“…While most of the studies showed a positive effect of insulin the results are complicated by changes in the precursor pool or changes in the levels of mRNAs. When protein synthesis in mice was quantitated by autoradiography, there was more incorporation into peri-insular acinar cells then into tele-insular acinar cells (7). This difference was lost following treatment with streptozotocin and the authors ascribed it to insulin.…”