Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship

Piccioni, Andrea; Rosa, Federico; Mannucci, Sergio; Manca, Federica; Merra, Giuseppe; Chiloiro, Sabrina; Candelli, Marcello; Covino, Marcello; Gasbarrini, Antonio; Franceschi, Francesco

doi:10.3390/biomedicines11030707

Cited by 11 publications

(5 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The gut microbiota is one of the most evolving fields of medicine in recent years [63], which is increasingly fascinating researchers worldwide.…”

Section: Discussionmentioning

confidence: 99%

Coffee and Microbiota: A Narrative Review

Rosa,

Marigliano,

Mannucci

et al. 2024

CIMB

Self Cite

View full text Add to dashboard Cite

Coffee is one of the most widely consumed beverages in the world, which has important repercussions on the health of the individual, mainly because of certain compounds it contains. Coffee consumption exerts significant influences on the entire body, including the gastrointestinal tract, where a central role is played by the gut microbiota. Dysbiosis in the gut microbiota is implicated in the occurrence of numerous diseases, and knowledge of the microbiota has proven to be of fundamental importance for the development of new therapeutic strategies. In this narrative review, we thoroughly investigated the link between coffee consumption and its effects on the gut microbiota and the ensuing consequences on human health. We have selected the most significant articles published on this very interesting link, with the aim of elucidating the latest evidence about the relationship between coffee consumption, its repercussions on the composition of the gut microbiota, and human health. Based on the various studies carried out in both humans and animal models, it has emerged that coffee consumption is associated with changes in the gut microbiota, although further research is needed to understand more about this link and the repercussions for the whole organism.

show abstract

“…The gut microbiota is one of the most evolving fields of medicine in recent years [63], which is increasingly fascinating researchers worldwide.…”

Section: Discussionmentioning

confidence: 99%

Coffee and Microbiota: A Narrative Review

Rosa,

Marigliano,

Mannucci

et al. 2024

CIMB

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies have been conducted on the microbiota in diabetes associated with developing acute peritonitis (Ortega et al, 2020;Craciun et al, 2022;Piccioni et al, 2023). Toniolo et al (2019) associated bacteremia and sepsis with this disorder of carbohydrate metabolism with Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Enterobacteriaceae, Enterococci, Pseudomonas aeruginosa, Candida albicans.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and changes in cytokine profile in animals with experimental acute disseminated peritonitis on the background of diabetes

Verveha,

Gutyj,

Holubiev

et al. 2023

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

In the pathogenesis of acute widespread peritonitis and accompanying diabetes, a vital link is an endogenous intoxication caused by the translocation of microorganisms and their toxins from the intestine into the blood, metabolic changes, and immunological reactivity of the body. Our work aimed to investigate the microbial composition in the parietal intestinal biotope and the features of the blood cytokine profile in animals with acute disseminated peritonitis on the background of streptozotocin-induced diabetes. The study was conducted on 56 sexually mature non-linear white male rats. Diabetes mellitus was modeled by a single intraperitoneal injection of streptozotocin (60 mg/kg). On the 14th day of the development of streptozotocin-induced diabetes mellitus, a 10% filtered fecal suspension (0.5 mL) was injected into the abdominal cavity of animals, and acute generalized peritonitis was initiated. Sowing on nutrient media was carried out for bacteriological research to isolate a pure culture of microorganisms and their identification. The concentration of TNF-α, IL-1β, and IL-6 was studied by solid-phase enzyme immunoassay. The research results demonstrate an imbalance of cytokines in the dynamics of experimental acute disseminated peritonitis against the background of diabetes and quantitative and qualitative changes in the microbiota of the parietal intestinal biotope. A decrease in the number of Escherichia coli strains isolated in monoculture and an increase in the number of two-component and three-component microbial associations were revealed, among which Enterobacter aerogenes, Escherichia coli, Bacteroides spp., Proteus mirabilis, Klebsiella spp. and Candida species prevailed.

show abstract

“…The impact of smoking on the gastrointestinal system has been extensively examined as a potential risk factor for cancer, as noted by Cicchinelli et al (2023). Commencing with studies using animal models, researchers have observed that mice exposed to smoke exhibited dysbiosis in the gut microbiota, leading to an elevated occurrence of colorectal cancer.…”

Section: Health Implication Of Findingsmentioning

confidence: 99%

Impact of cigarette smoking on gut microbial dysbiosis: a structured literature review

Imade,

Obayagbona

2024

Gut. Microb.

View full text Add to dashboard Cite

The gut microbiota comprises microorganisms in the human gastrointestinal tract.Lifestyle choices like smoking lead to gut dysbiosis. This review assessed the effect of cigarette smoke on gut microbial dysbiosis in active smokers compared to nonsmokers, as well as the resulting public health implications. A comprehensive search was conducted using the Cumulative Index for Nursing and Allied Health (CINAHL), Medline, and PubMed. The search result was reported following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines. The CASP (Critical Appraisal Skills Programme) tool was used to evaluate the recruited studies. There were 468 articles found, with 17 of them qualifying for fulltext screening. Five of these studies were included in the review. Smoke harmed gut microbe proportions; smokers had more Bacteroidetes and less Firmicutes than nonsmokers, affecting their Firmicutes/Bacteroidetes ratio. This has significant public health implications. Organisms enriched in the smokers such as Bacteroidales

show abstract

Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship

Cited by 11 publications

References 75 publications

Coffee and Microbiota: A Narrative Review

Coffee and Microbiota: A Narrative Review

Gut microbiota and changes in cytokine profile in animals with experimental acute disseminated peritonitis on the background of diabetes

Impact of cigarette smoking on gut microbial dysbiosis: a structured literature review

Contact Info

Product

Resources

About