Microbiome bacterial influencers of host immunity and response to immunotherapy

Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children

“…In addition to these functions, GM also modulates the functions of the central nervous system, in which the metabolites released by the microbiota influence mood, stress regulation, and instinctive behaviors on the cardiovascular and endocrine-metabolic systems; the cardiovascular system is also modulated by GM through disease risk factors that cause hyperlipidemia, atherosclerosis, and type 2 diabetes and the digestive system through the action of microbiota products absorbed from the intestine and transferred to the liver (see Figure 1) [38]. Thus, GM also impacts the individual's physical and mental health.…”

“…However, even if generally considered beneficial, some GM microbes can cause a potential danger to the human organism [37]. When the homeostasis of the microbiota is disturbed, most of it becomes pathogenic, in which remodeling occurs that alters the sophisticated balance of the microecosystem in the gastrointestinal tract, contributing to a variety of pathological conditions and negatively affecting the physiological processes of the host [38]. This imbalance, called "microbial dysbiosis", shows a reduction in microbes favorable to the health of the host and an excessive presence of pathogenic microbes with deleterious functions [39].…”