1992
DOI: 10.1679/aohc.55.453
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Microcirculation of the Rat Pancreas, with Special Reference to the Insulo-Acinar Portal and Insulo-Venous Drainage Systems: A Further Scanning Electron Microscope Study of Corrosion Casts.

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Cited by 35 publications
(30 citation statements)
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References 24 publications
(34 reference statements)
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“…Streptozotocin treatment resulted in an even uptake of 3H-leucine by pen-and tele-insular acinar cells with equal density of silver grains in their associated intercalated ducts. Based on these results, we have agreed with the previous authors (13,15) that the cells of peninsular acini are more active in protein synthesis than the cells of tele-insular acini, due to exposure of the former cells to high concentrations of insulin, which are caused by the blood flow directly from the islet capillaries toward pen-insular acini (4,(16)(17)(18)(19).…”
Section: Discussionsupporting
confidence: 90%
“…Streptozotocin treatment resulted in an even uptake of 3H-leucine by pen-and tele-insular acinar cells with equal density of silver grains in their associated intercalated ducts. Based on these results, we have agreed with the previous authors (13,15) that the cells of peninsular acini are more active in protein synthesis than the cells of tele-insular acini, due to exposure of the former cells to high concentrations of insulin, which are caused by the blood flow directly from the islet capillaries toward pen-insular acini (4,(16)(17)(18)(19).…”
Section: Discussionsupporting
confidence: 90%
“…In this way, both in vitro and in vivo results are consistent with ␦-cell SST exerting an inhibitory paracrine influence on islet ␣-and ␤-cells. The route through which ␦-cell SST reaches ␣-and ␤-cells is uncertain; early reports on islet blood flow do not support a vascular route from ␦-cells to ␣-and ␤-cells (35,36), although other data do imply a direct vascular route from ␦-to ␤-cells (37). Alternatively, SST delivery may be mediated by diffusion via interstitial compartments (38,39) independent of islet vasculature.…”
Section: Diabetes Vol 58 February 2009mentioning
confidence: 99%
“…Thus, islet hormones conveyed to the acinar epithelium via an islet-acinar portal circulation appear to modulate exocrine pancreatic secretion (see Williams & Goldfine, 1985;Murakami & Fujita, 1992). In pancreatic acinar cells, agonist-induced Ca2+ influx is required for regulation of cytosolic Ca2+, refilling of internal Ca2+ stores and secretion (Muallem, 1989).…”
Section: Introductionmentioning
confidence: 99%