Treatments for microcystic adnexal carcinoma – A review

Chaudhari, Soham; Mortazie, Michael B.; Blattner, Collin M.; Garelik, Jessica; Wolff, Marisa; Daulat, Jaldeep; Chaudhari, Prakash J.

doi:10.3109/09546634.2015.1089351

Cited by 25 publications

(32 citation statements)

References 49 publications

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“…It often presents as an indolent, non-ulcerated, smooth-surfaced, flesh-colored to yellowish asymptomatic nodule, papule, plaque, or cystic lesion with indistinct margins with a predilection for the head and neck, predominantly arising in the central face. 1,4,[11][12][13][14][15][16][17][18] It is paramount to include MAC as a differential diagnosis among the other head and neck lesions to enable early diagnosis and treatment to reduce morbidity and mortality. Deep incisional or excisional biopsy for histopathology is the gold standard for initial diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“… 1 – 26 It is characterized as a malignant, aggressive, and locally invasive tumor with a high recurrence rate. 2 – 4 , 8 , 9 , 11 – 17 , 19 MAC typically does not metastasize; however, there are reports of local and distant progression of the disease. 1 , 13 , 15 Although recognized as a distinct clinicopathologic entity, 3 MAC has proven to be diagnostically challenging as it can mimic other similar neoplasms.…”

Section: Introductionmentioning

confidence: 99%

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An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

Hinther

Henni

Asiniwasis

2020

SAGE Open Medical Case Reports

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Microcystic adnexal carcinoma is a rare cutaneous neoplasm believed to arise from pluripotent keratinocytes capable of adnexal differentiation. Due to its insidious growth and appearance, diagnosis is often delayed. A deep incisional or excisional biopsy for histopathology is the gold standard for diagnosis. Different treatment modalities have been described in the literature, including the Mohs micrographic surgery, standard excision, radiation, chemotherapy, and observation. Currently, Mohs remains the treatment of choice. We present a unique case of a 12-month history of an extensive progressive centrofacial cutaneous induration diagnosed as microcystic adnexal carcinoma in an 83-year-old female. Due to the extensive nature of the tumor, she received radiation therapy and continues to receive ongoing assessment with no evidence of clinical recurrence at 2-year post-treatment including negative scouting biopsies. To date, there is no consensus on the optimal treatment for microcystic adnexal carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

Hinther

Henni

Asiniwasis

2020

SAGE Open Medical Case Reports

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“…Local recurrence rates with wide local excision have been reported as high as 40% to 60%. 12 Pathologic “skip areas” 13 , 14 perineural invasion, 12 , 15 and the misinterpretation of atypical epithelioid structures as normal 16 are thought to contribute to this observance. Most SSDC recurrences occur within 2 years after treatment, 4 , 16 whereas others happen decades later.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing sweat duct carcinoma of the lower extremity treated with Mohs micrographic surgery

Harvey¹,

Long³

et al. 2016

JAAD Case Reports

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“…Incomplete incisions have been associated with high recurrence. Since MAC is a low-grade malignant gland cancer with low metastatic capacity, complete incisions are associated with much lower recurrence [17]. We followed up with this case for 14 months after the surgery, and no recurrence was observed.…”

Section: Managementsmentioning

confidence: 92%

Microcystic adnexal carcinoma: report of rare cases

et al. 2020

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Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive malignant neoplasm that derives from cutaneous eccrine/apocrine glands. MAC is classified as an eccrine/apocrine gland tumor and usually occurs in the skin. Here, we characterized and compared two cases of MAC. One is extremely rare in terms of its occurrence in the tongue. The other occurred in the lip, which is common. Histories of disease, diagnosis, and differentials were reviewed by the attending physicians. Hematoxylin and Eosin (HE) slides were evaluated by an experienced pathologist. Immunological markers for malignant eccrine/apocrine gland tumors were used to characterize the tumor’s nature. The examined markers included EMA, CK5/6, CK8/18, CK7, CK20, p63, S-100, Calponin, CD10, MYB, Bcl-2, Her-2, CD34, SMA, p53, CD43, CD117, and Ki-67. Both patients were males, presented with painless lumps in the lower lip and in the tongue, respectively. Both lumps were similar in terms of appearance, being whitish, and infiltrative with irregular borders. Both tumors also had similar histological features with nests of bland keratinocytes, cords, and ductal differentiation filled with Periodic acid–Schiff (PAS)-positive eosinophilic material. In both cases, circular or ovary tumor cells invaded into muscles and nerves. All tumor cells were CK5/6, CK8/18, EMA, and CK7 positive. Particularly, keratinocytes were p63 positive, and paraductal cells were p63, S-100, and SMA positive. Therefore, the rare case of MAC in the tongue appears to derive from the salivary gland.

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Treatments for microcystic adnexal carcinoma – A review

Abstract: Complete margin evaluation with MMS permits complete tumor removal with subsequently low recurrence rate.

Cited by 25 publications

References 49 publications

An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

An atypical presentation of extensive centrofacial microcystic adnexal carcinoma responding to radiation: A case report and review of the literature

Sclerosing sweat duct carcinoma of the lower extremity treated with Mohs micrographic surgery

Microcystic adnexal carcinoma: report of rare cases

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