Microcontact printing of novel co-polymers in combination with proteins for cell-biological applications

Csúcs, Gábor; Roger, Michel; Lussi, Jost W.; Textor, Marcus; Danuser, Gaudenz

doi:10.1016/s0142-9612(02)00568-9

Cited by 197 publications

(190 citation statements)

References 26 publications

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“…This is on account of the fact that polymeric materials generally tend to be cheaper than metals and ceramics and can be seen in many instances to be easier to machine and manipulate to adapt the polymer for use in specific environments, especially biological environments. To this end, micro-and nano-printing has been developed and applied to polymeric materials [116][117][118][119][120][121]. A typical surface resulting from micro-contact printing can be seen in Figure 6.…”

Section: Micro/nano Contact Printingmentioning

confidence: 99%

“…This is evidenced by Ruiz et al [116] and Dusseiller et al [120] who showed that neural cell growth and epithelial cell growth can be manipulated with this technique, respectively. This technique has been advanced further by using proteins in the micro/nano contact printing [117][118][119] which allows for a more bio-functionalized surface to be developed.…”

Section: Micro/nano Contact Printingmentioning

confidence: 99%

See 1 more Smart Citation

Surface Treatments to Modulate Bioadhesion: A Critical Review

Waugh¹,

Toccaceli²,

Gillett³

et al. 2016

rev adhes adhesives

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On account of the recent increase in importance of biological and microbiological adhesion in industries such as healthcare and food manufacturing many researchers are now turning to the study of materials, wettability and adhesion to develop the technology within these industries further. This is highly significant as the stem cell industry alone, for example, is currently worth £3.5 million in the United Kingdom (UK) alone. This paper reviews the current state-of-the-art techniques used for surface treatment with regards to modulating biological adhesion including laser surface treatment, plasma treatment, micro/nano printing and lithography, specifically highlighting areas of interest for further consideration by the scientific community. What is more, this review discusses the advantages and disadvantages of the current techniques enabling the assessment of the most attractive means for modulating biological adhesion, taking in to account cost effectiveness, complexity of equipment and capabilities for processing and analysis.

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Section: Micro/nano Contact Printingmentioning

confidence: 99%

Section: Micro/nano Contact Printingmentioning

confidence: 99%

Surface Treatments to Modulate Bioadhesion: A Critical Review

Waugh¹,

Toccaceli²,

Gillett³

et al. 2016

rev adhes adhesives

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show abstract

“…За счет капиллярных взаимодействий штамп переносит раствор на обрабатываемую поверхность. В настоящее время микроконтакт-ная печать может быть использована для переноса практически любого материала: металлов [19], полимеров [20], биоматериала [21], различных наноструктур [22,23].…”

Section: микроконтактная печатьunclassified

Methods of surface chemical patterning

Kuznetsov¹,

Puchnin²,

Grudtsov³

2016

NanoRus

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Рассмотрены масочные и безмасочные методы функционализации для формирования рисунков на поверхностях различных материалов. The mask and mask-free methods of functionalization for the surface patterning of different materials are considered. Функционализация поверхности -придание ей новых свойств путем частичного или пол-ного изменения состава функциональных химических групп. Различные методы модифи-кации активно используются в современной тех-нологии для управления смачиваемостью поверх-ности, повышения ее устойчивости к коррозии, обеспечения биосовместимости материа ла, изме-нения механических свойств. В нанотехнологиях, помимо модификаций свойств, методы функцио-нализации поверхности нашли широкое приме-нение в формировании микро-и нанорисунков и шаблонов на их основе [1].В соответствии с используемыми в литогра-фии терминами, все существующие стратегии по изменению свойств в заданной точке поверхно-сти можно разделить на два типа: масочные и без-масочные. В масочных методах изменение состава функциональных групп достигается путем воз-действия на поверхность через шаблоны, в то время как в безмасочных методах шаблоны отсут-ствуют.

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“…This is feasible by either patterning cell-adherent extracellular-matrix protein on the actuator or patterning protein repellent co-polymers such as poly-l-lysine grafted polyethylene glycol on the surface except on the actuators by microcontact printing [25,26].…”

Section: Actuation Principlementioning

confidence: 99%

Microfabrication and characterization of an array of dielectric elastomer actuators generating uniaxial strain to stretch individual cells

Akbari¹,

Shea²

2012

J. Micromech. Microeng.

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Cells regulate their behavior in response to mechanical strains. Cell cultures to study mechanotransuction are typically cm 2 in area, far too large to monitor single cell response. We have developed an array of dielectric elastomer microactuators as a tool to study mechanotransduction of individual cells. The array consists of 72 100 μm × 200 μm electroactive polymer actuators which expand uniaxially when a voltage is applied. Single cells will be attached on each actuator to study their response to periodic mechanical strains. The device is fabricated by patterning compliant microelectrodes on both sides of a 30 μm thick polydimethylsiloxane membrane, which is bonded to a Pyrex chip with 200 μm wide trenches. Low-energy metal ion implantation is used to make stretchable electrodes and we demonstrate here the successful miniaturization of such ion-implanted electrodes. The top electrode covers the full membrane area, while the bottom electrodes are 100 μm wide parallel lines, perpendicular to the trenches. Applying a voltage between the top and bottom electrodes leads to uniaxial expansion of the membrane at the intersection of the bottom electrodes and the trenches. To characterize the in-plane strain, an array of 4 μm diameter aluminum dots is deposited on each actuator. The position of each dot is tracked, allowing displacement and strain profiles to be measured as a function of voltage. The uniaxial strain reaches 4.7% at 2.9 kV with a 0.2 s response time, sufficient to stimulate most cells with relevant biological strains and frequencies.

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Microcontact printing of novel co-polymers in combination with proteins for cell-biological applications

Cited by 197 publications

References 26 publications

Surface Treatments to Modulate Bioadhesion: A Critical Review

Surface Treatments to Modulate Bioadhesion: A Critical Review

Methods of surface chemical patterning

Microfabrication and characterization of an array of dielectric elastomer actuators generating uniaxial strain to stretch individual cells

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