Microbiota and Myopericarditis: The New Frontier in the Car-Diological Field to Prevent or Treat Inflammatory Cardiomyo-Pathies in COVID-19 Outbreak

Piccioni, Andrea; Saviano, Angela; Cicchinelli, Sara; Franza, Laura; Rosa, Federico; Zanza, Christian; Santoro, Michele; Candelli, Marcello; Covino, Marcello; Nannini, Giulia; Amedei, Amedeo; Franceschi, Francesco

doi:10.3390/biomedicines9091234

Cited by 14 publications

(13 citation statements)

References 79 publications

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“…The microbiota of the gut is the most abundant, consisting of over one thousand resident microorganisms, mostly bacteria. Among these bacteria, the main phyla are Firmicutes , Proteobacteria , and Bacteroidetes [ 5 ]. The relationship between the microbiota and its host is as complex as it is fascinating: it is established from the earliest moments of life, then influenced over the years by multiple environmental factors, such as diet, physical activity, genetics, chemical, and physical agents [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Smoking on Microbiota: A Narrative Review

et al. 2023

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Cigarette smoke is a classic risk factor for many diseases. The microbiota has been recently indicated as a new, major player in human health. Its deregulation—dysbiosis—is considered a new risk factor for several illnesses. Some studies highlight a cross-interaction between these two risk factors—smoke and dysbiosis—that may explain the pathogenesis of some diseases. We searched the keywords “smoking OR smoke AND microbiota” in the title of articles on PubMed®, UptoDate®, and Cochrane®. We included articles published in English over the last 25 years. We collected approximately 70 articles, grouped into four topics: oral cavity, airways, gut, and other organs. Smoke may impair microbiota homeostasis through the same harmful mechanisms exerted on the host cells. Surprisingly, dysbiosis and its consequences affect not only those organs that are in direct contact with the smoke, such as the oral cavity or the airways, but also involve distant organs, such as the gut, heart, vessels, and genitourinary tract. These observations yield a deeper insight into the mechanisms implicated in the pathogenesis of smoke-related diseases, suggesting a role of dysbiosis. We speculate that modulation of the microbiota may help prevent and treat some of these illnesses.

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Section: Introductionmentioning

confidence: 99%

The Impact of Smoking on Microbiota: A Narrative Review

et al. 2023

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“…It is now clear how the gut microbiota is a fundamental constituent of the human organism. This superorganism, whose development is affected by countless factors, is increasingly implicated in the pathogenesis of various diseases [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship

et al. 2023

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There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of diabetes mellitus type 1 and LADA, in light of the latest evidence. We will then look at both how the role of the gut microbiota appears to be increasingly crucial in the pathogenesis of these disorders and how this aspect may be instrumental in the development of new potential therapeutic strategies that modulate the gut microbiota, such as probiotics, prebiotics, and fecal microbiota transplantation.

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“…Gut microbiome modulation may moderate this effect [ 48 ]. A comprehensive review suggests that microbiome alterations could diminish the number and severity of myocardial disorders associated with COVID infection [ 49 ].…”

Section: Value Of Greatly Improved Pre-vaccine Evaluationmentioning

confidence: 99%

Potential Immunologic and Integrative Methods to Enhance Vaccine Safety

Dattner¹

2022

Vaccines

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Vaccine safety is measured by the disease protection it confers compared to the harm it may cause; both factors and their relative numbers have been the subject of disagreement. Cross-reactive attack of analogous self-antigens modified by dietary and microbiome factors is one of the poorly explored likely causes of harm. Screening for that and other risk factors might point out those most likely to develop severe vaccine reactions. Cooperation from those with opinions for and against vaccination in data gathering and vetting will lead to greater safety. Screening should include an integrative medical perspective regarding diet, microbiome, leaky gut, and other antigen sources. It might include emerging electronic technology or integrative energetic techniques vetted ultimately by cross-reactive lymphocyte testing or genetic evaluation. The knowledge gained from evaluating those with reactions could enhance the screening process and, since similar antigenic stimuli and reactions are involved, help long COVID sufferers. Centers for early identification and rescue from vaccine reactions could lower morbidity and mortality, and increase the percentage of people choosing to be vaccinated. Additional platforms for boosting; using lower dosage; other routes of administration, such as intranasal or intradermal needles; and possibly different antigens could make it easier to vaccinate globally to address the new variants of viruses rapidly arising.

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Microbiota and Myopericarditis: The New Frontier in the Car-Diological Field to Prevent or Treat Inflammatory Cardiomyo-Pathies in COVID-19 Outbreak

Cited by 14 publications

References 79 publications

The Impact of Smoking on Microbiota: A Narrative Review

The Impact of Smoking on Microbiota: A Narrative Review

Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship

Potential Immunologic and Integrative Methods to Enhance Vaccine Safety

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