Microbial screening of novel synthesized formazans having amide linkagesΦ

Desai, Krunal G.; Desai, K. R.

doi:10.1002/jhet.5570430440

Cited by 21 publications

(7 citation statements)

References 2 publications

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“…Cyclization of 18 and 19 with polyphosphoric acid at 80°C afforded the thiazole analogues 20 and 21 (63% and 58% yield, respectively). The regioselectivity of the cyclization step may be due to a difference in the electron density at the N1 and N3 positions of 2‐thiopteridine , where the higher electron density of the N3 atom resulted in exclusive cyclization at this position (Scheme ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of New Dipyridylpteridines, Lumazines, and Related Analogues

Abbas

Abu-Mejdad

Atwan

et al. 2016

Journal of Heterocyclic Chem

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Condensation of 4,5‐diaminopyrimidines 2 and 3 with 2,2ʹ‐dipyridil (4) afforded 6,7‐bis(2‐pyridyl)pteridine‐2‐one analogues 5 and 7, respectively. Analogously, 6,7‐bis(2‐pyridyl)luamzine derivatives 13, 15, 17, and 23 were synthesized from reaction of 5,6‐diamino‐2‐thiopyrimidines 13, 14, and 22 with 4, respectively, while condensation of 4,5,6‐triaminopyrimidines (25) or 5,6‐diamino analogue 26 with 4 furnished the 4‐amino‐pteridine analogue 27 and 28, respectively. Thiation of the new pteridines and lumazines afforded the 4‐thio analogues 6, 8, 16, and 24. Treatment of 6 and 8 with methanolic ammonia afforded the 4‐isopterine analogues 9 and 10, respectively. Alkylation of 15 with substituted phenacyl chloride furnished 18 and 19, which cyclized to the thiazolo‐pteridine derivatives 20 and 21, respectively, on treatment with polyphosphoric acid. Alternatively, 27 was prepared from treatment of 24 with methanolic ammonia under drastic conditions. Condensation of 2 or 29 with 2‐oxo‐2‐(thiophen‐2‐yl)acetaldehyde oxime (11) gave the 6‐(2‐thienyl)‐pteridine‐4‐one (12) and 5‐chloro‐2‐(2‐thienyl)pyrido[3,4‐b]pyrazine (31), respectively. All compounds were evaluated for their antiviral activity against the replication of HIV‐1 and HIV‐2 in MT‐4. Some of the synthesized compounds were tested against the bacterial species, Escherichia coli and Staphylococcus aureus, as well as fungal species, Candida tropicalis and Candida albicans.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of New Dipyridylpteridines, Lumazines, and Related Analogues

Abbas

Abu-Mejdad

Atwan

et al. 2016

Journal of Heterocyclic Chem

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“…The regioselectivity of the cyclization step, maybe due to a difference in the electron density at the N1 and N3 positions of 3,4-dihydropyrimidine-2(1 H )-thione. The higher electron density of the N3 atom resulted in exclusive cyclization at this position [46] (Scheme 2). In addition, theoretical computations also reveal that the regioisomers 5-ones resulting from the N3 intramolecular cyclization are more stable and form the major regioisomer [47].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives

et al. 2015

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A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H2SO4. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7-(substituted phenylamino)-5H-thiazolo[3,2-a]pyrimidin-5-ones or sulfonation of cyclized products to sulfonic acid derivatives occurred. The structures of the target compounds were confirmed by IR, 1 H-NMR, 13 C-NMR and HRMS studies. The compounds were evaluated for their preliminary in vitro antibacterial activity against some Gram-positive and Gram-negative bacteria and screened for antitubercular activity against Mycobacterium tuberculosis by the broth dilution assay method. Some compounds showed good antibacterial and antitubercular activities.

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“…Desai [32] prepared heterocyclic formazans (XVII) using diazonium salt of 2-aminobenzothiazole and thiophene-2-aldehyde benzoylhydrazone.…”

Section: XVImentioning

confidence: 99%

Frontiers of Formazans Chemistry: A Review

Kumar¹

2017

WJPR

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Microbial screening of novel synthesized formazans having amide linkagesΦ

Cited by 21 publications

References 2 publications

Synthesis and Biological Evaluation of New Dipyridylpteridines, Lumazines, and Related Analogues

Synthesis and Biological Evaluation of New Dipyridylpteridines, Lumazines, and Related Analogues

Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives

Frontiers of Formazans Chemistry: A Review

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