Microcirculation and Structural Reorganization of the Bladder Mucosa in Chronic Cystitis under Conditions of Ozone Therapy

Неймарк, А. И.; Nepomnyashchikh, L. M.; Лушникова, Е. Л.; Bakarev, M. A.; Абдуллаев, Н. А.; Sizov, K A

doi:10.1007/s10517-014-2358-7

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…Because of its various effects on the body, ozonetherapy has been evaluated for efficacy and applied in treatment of several disorders, including osteomyelitis [ 11 ], chronic obstructive pulmonary disease [ 12 ], hepatitis [ 13 ], cystitis [ 14 , 15 ], rheumatoid arthritis [ 16 , 17 ], OA [ 18 – 25 ], back pain [ 26 – 28 ], multiple sclerosis [ 29 ], peritonitis [ 30 ], osseous defects [ 31 , 32 ], and coronary arterial disease [ 33 ]. Intra-articular ozonetherapy has been successfully used in human medicine for treatment of inflammatory diseases, chronic and acute, synovitis, capsulitis, and OA [ 16 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects

et al. 2018

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ObjectiveThe aim of this study was to verify whether transient inflammatory reactions induced by intra-articular medicinal ozone administration affect joint components, by in vivo evaluation of inflammatory (prostaglandin E2, Substance P, Interleukin-6, Interleukine-1, Tumor Necrosis Factor), anti-inflammatory (Interleukin-10) and oxidative (superoxide dismutase activity and oxidative burst) biomarkers and extracellular matrix degradation products (chondroitin sulphate and hyaluronic acid) in synovial fluid.MethodsThe effects of medicinal ozone were analyzed at two ozone concentrations (groups A and B, 20 and 40 μg/ml, respectively), using oxygen-injected joints as controls (group C); each group received ten treatments (15 ml gas per treatment). Physical evaluation, evaluation of lameness, ultrasonography, and synovial fluid analysis were performed.ResultsAll joints presented mild and transient effusion throughout the study. Group B exhibited the highest lameness score on day 14 (P<0.05), detected by the lameness measurement system, probably because of the higher ozone concentration. All groups exhibited increased ultrasonography scores on day 14 (P < 0.05). Groups A and B exhibited increased proteins concentrations on day 21 (P<0.05). There was no change in hyaluronic acid concentration or the percentage of high-molecular weight hyaluronic acid throughout the experiment. Chondroitin sulfate concentrations decreased in group B, and did not change in group A and C, indicating that neither treatment provoked extracellular matrix catabolism. Cytokine and eicosanoid concentrations were not significantly changed.ConclusionsThe ozonetherapy did not cause significant inflammation process or cartilage degradation, therefore, ozonetherapy is safe at both evaluated doses.

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Section: Introductionmentioning

confidence: 99%

Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects

et al. 2018

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“…That study agrees with the observations reported by Neimark et al evaluating the use of ozone in patients with chronic cystitis through microcirculation parameters and vesical morphological changes. The authors demonstrated a restructuring of the epithelial layer, with structural organization, reduction of the inflammatory process, and significant improvement of microcirculation in the bladder mucosa [ 28 ]. These observations may explain our results confirmed through the ICSI/ICPI scores.…”

Section: Discussionmentioning

confidence: 99%

“…The effects associated with moderate and transient oxidative stress triggered by ozone include the upregulation of the antioxidant system, homeostasis of NO, calcium, and inflammatory cytokines, and improvement in oxygen metabolism and immune modulation, as reported in clinical and preclinical studies [ 15 – 18 , 20 , 28 , 36 , 37 ]. Adverse reactions to ozone are mild and transient, contributing to the growing interest in its use in various pathologies, including IC/BPS.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of intravesical ozone in interstitial cystitis by the O'Leary–Sant symptom index

et al. 2022

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Introduction and hypothesis A prospective clinical, preliminary study was performed in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) who were nonresponders to conventional treatment and received intravesical ozone as a therapeutic alternative. Methods Sixteen patients received six applications of intravesical ozone at a concentration of 41 μg/mL. We evaluated therapeutic efficacy by the percentage reduction of Interstitial Cystitis Symptom and Problem Index scores (ICSI/ICPI—the O'Leary–Sant symptom index), recurrence rate, nonresponse, and side effects in scores collected on admission (pre-treatment), at the end of the therapeutic protocol (post-treatment), and 180 days (follow-up) after the last ozone application. Results The mean age of women was 52.9 years (SD: 15.5), and the duration of symptoms was 5.7 years (SD: 7.1). The median ICSI on admission was 17 (IQR: 14.25–19.5) and at follow-up was 0.5 (IQR: 0–2), with a reduction of 97.5% (CI: 85.7–100). The median ICSI/ICPI on admission was 31.5 (IQR: 29–35.2) and at follow-up was 2.0 (IQR: 0–3.75), with a reduction of 92.3% (CI: 88.8–100). The recurrence rate was only 6.25%, and no patients were nonresponders to the treatment. Conclusions The application of intravesical ozone was effective in the treatment of patients with IC/BPS who were nonresponders to conventional therapy, showing a progressive and safe effect, at least in the short term. Supplementary Information The online version contains supplementary material available at 10.1007/s00192-022-05383-3.

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“…Total ozone dose is equal to the product of gas volume (ml) and ozone concentration (µg/ml). According to the European Union, the ozone generators are treated as sanitary products possessing II-b quali ication, and it should be registered with a known entity under a noti ied manufacturer (Neimark et al, 2014). Compared to oxygen, ozone is more powerful oxidant; practically, it can oxidise various non-organic and organic compounds.…”

Section: Introductionmentioning

confidence: 99%

Current Trends Of ESRD Patients with Ozonedialysis: Ozone “The Wonder Therapy” For Dialysis

Kavitha¹,

Jeyalakshmi²,

Sridevy³

et al. 2020

ijrps

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Ozone therapy is known to be the current successful method of dialysis which is first taken up in Germany. Medical oxygen known to be an ataxic generator is used to generate medical ozone, ensuring the inert contact of all the materials related to ozone. Surprisingly this useful and effective therapy is not recognised in our country like India but is widely accepted and practised in the countries like South America, Europe, Russia, Thailand, Bulgaria, Indonesia, Cuba, etc.; since over 70 years it is used as a successful method of treating various illnesses; like used to halt the progression of diabetes, Kidney diseases, detoxification of the body, coronary artery disease, etc.; Ozone is prepared freshly "on-site" just before starting the session, as it should be administrated immediately after its generation. They should be accurate, reliable and should project the ozone concentration (1-80μg/ml) as reproducible measurements by using a suitable device. Ozone Therapy has learnt to be an effective therapy for ESRD patients irrespective of the stages of disease dealt. The importance and the applications of Ozone therapy in the current medical field are discussed and emphasised in the present review. This review may help the researchers in planning further research to improvise the therapy or to sophisticate the method of implementation, and it also helps in delivering details of the therapy for better understanding of the medical practitioners.

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Microcirculation and Structural Reorganization of the Bladder Mucosa in Chronic Cystitis under Conditions of Ozone Therapy

Cited by 9 publications

References 6 publications

Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects

Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects

Effectiveness of intravesical ozone in interstitial cystitis by the O'Leary–Sant symptom index

Current Trends Of ESRD Patients with Ozonedialysis: Ozone “The Wonder Therapy” For Dialysis

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