Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes

Lu, Bitao; Hu, Enling; Xie, Ruiqi; Yu, Kun; Lu, Fei; Bao, Rong; Wang, Chenhui; Lan, Guangqian; Dai, Fangyin

doi:10.1016/j.bioactmat.2022.01.002

Cited by 12 publications

(11 citation statements)

References 42 publications

(42 reference statements)

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“…The TH loading ratio and CaCO 3 loading content were approximately 25% and 5 U/g. Protonated tranexamic acid (TXA-NH 3 + ) was prepared as described in a previous study [ 13 ]. A 0.5 M tranexamic acid aqueous solution was prepared, and hydrochloric acid was used to adjust the pH to 4.0.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, micromotors with specific actuation mechanisms (e.g., magnetic navigation or gas-induced propulsion) for the effective active delivery of hemostats to deep bleeding sites have shown great potential for use in complex wounds with irregular shapes [ 11 , 12 ]. For example, in our previous study [ 13 ], we designed thrombin-loaded colloidosomes that could actively release drugs via micro-ravines and enhance drug penetration inside the wound cavity through magnetic navigation and gas propulsion. However, the physical propulsion thrust of this material remains a challenge in massive bleeding wounds, especially in large animal bleeding wound models, because of its poor resistance to high-rate blood fluids and inflexible application approaches.…”

Section: Introductionmentioning

confidence: 99%

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Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

Ding

et al. 2023

Research

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Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital settings. Thus, multiple hemostatic strategies are critical for treating large bleeding wounds. In this study, inspired by bombardier beetles to eject toxic spray for defense, a shape-memory aerogel with an aligned microchannel structure was proposed, employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug permeation. Bioinspired aerogels, after contact with blood, can rapidly expand inside the wound, offering robust physical barrier blocking, sealing the bleeding wound, and generating a spontaneous local chemical reaction causing an explosive-like generation of CO 2 microbubbles, which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug diffusion. The ejection behavior, drug release kinetics, and permeation capacity were evaluated using a theoretical model and experimentally demonstrated. This novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility, displaying great potential for clinical application in humans.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

Ding

et al. 2023

Research

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“…To facilitate the distribution of the drug at the bleeding site, magnetic navigation and gas propelling strategy were jointly used for delivering the drug into vase-type wounds. However, the acidic condition showed certain effect on wound healing, which needs to be further addressed [ 162 ]. Gelatinizable hemostatic powders have also been described.…”

Section: Form Design Of Hemostasis Materialsmentioning

confidence: 99%

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Zou¹,

Li²,

Hu³

et al. 2022

Materials Today Bio

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“…Colloidosomes, also known as Pickering emulsion microcapsules, have both hollow and self-assembly structures. − They have extensive applications in fabrics, − food, , medicine, , agriculture, and many other aspects. − The conventional preparation process of colloidosomes is to assemble latex particles at the oil–water interface, and the latex particles are then locked to form shells to encapsulate the active materials. − Colloidosomes can easily be functionalized depending upon the type of loaded nanoparticles with specific properties. − Among these functionalized structures, magnetic nanoparticle (NP)-loaded colloidosomes can be used as carriers to trigger the release of drugs, which can be remotely controlled by an external magnetic field. ,− The accumulation of the drug-loaded colloidosomes is rapid in a magnetic response pathological area, which can avoid side effects to normal cells. − …”

Section: Introductionmentioning

confidence: 99%

Three-Fluid Nozzle Spray Drying Strategy for Efficient Fabrication of Functional Colloidosomes

Liu

Jia

et al. 2022

Langmuir

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Colloidosomes as Pickering emulsion microcapsules are expected to serve various applications, including encapsulation of drugs and loading of functional materials. Normally, when using colloidosomes for drug encapsulation, the latex particles as shell materials need to be mixed with drugs before the assembly process. However, this procedure may cause aggregation of latex particles, thereby resulting in disordered assembled shells or a low loading efficiency. Herein, we propose a three-fluid nozzle spray drying process to efficiently assemble latex particles of P(styrene (St)-co-butyl acrylate (BA)) into colloidosomes. The three-fluid nozzle spray drying equipment allows for the preparation for drug encapsulation without advance mixing of drug and shell materials. This strategy enables the construction of colloidosomes with uniform and controllable pores and the loading of functional materials. The effects of the compressed air flow rate, inlet temperature, feed rate, and solid content were explored, revealing the formation mechanism of colloidosomes during the spray drying process. Doxycycline hydrochloride (DH) was encapsulated in colloidosomes for controllable release, and the sustained release time is up to 100 h. The release rate can be adjusted by varying the glass transition temperature (T g) and size of latex particles. Furthermore, Fe3O4 nanoparticle (NP)-loaded colloidosomes were constructed by this strategy. The magnetic response intensity of colloidosomes can be modulated by varying the amount of Fe3O4 NPs. The anticancer drug encapsulation and loading of other functional particles were also explored to expand applications.

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Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes

Cited by 12 publications

References 42 publications

Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Three-Fluid Nozzle Spray Drying Strategy for Efficient Fabrication of Functional Colloidosomes

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