Microbiome Related Cytotoxically Active CD8+ TIL Are Inversely Associated With Lung Cancer Development

Zheng, Liping; Xu, Jiaqi; Sai, Buqing; Zhu, Yinghong; Wang, Lujuan; Yin, Na; Yu, Fenglei; Zhou, Wen; Wu, Minghua; Tang, Jingqun; Xiang, Juanjuan

doi:10.3389/fonc.2020.531131

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Therefore, CD8+ T cells are considered an important barrier to the long-term survival of organ allografts [ 34 , 35 ]. A previous study showed a strong positive relationship between Pasteurella and the infiltration of CD8+ T cells in patients with lung cancer [ 36 ]. However, in this study, we were unable to confirm the relationship between specific bacteria and CD8+ T cells due to the small number of patients.…”

Section: Discussionmentioning

confidence: 99%

Unique Changes in the Lung Microbiome following the Development of Chronic Lung Allograft Dysfunction

Yu,

Kim,

Cho

et al. 2024

Microorganisms

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The importance of lung microbiome changes in developing chronic lung allograft dysfunction (CLAD) after lung transplantation is poorly understood. The lung microbiome–immune interaction may be critical in developing CLAD. In this context, examining alterations in the microbiome and immune cells of the lungs following CLAD, in comparison to the lung condition immediately after transplantation, can offer valuable insights. Four adult patients who underwent lung retransplantation between January 2019 and June 2020 were included in this study. Lung tissues were collected from the same four individuals at two different time points: at the time of the first transplant and at the time of the explantation of CLAD lungs at retransplantation due to CLAD. We analyzed whole-genome sequencing using the Kraken2 algorithm and quantified the cell fractionation from the bulk tissue gene expression profile for each lung tissue. Finally, we compared the differences in lung microbiome and immune cells between the lung tissues of these two time points. The median age of the recipients was 57 years, and most (75%) had undergone lung transplants for idiopathic pulmonary fibrosis. All patients were administered basiliximab for induction therapy and were maintained on three immunosuppressants. The median CLAD-free survival term was 693.5 days, and the median time to redo the lung transplant was 843.5 days. Bacterial diversity was significantly lower in the CLAD lungs than at transplantation. Bacterial diversity tended to decrease according to the severity of the CLAD. Aerococcus, Caldiericum, Croceibacter, Leptolyngbya, and Pulveribacter genera were uniquely identified in CLAD, whereas no taxa were identified in lungs at transplantation. In particular, six taxa, including Croceibacter atlanticus, Caldiserium exile, Dolichospermum compactum, Stappia sp. ES.058, Kinetoplastibacterium sorsogonicusi, and Pulveribacter suum were uniquely detected in CLAD. Among immune cells, CD8+ T cells were significantly increased, while neutrophils were decreased in the CLAD lung. In conclusion, unique changes in lung microbiome and immune cell composition were confirmed in lung tissue after CLAD compared to at transplantation.

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Section: Discussionmentioning

confidence: 99%

Unique Changes in the Lung Microbiome following the Development of Chronic Lung Allograft Dysfunction

Yu,

Kim,

Cho

et al. 2024

Microorganisms

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“…Recently, a study revealed that Pasteurella has a positive correlation with cytotoxic CD8+ TILs and a negative correlation with M2 macrophages. There is a significant positive correlation between Coriobacteriaceae and M2 macrophages and a negative correlation with CD8+ cells [60]. Together, these immune reactions affect the occurrence and development of lung tumors.…”

Section: Immunitymentioning

confidence: 98%

The Role of Respiratory Microbiota in Lung Cancer

Wang¹,

Cheng²,

Zhang³

et al. 2021

Int. J. Biol. Sci.

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Recently, the impact of microorganisms on tumor growth and metastasis has attracted great attention. The pathogenesis and progression of lung cancer are related to an increase in respiratory bacterial load as well as changes in the bacterial community because the microbiota affects tumors in many ways, including canceration, metastasis, angiogenesis, and treatment. The microbiota may increase tumor susceptibility by altering metabolism and immune responses, promoting inflammation, and increasing toxic effects. The microbiota can regulate tumor metastasis by altering multiple cell signaling pathways and participate in tumor angiogenesis through vascular endothelial growth factors (VEGF), endothelial cells (ECs), inflammatory factors and inflammatory cells. Tumor angiogenesis not only maintains tumor growth at the primary site but also promotes tumor metastasis and invasion. Therefore, angiogenesis is an important mediator of the interaction between microorganisms and tumors. The microbiota also plays a part in antitumor therapy. Alteration of the microbiota caused by antibiotics can regulate tumor growth and metastasis. Moreover, the microbiota also influences the efficacy and toxicity of tumor immunotherapy and chemotherapy. Finally, the effects of air pollution, a risk factor for lung cancer, on microorganisms and the possible role of respiratory microorganisms in the effects of air pollution on lung cancer are discussed.

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“…All these immune responses influence the initiation and development of lung tumours. 201 Certain microorganisms, such as Staphylococcus aureus , HBV, and HCV, potentially promote the progression of prostate and liver cancers by promoting the immunosuppression mediated by T regulatory cells (Tregs). 202 – 204 Moreover, a large number of Tregs have been observed in HPV-induced cervical lesions, and the level of Tregs is associated with the severity of the disease, suggesting that Tregs may be involved in the interference of anti-HPV immune response.…”

Section: Role Of Intratumoural Microbiota In the Development Of Cancermentioning

confidence: 99%

Intratumoural microbiota: a new frontier in cancer development and therapy

Cao,

Xia,

Tan

et al. 2024

Sig Transduct Target Ther

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Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological and pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms, which have been confirmed to be closely related to oncogenesis. The concept of intratumoural microbiota was subsequently proposed. Microbiota could colonise tumour tissues through mucosal destruction, adjacent tissue migration, and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour microenvironment. Mechanistic studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations, affecting epigenetic modifications, promoting inflammation response, avoiding immune destruction, regulating metabolism, and activating invasion and metastasis. Since more comprehensive and profound insights about intratumoral microbiota are continuously emerging, new methods for the early diagnosis and prognostic assessment of cancer patients have been under examination. In addition, interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy, especially immunotherapy, although there are some inevitable challenges. Here, we aim to provide an extensive review of the concept, development history, potential sources, heterogeneity, and carcinogenic mechanisms of intratumoural microorganisms, explore the potential role of microorganisms in tumour prognosis, and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field.

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Microbiome Related Cytotoxically Active CD8+ TIL Are Inversely Associated With Lung Cancer Development

Cited by 9 publications

References 28 publications

Unique Changes in the Lung Microbiome following the Development of Chronic Lung Allograft Dysfunction

Unique Changes in the Lung Microbiome following the Development of Chronic Lung Allograft Dysfunction

The Role of Respiratory Microbiota in Lung Cancer

Intratumoural microbiota: a new frontier in cancer development and therapy

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