Microbiologic characteristics and antibiotic resistance rates of diabetic foot infections

Abstract

Purpose: the purpose of this research was to identify the sociodemographic and microbiological characteristics and antibiotic resistance rates of patients with diabetic foot infections, hospitalized in an emergency reference center. Methods: it was an observational and transversal study. The sociodemographic data were collected by direct interview with the patients. During the surgical procedures, specimens of tissue of the infected foot lesions were biopsied to be cultured, and for bacterial resistance analysis. Results: the sample consisted of 105 patients. The majority of patierns were men, over 50 years of age, married and with low educational level. There was bacterial growth in 95 of the 105 tissue cultures. In each positive culture only one germ was isolated. There was a high prevalence of germs of the Enterobacteriaceae family (51,5%). Gram-negative germs were isolated in 60% of cultures and the most individually isolated germs were the Gram-positive cocci, Staphylococcus aureus (20%) and Enterococcus faecalis (17,9%). Regarding antibiotic resistance rates, a high frequency of Staphylococcus aureus resistant to methicillin (63,0%) and to ciprofloxacin (55,5%) was found; additionally, 43,5% of the Gram-negative isolated germs were resistant to ciprofloxacin. Conclusions: the majority of patients were men, over 50 years of age, married and with low educational level. The most prevalent isolated germs from the infected foot lesions were Gram-negative bacteria, resistant to ciprofloxacin, and the individually most isolated germ was the methicillin resistant Staphylococcus aureus.

Identification and antibiotic susceptibility of microorganisms isolated from diabetic foot ulcers: A pathological aspect

“…Uncontrolled diabetes or improper management of it leads to the development of diabetic foot ulcers (21,22). In the current study majority of the patients with diabetic foot ulcers were male (62.9%), these results are in line with that reported by other studies (23,24). In the current study, the overall prevalence of patients with diabetic foot ulcers was 11.3%, which is higher than that of the global prevalence of diabetic foot ulcers reported by Zhang et al (5).…”

Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil

“…On the other hand, the few Brazilian studies published show a high prevalence of the Enterobacterales family (51.5%), with S. aureus isolated in 20% and E. faecalis in 17.9% of cases [ 23 ].…”

“…Ciprofloxacin was the agent with the lowest susceptibility to Gram-negatives, most likely because it is an oral antibiotic, which patients must have used before hospitalization and whose previous use induced resistance. In a Brazilian study conducted in Amazonas, 43.5% of the Gram-negative isolated germs were resistant to ciprofloxacin [ 23 ].…”

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“…Enterobacteriaceae. Entre as bactérias Gram-positivas causadoras de infecção estão os germes das famílias Staphylococcaceae e Enterococcaceae (PONTES et al, 2020;JOUHAR et al, 2020).…”