Microcystic adnexal carcinoma of the face treated with radiation therapy: A case report and review of the literature

Pugh, Thomas J.; Lee, Nancy Y.; Pacheco, Theresa; Raben, David

doi:10.1002/hed.21690

Cited by 28 publications

(33 citation statements)

References 67 publications

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“…2, 13 Surgical extirpation with or without regional lymph node dissection followed by adjuvant radiotherapy in select cases is often performed, although definitive therapy with RT in lieu of an operation has been reported. 14, 15 Locoregional recurrence has been reported up to 60% after surgical excision alone. 16-18 …”

Section: Introductionmentioning

confidence: 99%

Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck

Wang

Handorf

Wu³

et al. 2017

American Journal of Clinical Oncology

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OBJECTIVES Skin adnexal carcinoma (SAC) is a rare cutaneous malignancy that arises from sebaceous and sweat glands. These carcinomas are believed to behave more aggressively than cutaneous squamous cell carcinomas (SCC) with a propensity for local recurrence. The role of adjuvant radiotherapy in SAC is undefined. METHODS We retrospectively reviewed all cases of head and neck SAC treated with surgery and adjuvant radiation from 2000-2012 at a single institution. RESULTS Nine cases were identified. Median age was 67 (range 52-88). The histologies were: adnexal carcinoma (n=1), adnexal carcinoma with sebaceous differentiation (n=1), adnexal carcinoma with squamous differentiation (n=1), skin appendage carcinoma (n=1), sclerosing sweat duct carcinoma (n=1), mucinous carcinoma (n=1), ductal eccrine adenocarcinoma (n=1), porocarcinoma (n=1), and trichilemmal carcinoma (n=1). All tumors were reviewed by a dermatopathologist to confirm the SAC diagnosis. All patients had surgery. Indications for adjuvant radiation included involved lymph nodes (n=4), perineural invasion (n=2), nodal extracapsular extension (n=2), positive margin (n=1), high-grade histology (n=6), multi-focal disease (n=2), and/or recurrent disease (n=5). Radiation was delivered to the primary site alone (n=3), to the draining lymphatics alone (n=2), or to both (n=4). One patient received concurrent cisplatin. Median dose to the primary site was 60Gy and to the neck was 50Gy. Median follow-up was 4.0 years (0.6-11.4 years). Locoregional control was 100%. Five-year progression free survival was 89%. There was one acute grade 3 toxicity and no ≥grade 2 late toxicities were recorded. CONCLUSIONS Surgery and adjuvant radiation for high-risk SAC offers excellent locoregional control with acceptable toxicity.

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Section: Introductionmentioning

confidence: 99%

Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck

Wang

Handorf

Wu³

et al. 2017

American Journal of Clinical Oncology

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“…The time to second recurrence in studied cases was much shorter and ranged from 3-24 months (9,14,15) . No cases of anaplastic transformation were appreciated at the time of recurrence (16) . Re-irradiation was attempted in two cases to avoid extensive excision on previously radiated tissue using very small fields (10, 12) .…”

Section: Resultsmentioning

confidence: 98%

Treatments for microcystic adnexal carcinoma – A review

Chaudhari¹,

Mortazie

Blattner

et al. 2015

Journal of Dermatological Treatment

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“…36,41 Postoperative radiotherapy has been found to improve disease control if operation is not successful. 42 It can also be used alone if an operation is likely to result in a poor cosmetic outcome. 42…”

Section: Microcystic Adnexal Carcinomamentioning

confidence: 99%

Malignant cutaneous adnexal tumours of the head and neck: an update on management

Green

Godden

Brennan

2015

British Journal of Oral and Maxillofacial Surgery

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Microcystic adnexal carcinoma of the face treated with radiation therapy: A case report and review of the literature

Abstract: PORT may improve local control in patients with microcystic adnexal carcinoma, and its use should be considered in patients with high-risk features for local recurrence. RT as monotherapy should be considered when poor cosmetic outcome can be anticipated via standard surgical treatments.

Cited by 28 publications

References 67 publications

Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck

Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck

Treatments for microcystic adnexal carcinoma – A review

Malignant cutaneous adnexal tumours of the head and neck: an update on management

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