Microcrystalline cellulose and its microstructure in pharmaceutical processing

Westermarck, Sari; Juppo, Anne; Kervinen, Lasse; Yliruusi, Jouko

doi:10.1016/s0939-6411(99)00051-x

Cited by 57 publications

(29 citation statements)

References 21 publications

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“…Tensile strength of compacts formed at a given compression pressure was inversely related to pellet porosity (12). The diminished porosity of MCC granules produced by wet granulation has also been reported by Westermack et al (13).…”

Section: Introductionsupporting

confidence: 70%

A Study on the Effect of Wet Granulation on Microcrystalline Cellulose Particle Structure and Performance

2006

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Section: Introductionsupporting

confidence: 70%

A Study on the Effect of Wet Granulation on Microcrystalline Cellulose Particle Structure and Performance

2006

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“…A common technique to study the pore structure of tablets is mercury intrusion porosimetry (e.g., Westermarck, 2000;Westermarck et al, 1999), a method that enables the determination of pore diameters in a wide size range of about 0.003 to 360 µm (Webb, 2001), i.e. from the nano-to the milli-scale.…”

Section: Introductionmentioning

confidence: 99%

The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction

Nordström

Persson

Lazorova

et al. 2013

International Journal of Pharmaceutics

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The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction. International Journal of Pharmaceutics AbstractThe effect of degree of compression on the evolution of tablet microstructure and bond probability during compression of granular solids has been studied.Microcrystalline cellulose pellets of low (about 11%) and of high (about 32%) porosity were used. Tablets were compacted at 100, 150 and 200 MPa applied pressures and the degree of compression and the tensile strength of the tablets determined. The tablets were subjected to mercury intrusion measurements and from the pore size distributions, a void diameter and the porosities of the voids and the intra-granular pores were calculated.The pore size distributions of the tablets had peaks associated with the voids and the intra-granular pores. The void and intra-granular porosities of the tablets were dependent on the original pellet porosity while the total tablet porosity was independent. The separation distance between pellets was generally lower for tablets formed from high porosity pellets and the void size related linearly to the degree of compression. Tensile strength of tablets was higher for tablets of high porosity pellets and a scaled tablet tensile strength related linearly to the degree of compression above a percolation threshold. In conclusion, the degree of compression controlled the separation distance and the probability of forming bonds between pellets in the tablet.3

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“…Because of its strong binding properties, it requires the addition of a disintegrant for an effective drug release, making formulations more costly. The compactibility of MCCI is also adversely affected when processed by high shear wet granulation since upon drying part of the water interacts with cellulose through hydrogen bonding and as a result, these hydrogen bonds are not available for further particle bonding [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Polymorphism on the Particle and Compaction Properties of Microcrystalline Cellulose

Rojas¹

2013

Cellulose - Medical, Pharmaceutical and Electronic Applications

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Microcrystalline cellulose and its microstructure in pharmaceutical processing

Cited by 57 publications

References 21 publications

A Study on the Effect of Wet Granulation on Microcrystalline Cellulose Particle Structure and Performance

A Study on the Effect of Wet Granulation on Microcrystalline Cellulose Particle Structure and Performance

The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction

Effect of Polymorphism on the Particle and Compaction Properties of Microcrystalline Cellulose

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