 2015

Biomed Microdevices

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Influence of surface modification and static pressure on microdialysis protein extractionefficiency. Biomedical microdevices (Print)http://dx.doi.org/10.1007/s10544-015-0005-3Access to the published version may require subscription. N.B. When citing this work, cite the original published paper. ABSTRACTThere is growing interest in using microdialysis (MD) for monitoring larger and more complex molecules such as neuropeptides and proteins. This promotes the use of MD membranes with molecular weight cut off (MWCO) of 100 kDa or above. The hydrodynamic property of the membrane goes to ultrafiltration or beyond, making the MD catheters more sensitive to pressure.In the meantime, despite the large pore size, studies have shown that membrane biofouling still lead to unstable catheter performance. The objective is to study in vitro how 500 kDa dextran and Poloxamer 407 surface modification affect the fluid recovery (FR) and extraction efficiency (EE) of 100 kDa MWCO MD catheters. A pressure chamber was designed to facilitate the tests, using as MD sample a protein standard with similar concentrations as in human cerebral spinal fluid, comparing native and Poloxamer 407 modified MD catheters. The collected dialysate fractions were examined for FR and protein EE, employing Dot-it Spot-it Protein Assay for total protein EE and targeted mass spectrometry (MS) for EE of individual proteins and peptides. The FR results suggested that the surface modified catheters were less sensitive to the pressure and provide higher precision, and provided a FR closer to 100%. The surface modification did not show a significant effect on the protein EE. The average total protein EE of surface modified catheters was slightly higher than that of the native ones. The MS EE data of individual proteins showed a clear trend of complex response in EE with pressure.

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Microdialysis sampling of cytokines

Cited by 104 publications

References 88 publications

Microdialysis as an Important Technique in Systems Pharmacology—a Historical and Methodological Review

Microdialysis as an Important Technique in Systems Pharmacology—a Historical and Methodological Review

Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo

Influence of surface modification and static pressure on microdialysis protein extraction efficiency

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