Microbiosis in pathogenesis and intervention of atopic dermatitis

Dou, Jianhua; Zeng, Jinrong; Wu, Kathy; Tan, Wenbin; Gao, Lihua; Lu, Jianyun

doi:10.1016/j.intimp.2019.01.030

Cited by 10 publications

(8 citation statements)

References 79 publications

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“…El microbioma de la piel normal humana se compone de, al menos, 19 filos taxonómicos donde predominan el Actinobacteria, Firmicutes, Proteobacteria y Bacteroides, en estos filos los tres géneros más abundantes son Propionibacterium, Corynebacterium y Staphylococcus (1,2,4,5,8,9,11,12,15). En los sitios húmedos predomina la colonización de Staphylococcus y Corynebacterium (1,8,11), mientras que Propionibacterium, por ser una bacteria lipofílica, tiende a colonizar áreas sebáceas (1,6,8,11,14).…”

Section: Composición De Microbiomaunclassified

“…En niños, la colonización cutánea por S. epidermidis y S. cohnii durante el primer año de vida brinda efecto protector en el desarrollo de DA (24). Se fundamenta lo anteriormente expuesto, ya que S. epidermidis produce un compuesto con efecto inhibitorio sobre S.aureus (2,5,8,10,11,14,15,18,26), además, el ácido lipoteicoico producido por este organismo suprime la inflamación producto del daño tisular (10,11). Otros autores como Hon et al, por el contrario, demostraron que la presencia de S. epidermidis se asoció con enfermedad más severa (11).…”

Section: Rol De La Filagrinaunclassified

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Microbioma cutáneo, disbiosis y su rol en dermatitis atópica

Guzmán¹,

Orias

2020

Rev.méd.sinerg.

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El microbioma cutáneo está compuesto por una variedad extensa de microorganismos, este se ve modificado por diversos factores y es dinámico, ya que existen variaciones a lo largo de la vida. Los microorganismos y el huésped viven bajo una relación de simbiosis, en el momento que este sistema se rompe, se produce la disbiosis y esta tiene una influencia importante en la dermatitis atópica. Se reporta que existe un alta colonizacion de los pacientes enfermos por el Staphylococcus aureus y esto concuerda con la mayoría de los estudios donde se determina el microbioma de piel lesional y no lesional de pacientes con dermatitis atópica. Otros factores como las mutaciones en la proteína filagrina aumentan la susceptibilidad de colonización por S.aureus. Por otro lado, también se han encontrado agentes microbianos con capacidades inhibitorias sobre los microorganismos patógenos y se les ha atribuido un rol protector; este hallazgo motivó a algunos autores a utilizarlos como tratamientos alternativos e inclusive en uso combinado con terapia tópica como los emolientes. Adicionalmente, se reporta el restablecimiento de la microbiota con tratamientos convencionales como los humectantes, corticoesteroides, inhibidores de calcineurina y fototerapia. Múltiples estrategias se han estudiado con el fin de restablecer la biodiversidad cutánea en un intento de buscar tratamientos eficaces que actúan sobre la modificación de los procesos de disbiosis asociados con esta enfermedad.

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Section: Composición De Microbiomaunclassified

Section: Rol De La Filagrinaunclassified

Microbioma cutáneo, disbiosis y su rol en dermatitis atópica

Guzmán¹,

Orias

2020

Rev.méd.sinerg.

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“…Atopic dermatitis (AD) is a common pediatric inflammatory skin condition. Loss of function mutations in profilaggrin ( FLG ; 26.7% of patients), immune dysfunction, and bacterial dysbiosis have been linked to AD disease severity . Here, six studies focused on elucidating the factors contributing to the skin microbiome dysbiosis in the pediatric population are reviewed.…”

Section: Atopic Dermatitismentioning

confidence: 99%

“…Loss of function mutations in profilaggrin (FLG; 26.7% of patients), immune dysfunction, and bacterial dysbiosis have been linked to AD disease severity. [60][61][62] Here, six studies focused on elucidating the factors contributing to the skin microbiome dysbiosis in the pediatric population are reviewed. The impact of current AD therapies on the skin microbiome are also highlighted.…”

Section: Atopi C Dermatitismentioning

confidence: 99%

Skin microbiota: Friend or foe in pediatric skin health and skin disease

Schneider

Nelson

2019

Pediatric Dermatology

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The human integument and gastrointestinal tract host unique microbial ecosystems. Within the last decade, research has focused on understanding the contributions of the microbiota to human health and disease. The majority of skin microbiome studies involve adults. This review focuses on key studies conducted within the pediatric population and provides a framework for future skin microbiome work in this ever‐expanding field. This article begins by exploring the skin microbiome at birth and reviews the impact of delivery mode on infant skin colonization. How skin microbial colonization evolves from infancy to adulthood and normal development impacts the abundance of skin commensals such as Streptococcus, Staphylococcus, and Cutibacterium is also highlighted. Finally, several skin microbiome research studies in common pediatric skin conditions are reviewed, including body odor, atopic dermatitis (AD), and acne. The bacteria involved in metabolizing sweat, the impact on body odor, and how this process evolves from childhood to adulthood is outlined. In AD, different bacteria genera that predominate in children and adults and the impact of current AD therapies on skin microbiota are explored. Finally, in acne, the understanding of how Cutibacterium acnes contributes to acne pathogenesis and how acne therapies impact the skin microbial communities is reviewed.

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“…The gastrointestinal tract confers a natural anaerobic environment conducive to colonization. 9 Reciprocally, the gut microbiome exerts important effects on host physiology, including controlling post-translational modifications of the host proteome, 10 stimulating immune system development and homeostasis, 11,12 maintaining intestinal barrier integrity, 13 reaping inaccessible nutrients from the diet, 14 synthesizing certain essential vitamins and neurotransmitters, 15 modulating neurobehavioral properties, 16,17 endocrine functions 18 and bone density, 19 and even participating in drug biotransformation. 20,21 Multiple factors can lead to a loss of beneficial microbes and a reduction in microbial diversity, ultimately triggering gut dysbiosis (microbial imbalance or maladaptation).…”

Section: Introductionmentioning

confidence: 99%

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Zhang

Tang

Chen

et al. 2019

Sig Transduct Target Ther

184

151

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The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology. Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy. Given the plasticity in microbial composition and function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, and probiotics, as well as fecal microbial transplantation, potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes. Herein, we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism, the effects of the microbiome on extraintestinal cancers and the immune response, and strategies to modulate the gut microbiome, and we discuss ongoing studies and future areas of research that deserve focused research efforts.

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Microbiosis in pathogenesis and intervention of atopic dermatitis

Cited by 10 publications

References 79 publications

Microbioma cutáneo, disbiosis y su rol en dermatitis atópica

Microbioma cutáneo, disbiosis y su rol en dermatitis atópica

Skin microbiota: Friend or foe in pediatric skin health and skin disease

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

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