Microbiota and Malodor—Etiology and Management

Mogilnicka, Izabella; Bogucki, Pawel; Ufnal, Marcin

doi:10.3390/ijms21082886

Cited by 53 publications

(39 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accordingly, we define them as biofilm CAGs. Streptococcus , a biofilm CAG, has promising results in treatment of halitosis, which often concurrent with digestive tract microbial disorders during the colorectal carcinogenesis 53 , 54 . In this study, the decrease of Streptococcus in the oral cavity of CRA group may contribute to microbiota dysbiosis-associated colorectal carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer

et al. 2020

View full text Add to dashboard Cite

Background: The oral microbiome may play an important role in colorectal carcinogenesis. However, few studies have investigated the association between oral microbiome and the development of colorectal cancer (CRC). We aimed to investigate whether oral health-colorectal tumor association has an underlying microbial basis, in the quest for novel non-invasive biomarkers for CRC. Methods: We collected oral swab samples from 161 patients with CRC, 34 patients with colorectal adenoma (CRA), and 58 healthy volunteers. The oral microbiota was assessed using 16S rRNA sequencing. We characterized oral microbiome, identified microbial markers, constructed and validated colorectal tumor (CRA and CRC) classifier. Results: Oral microbial composition and diversity were significantly different among the three groups, and the CRA group had the highest diversity. Analysis of the functional potential of oral microbiota demonstrated that the pathway involving cell motility was overrepresented in the CRA and CRC groups relative to that in the healthy controls. Moreover, a random forest model was constructed based on oral microbial markers, which could distinguish the colorectal tumor groups from the healthy controls and achieve a powerful classification potential in the discovery and validation cohorts. Conclusion: This study suggests a potential association between oral microbiome dysbiosis and colorectal cancer. Oral microbiota-based biomarkers may be helpful in predicting the risks for the development of CRA and CRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Patients suffering from bad smell can adopt various atypical behaviors minimizing social interactions. This can lead to anxiety, decreased self-esteem, and low quality of life due to social difficulties, e.g., avoiding intimacy [ 67 , 68 ]. Overall, the potent antimicrobial action of esculentin peptides, especially of Esc(1-21) [MIC, 0.125 µM], and their safety profile make them attractive molecules for therapeutic and/or cosmetic application.…”

Section: Discussionmentioning

confidence: 99%

Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities

et al. 2020

View full text Add to dashboard Cite

Corynebacterium jeikeium is a commensal bacterium that colonizes human skin, and it is part of the normal bacterial flora. In non-risk subjects, it can be the cause of bad body smell due to the generation of volatile odorous metabolites, especially in the wet parts of the body that this bacterium often colonizes (i.e., groin and axillary regions). Importantly, in the last few decades, there have been increasing cases of serious infections provoked by this bacterium, especially in immunocompromised or hospitalized patients who have undergone installation of prostheses or catheters. The ease in developing resistance to commonly-used antibiotics (i.e., glycopeptides) has made the search for new antimicrobial compounds of clinical importance. Here, for the first time, we characterize the antimicrobial activity of some selected frog skin-derived antimicrobial peptides (AMPs) against C. jeikeium by determining their minimum inhibitory and bactericidal concentrations (MIC and MBC) by a microdilution method. The results highlight esculentin-1b(1-18) [Esc(1-18)] and esculentin-1a(1-21) [Esc(1-21)] as the most active AMPs with MIC and MBC of 4–8 and 0.125–0.25 µM, respectively, along with a non-toxic profile after a short- and long-term (40 min and 24 h) treatment of mammalian cells. Overall, these findings indicate the high potentiality of Esc(1-18) and Esc(1-21) as (i) alternative antimicrobials against C. jeikeium infections and/or as (ii) additives in cosmetic products (creams, deodorants) to reduce the production of bad body odor.

show abstract

“…Table 1. Volatile compounds present in halitosis [23,[30][31][32][33]44,47,48]. Aydin and Harvey-Woodworth divided pathologic halitosis into five types: Type 1 (oral), Type 2 (airway), Type 3 (gastroesophageal), Type 4 (blood-borne) and Type 5 (subjective).…”

Section: Volatile Compoundsmentioning

confidence: 99%

“…Significant contributors to methyl mercaptan production are also gut bacteria, which can be inhabitants of the oral cavity, such as E. coli , Citrobacter spp., and Proteus spp. [ 48 , 84 ].…”

Section: Microbiota Responsible For Intra-oral Halitosismentioning

confidence: 99%

The Role of Oral Microbiota in Intra-Oral Halitosis

Hampelska

Jaworska

Babalska

et al. 2020

JCM

View full text Add to dashboard Cite

Halitosis is a common ailment concerning 15% to 60% of the human population. Halitosis can be divided into extra-oral halitosis (EOH) and intra-oral halitosis (IOH). The IOH is formed by volatile compounds, which are produced mainly by anaerobic bacteria. To these odorous substances belong volatile sulfur compounds (VSCs), aromatic compounds, amines, short-chain fatty or organic acids, alcohols, aliphatic compounds, aldehydes, and ketones. The most important VSCs are hydrogen sulfide, dimethyl sulfide, dimethyl disulfide, and methyl mercaptan. VSCs can be toxic for human cells even at low concentrations. The oral bacteria most related to halitosis are Actinomyces spp., Bacteroides spp., Dialister spp., Eubacterium spp., Fusobacterium spp., Leptotrichia spp., Peptostreptococcus spp., Porphyromonas spp., Prevotella spp., Selenomonas spp., Solobacterium spp., Tannerella forsythia, and Veillonella spp. Most bacteria that cause halitosis are responsible for periodontitis, but they can also affect the development of oral and digestive tract cancers. Malodorous agents responsible for carcinogenesis are hydrogen sulfide and acetaldehyde.

show abstract

Microbiota and Malodor—Etiology and Management

Cited by 53 publications

References 148 publications

Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer

Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer

Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities

The Role of Oral Microbiota in Intra-Oral Halitosis

Contact Info

Product

Resources

About