Three-Fluid Nozzle Spray Drying Strategy for Efficient Fabrication of Functional Colloidosomes

Abstract

Colloidosomes as Pickering emulsion microcapsules are expected to serve various applications, including encapsulation of drugs and loading of functional materials. Normally, when using colloidosomes for drug encapsulation, the latex particles as shell materials need to be mixed with drugs before the assembly process. However, this procedure may cause aggregation of latex particles, thereby resulting in disordered assembled shells or a low loading efficiency. Herein, we propose a three-fluid nozzle spray drying process to efficiently assemble latex particles of P(styrene (St)-co-butyl acrylate (BA)) into colloidosomes. The three-fluid nozzle spray drying equipment allows for the preparation for drug encapsulation without advance mixing of drug and shell materials. This strategy enables the construction of colloidosomes with uniform and controllable pores and the loading of functional materials. The effects of the compressed air flow rate, inlet temperature, feed rate, and solid content were explored, revealing the formation mechanism of colloidosomes during the spray drying process. Doxycycline hydrochloride (DH) was encapsulated in colloidosomes for controllable release, and the sustained release time is up to 100 h. The release rate can be adjusted by varying the glass transition temperature (T g) and size of latex particles. Furthermore, Fe3O4 nanoparticle (NP)-loaded colloidosomes were constructed by this strategy. The magnetic response intensity of colloidosomes can be modulated by varying the amount of Fe3O4 NPs. The anticancer drug encapsulation and loading of other functional particles were also explored to expand applications.

Magnetic hollow micro-sized nanoaggregates for synergistically accelerating PET glycolysis

“…As can be seen, as the flow rate of compressed air increases, feed droplets are atomized at a smaller angle across the nozzle, thus reducing the loss of catalyst within the spray dryer. 31 However, if both the feed rate and the flow rate of compressed air are excessive, it will bring about incomplete evaporation of water, leading to undried products. 29 Hence, the proper preparation conditions for ZnO-Fe 3 O 4 HMNAs were determined as an inlet temperature of 120 °C and a feed rate of 0.54 L h −1 .…”

“…In the drying process, aqueous ZnO and Fe 3 O 4 composite nanodispersions are rapidly atomized and dried via compressed air, and then continuously assembled into ZnO-Fe 3 O 4 HMNAs with a regular structure and good dispersity. [29][30][31] Compared with individual ZnO and Fe 3 O 4 NPs, the spray-dried HMNAs exhibit ultrahigh efficiency. The NH 3 -TPD, pyridine-adsorption IR analysis and DFT study reveal the increased Lewis acidity and enhanced adsorption of PET over HMNAs, further confirming the structural synergy effect of ZnO-Fe 3 O 4 HMNAs.…”

Multifunctional, Hybrid Materials Design via Spray‐Drying: Much more than Just Drying

“…Indeed, conditions that promote rapid reaction and precipitation upon mixing of the reagents can lead to the formation of amorphous phases or unwanted species before spray‐drying even begins. This problem can be resolved through the use of a T‐junction connector or a three‐fluid nozzle, [ 40 ] attachments that shorten the contact time between the precursor solutions. [ 41,42 ] Contrarily, spray‐drying syntheses of MOFs containing high‐nuclearity clusters (e.g., zirconium‐oxo‐hydroxo clusters) that require longer reaction times may result in low yields and/or afford materials with poor sorption capabilities, due to fast drying‐kinetics.…”

BaSO4-Epoxy Resin Composite Film for Efficient Daytime Radiative Cooling

“…Nanodispersions are nanoparticles that can be uniformly dispersed in liquid media and remain stable over time. It is characterized by high dispersibility, small particle size, and narrow particle size distribution. − Compared with conventional nanopowders, nanoparticles existing in the dispersions are much easier to be dispersed in composites and show better nanoeffects and other application performance. − In order to obtain superior application properties, the use of highly dispersed nanoparticles to build a secondary structure should be considered. Nanoclusters are described as micrometer-sized aggregates of nanoparticles, which have the advantages of both microparticles and nanoparticles, showing the characteristics of high dispersibility and outstanding mechanical properties.…”