Microdialysis Assessment of Fibrin Glue Containing Sodium Alginate for Local Delivery of Doxorubicin in Tumor-Bearing Rats.

Kitazawa, Hidenori; Sato, Hitoshi; Adachi, Isao; Masuko, Yoh; Horikoshi, Isamu

doi:10.1248/bpb.20.278

Cited by 38 publications

(20 citation statements)

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“…It is now recognized that upon their activation, platelet granules release over 30 cytokines, including platelet-derived growth factor (PDGF), transforming growth factor (TGF), vascular endothelial growth factor (VEGF), insulinlike growth factor (IGF), and epidermal growth factor (EGF), 1, 2 as well as active substances such as serotonin, catecholamines, von Willebrand factor, proaccelerin, osteonectin, and antimicrobial proteins [12]. [109]. Coentrapment of aprotinin did not restrict the in vitro release of hydrophilic mitomycin C, fluorouracil or tegafur from FG, but slowed down the release of hydrophobic etoposide, doxorubicin and enocitabine [110].…”

Section: Protection Against Proteolysismentioning

confidence: 99%

Fibrin matrices: The versatile therapeutic delivery systems

Ahmad

Fatima

Hoque

et al. 2015

International Journal of Biological Macromolecules

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Section: Protection Against Proteolysismentioning

confidence: 99%

Fibrin matrices: The versatile therapeutic delivery systems

Ahmad

Fatima

Hoque

et al. 2015

International Journal of Biological Macromolecules

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“…[32][33][34] Apart from the routine use of fibrin glue as a hemostatic and sealant agent, it has been used for site-specific delivery of a variety of drugs, including antibiotics and anticancer agents. [35][36][37][38][39] The possible mechanism of drug release from fibrin sealant was suggested to occur probably by way of simple diffusion, so drugs applied with fibrin glue were shown to retain for a longer period of time than directly instilling to body cavities. 39 Although the difference between elimination period is reported to be dependent on the fibrinolytic activity that is different among the tissues, practically fibrin sealant is accepted to be absorbed completely 5-7 days after the operation when applied subcutaneously.…”

Section: Discussionmentioning

confidence: 99%

“…30 -34 As well as that, mixing various drugs into fibrin glue for slow release was shown to be a simple and effective site-specific drug-delivery system. 30,[35][36][37][38][39] When combined with drugs, sustained release from the sealant occurs by simple diffusion as the fibrin sealant is absorbed.…”

mentioning

confidence: 99%

Improved Flap Viability With Site-Specific Delivery of Sildenafil Citrate Using Fibrin Glue

Ulusoy¹,

Uysal²,

Koçer³

et al. 2005

Annals of Plastic Surgery

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Sildenafil is a cyclic guanosine-specific phosphodiesterase type 5 (PD-5) inhibitor that is widely used for erectile dysfunction. Potent and competitive inhibition of PD-5 enhances levels of cyclic guanosine monophosphate (cGMP). Fibrin glue-apart from tissue fixation-has been used for slow release of drugs. In this study, local delivery of Sildenafil citrate with fibrin glue was accomplished to improve random flap survival. Fifty Wistar rats were randomized into 5 groups, and a standardized dorsal random-pattern skin flap was elevated in each rat. In Group I (n = 10), the base of the flap was divided, making it a "graft" control to study the graft effect. In Group II (n = 10), a thin Silastic sheet was used to separate the flap from the underlying vascular bed, and no pharmacologic treatment was given. In Group III (n = 10), only 0.5 mL of fibrin glue was applied to the flap donor site. In Group IV (n = 10), 2.5 mg of sildenafil citrate mixed in 0.5 mL of fibrin glue was applied to donor site of the flap, whereas 10 mg of sildenafil citrate mixed in 0.5 mL of fibrin glue was applied in Group V (n = 10). Area of flap survival was evaluated on postoperative seventh day. Total necrosis of all of the flaps was observed in "graft" control group (Group I). Sildenafil and fibrin glue groups (Group IV and V) resulted in a statistically significant decrease in flap necrosis compared with Groups II and III (P < 0.0001). A statistically significant difference could not be documented between Group II and Group III (P > 0.0001). The decrease in skin necrosis was statistically significant in Group V compared with Group IV (P < 0.0001). Histologic examination revealed significantly increased vascular density in Groups IV and V compared with Groups II and III (P < 0.0001), whereas a significant difference could not be documented between Groups IV and V (P > 0.0001) and between Groups II and III (P > 0.0001). In view of these results, topical sildenafil application seems to improve flap survival in random-pattern skin flaps in dose-dependent manner.

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“…Others found that using sodium alginate in combination with fibrin glue extended the release of doxorubicin from the depot. 20 Incorporating microspheres into the fibrin matrix offers yet another possibility for optimizing delivery.…”

Section: Discussionmentioning

confidence: 99%