Microdetermination of cadmium and lead in whole blood by flameless atomic absorption spectrometry using carbon-tube and carbon-cup as sample cell and comparison with flame studies

Fd, Posma; Balke, J.; Rf, Herber; Ej, Stulk

doi:10.1021/ac60356a053

Cited by 29 publications

(3 citation statements)

References 19 publications

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“…This approach constitutes a wet ashing procedure and probably destroys the majority of the organic matrix, thereby converting the former "complex biological matrix" to a simpler system consisting of short chain hydrocarbons and dissolved salts. A similar effect appears to have been realized by Posma et al (23) and Garnys and Smythe (10) by adding concentrated acid directly to the sample within the atomizer. The utilization of HN03 oxidation of the sample may offer the unique advantage of allowing the use of aqueous standards for calibration.…”

Section: Resultssupporting

confidence: 64%

“…Nitric Acid. A large number of studies involving the determination of lead and other metals in blood and plasma used HN03 as an additive (2,6,10,12,(21)(22)(23)(24)(25). For discussion purposes an arbitrary division between dilute (<5%) and concentrated (>5%) acid concentrations will be made.…”

Section: Resultsmentioning

confidence: 99%

“…The addition of high concentration of HN03 to blood in a sample pretreatment step has been used by several workers (2, 10, 22,23,25). This approach constitutes a wet ashing procedure and probably destroys the majority of the organic matrix, thereby converting the former "complex biological matrix" to a simpler system consisting of short chain hydrocarbons and dissolved salts.…”

Section: Resultsmentioning

confidence: 99%

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Oxygen ashing and matrix modifiers in graphite furnace atomic absorption spectrometric determination of lead in whole blood

Eaton¹,

Holcombe²

1983

Anal. Chem.

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An evaluation of the chemical and/or physical involvement of a number of matrix modifiers and procedures Is presented for the determination of Pb In blood by graphite furnace atomic absorption. In particular, the roles of HN03, NH4H2P04, 02 ashing, and surfactants (such as Triton-X 100) have been studied. Appearance time shifts and changes In peak shape are also presented. A rapid method for the determination of Pb In human whole blood by graphite furnace atomic absorption spectrometry is also described. Sample preparation involves dilution of whole red cells 1:4 with 1% Trlton-X 100 solution, followed by an air ash. Oxygen ashing was used at 900 °C without any loss of Pb, no reduction In furnace lifetime, and negligible background scatter.

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Oxygen ashing and matrix modifiers in graphite furnace atomic absorption spectrometric determination of lead in whole blood

Eaton¹,

Holcombe²

1983

Anal. Chem.

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Cadmium Determination in Human Whole Blood by Electrothermal Atomic Absorption Spectrometry with Magnesium Chloride and Sodium Hydroxide as a Combined Chemical Modifier

Hsieh¹,

Yang

Lin³

1996

J Chinese Chemical Soc

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In this work, we propose a method to determine trace amounts of Cd in human whole blood samples by electrothermal atomic absorption spectrometry (ETAAS) with the combined chemical modifier including magnesium chloride and sodium hydroxide. Prior to the ETAAS analysis, dissolution of the blood samples is accomplished using a HNO3‐HClO4double closed‐vessel microwave digestion technique followed by drying of the dissolved blood samples by means of an infrared lamp. In using this approach, a MgCl2 chemical modifier is added to the digested samples, then they are injected into the graphite furnace for detecting the Cd level via atomic absorption spectrometer. Besides we used a NaOH chemical modifier, which removed the matrix major elements through prior ashing at 1200 ° C for 30 s, and the Cd is subsequently volatilized at 2200 °C and determined by AAS. However, the proposed method can be employed to determine the of Cd level in whole blood samples by the calibration technique and the standard‐additions method. Its validity is confirmed with two certified reference whole blood materials (Seronorm Trace Elements Whole Blood Batch no. 205052 and Batch no. 203056). By using 10 μL injections, a detection limit of 0.052 ng mL−1 is achieved.

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Atomabsorptionsspektrometrie und Atomfluoreszenzspektrometrie

Koch¹,

Fresenius

1985

Analytische Chemie Des Mangans

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Microdetermination of cadmium and lead in whole blood by flameless atomic absorption spectrometry using carbon-tube and carbon-cup as sample cell and comparison with flame studies

Cited by 29 publications

References 19 publications

Oxygen ashing and matrix modifiers in graphite furnace atomic absorption spectrometric determination of lead in whole blood

Oxygen ashing and matrix modifiers in graphite furnace atomic absorption spectrometric determination of lead in whole blood

Cadmium Determination in Human Whole Blood by Electrothermal Atomic Absorption Spectrometry with Magnesium Chloride and Sodium Hydroxide as a Combined Chemical Modifier

Atomabsorptionsspektrometrie und Atomfluoreszenzspektrometrie

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