A Study on the Effect of Wet Granulation on Microcrystalline Cellulose Particle Structure and Performance

Abstract

The decrease in MCC compactibility after granulation is associated with the decrease in MCC primary particle porosity and in some cases with the formation of large dense granules as well. Under certain conditions, milling seems to counteract the effect of wet granulation on MCC compactibility.

Materials Science Tetrahedron—A Useful Tool for Pharmaceutical Research and Development

“…Variations in granule porosity can influence deformation behavior of granule 35, 77. Both granule mechanical properties and size can affect tableting performance of granules 36, 75, 78…”

“…For a given composition, structure of a granule by wet granulation process can be manipulated by processing parameters such as granulation fluid level, massing time, and drying temperature. The resulted changes in granule structure, such as granule porosity, affects the mechanical properties of a granule and thus performance during the subsequent tableting step 78, 91, 92. With the relationships understood, a granulation process can be designed to effectively produce granules of desired properties.…”

Characterisation of the interactive properties of microcrystalline cellulose–carboxymethyl cellulose hydrogels

“…The general compatibility of MCC changes during the granulation process. The reasons for such changes are not fully understood (Suzuki et al, 2001;Badawy et al, 2006). However, it is clear that microcrystalline cellulose has significantly different physical properties relative to those of the parent cellulose system.…”

Roles of Granule Size in Over-Granulation During High Shear Wet Granulation

“…Moreover, it was recently suggested that tabletability of HSWG granules does not depend on granule size. 15 At present, the relationship between granule size and tabletability of HSWG granules remains a subject of debate. Granule porosity was found to influence tabletability of MCC granules obtained by a low shear granulation process with the help of alcoholic solvents.…”

“…(1) It is commonly used in HSWG formulations, and (2) it has been widely used in previous investigation of the mechanism for over-granulation phenomenon. 15,16 MCC granules (100 g batch size) were made using a modified high shear blender (KitchenAid, 1.7 L bowl volume, two blades, 1750 rpm). Distilled water was sprayed into the powder bed through a nozzle at a rate of 25 g/min.…”