Microcontact printing of polydopamine on thermally expandable hydrogels for controlled cell adhesion and delivery of geometrically defined microtissues

Lee, Yu Bin; Kim, Se-Jeong; Kim, Eum Mi; Byun, Hayeon; Chang, Hyung-Kwan; Park, Jungyul; Choi, Yu Suk; Shin, Heungsoo

doi:10.1016/j.actbio.2017.07.040

Cited by 35 publications

(34 citation statements)

References 56 publications

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“…Particularly, hydrogels are challenging target substrates for μCP as they cannot withstand the pressure of stamps. To overcome this challenge, chemical modifications of hydrogels, such as freeze‐drying hydrogels or delivering pre‐printed materials on poly(vinyl alcohol) (PVA), have been extensively considered in the literature to improve both μCP and hydrogel compatibility 62 . Moreover, bioprinting of cell‐adhesive molecules, such as integrins that facilitate cell–cell and cell‐ECM adhesion onto biomaterial substrates, should also be considered 74 …”

Section: Microfabrication Techniquesmentioning

confidence: 99%

“…The development of 3D microtissues based on a thermally expandable hydrogel with microcontact-printed polydopamine patterns was successfully observed after subcutaneous implantation in a mouse model. 62 Compared with a simple monolayer of cells, as depicted in Figure 3B, the cell strips allowed a superior migratory activity and linear merging of translocated cells. Thus, organized microtissues proved their potential in developing structurally defined tissues by natural remodeling in vivo.…”

Section: Soft Lithographymentioning

confidence: 99%

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Advances in microfabrication technologies in tissue engineering and regenerative medicine

et al. 2022

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Background Tissue engineering provides various strategies to fabricate an appropriate microenvironment to support the repair and regeneration of lost or damaged tissues. In this matter, several technologies have been implemented to construct close‐to‐native three‐dimensional structures at numerous physiological scales, which are essential to confer the functional characteristics of living tissues. Methods In this article, we review a variety of microfabrication technologies that are currently utilized for several tissue engineering applications, such as soft lithography, microneedles, templated and self‐assembly of microstructures, microfluidics, fiber spinning, and bioprinting. Results These technologies have considerably helped us to precisely manipulate cells or cellular constructs for the fabrication of biomimetic tissues and organs. Although currently available tissues still lack some crucial functionalities, including vascular networks, innervation, and lymphatic system, microfabrication strategies are being proposed to overcome these issues. Moreover, the microfabrication techniques that have progressed to the preclinical stage are also discussed. Conclusions This article aims to highlight the advantages and drawbacks of each technique and areas of further research for a more comprehensive and evolving understanding of microfabrication techniques in terms of tissue engineering and regenerative medicine applications.

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Section: Microfabrication Techniquesmentioning

confidence: 99%

Section: Soft Lithographymentioning

confidence: 99%

Advances in microfabrication technologies in tissue engineering and regenerative medicine

et al. 2022

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“…However, further efforts are needed because the current biomimetic ECM is not yet close to the natural structure of ECM. Additionally, time- and cost-effective approaches are needed for the broad application. …”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Decoration of Material Surfaces with Complex Physicochemical Signals for Biointerface Applications

Shi

Liu

Zhang

et al. 2020

ACS Biomater. Sci. Eng.

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The surface properties of biomaterials are crucial at controlling biological interactions. Cells or tissues sense different stimuli from surfaces and respond accordingly. A number of studies have reported that fabricating complex stimuli-presenting surfaces is beneficial for mimicking and understanding the in vivo scenario where multi-physicochemical cues are present. Biological responses toward these surfaces could be either negative, such as immune responses, or positive, such as tissue regeneration. An ideal material surface should, therefore, be multifunctional, triggering the desired biological process and suppressing the unwanted side effects. The methods for material surface decoration can be very sophisticated, depending on the applications such as biosensors, medical devices, and/or implants. To date, decorating material surfaces with complex chemistries and topographies is still challenging, and methods are not straightforward. The majority of the methods require multiple steps and combinational approaches that include mask-based techniques, lithography, wet or dry etching, wet chemistry, or vapor-based coatings, among others. Although these methods have been established in the laboratory, easy-to-access and straightforward approaches need to be explored. This Review summarizes the state-of-the-art techniques for generating patterned multichemical and multitopographic signals on material surfaces, and the potential of having these surfaces in biointerface applications.

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“…This colourful digging toad occurs in the semi-arid grasslands and black soil plains of central inland New South Wales and the interior of southern Queensland, west of the Great Dividing Range in Australia. The use of bioadhesive or hydrogels as delivery systems for therapeutic cells, drugs or antibiotics is another innovative development in repair biology but has yet to be applied in meniscal repair procedures [124,125,126,127,128].…”

Section: Current Approaches In Meniscal Repairmentioning

confidence: 99%

The Importance of the Knee Joint Meniscal Fibrocartilages as Stabilizing Weight Bearing Structures Providing Global Protection to Human Knee-Joint Tissues

Melrose

2019

Cells

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The aim of this study was to review aspects of the pathobiology of the meniscus in health and disease and show how degeneration of the meniscus can contribute to deleterious changes in other knee joint components. The menisci, distinctive semilunar weight bearing fibrocartilages, provide knee joint stability, co-ordinating functional contributions from articular cartilage, ligaments/tendons, synovium, subchondral bone and infra-patellar fat pad during knee joint articulation. The meniscus contains metabolically active cell populations responsive to growth factors, chemokines and inflammatory cytokines such as interleukin-1 and tumour necrosis factor-alpha, resulting in the synthesis of matrix metalloproteases and A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats (ADAMTS)-4 and 5 which can degrade structural glycoproteins and proteoglycans leading to function-limiting changes in meniscal and other knee joint tissues. Such degradative changes are hall-marks of osteoarthritis (OA). No drugs are currently approved that change the natural course of OA and translate to long-term, clinically relevant benefits. For any pharmaceutical therapeutic intervention in OA to be effective, disease modifying drugs will have to be developed which actively modulate the many different cell types present in the knee to provide a global therapeutic. Many individual and combinatorial approaches are being developed to treat or replace degenerate menisci using 3D printing, bioscaffolds and hydrogel delivery systems for therapeutic drugs, growth factors and replacement progenitor cell populations recognising the central role the menisci play in knee joint health.

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Microcontact printing of polydopamine on thermally expandable hydrogels for controlled cell adhesion and delivery of geometrically defined microtissues

Cited by 35 publications

References 56 publications

Advances in microfabrication technologies in tissue engineering and regenerative medicine

Advances in microfabrication technologies in tissue engineering and regenerative medicine

Decoration of Material Surfaces with Complex Physicochemical Signals for Biointerface Applications

The Importance of the Knee Joint Meniscal Fibrocartilages as Stabilizing Weight Bearing Structures Providing Global Protection to Human Knee-Joint Tissues

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