Microbial profile of neonatal infection in coimbatore

Thomas, Marina; Padmini, B.; Srimathi, G.; Sundararajan, V.; Raju, B Appala

doi:10.1007/bf02752342

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…aureus was the predominantly isolated pathogen in this study; similar findings were seen in several studies [9,10]. Group B Streptococcus, which is a common cause of neonatal sepsis in the west, is infrequent in India and in other tropical countries [11].…”

Section: Discussionsupporting

confidence: 88%

Staphylococcus Aureus- The Predominant Pathogen in the Neonatal ICU of a Tertiary Care Hospital in Amritsar, India

Sharma¹

2013

JCDR

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Background: An early treatment and the appropriate and the rational use of antibiotics would minimize the risk of severe morbidity and mortality in neonatal sepsis, and reduce the emergence of multi-drug resistant organisms in intensive care units. For the success of an early empiric treatment, a periodic review of the cases to assess any changing trends in the infecting organisms and their antimicrobial susceptibility is important. AIM:To study the most commonly encountered bacterial pathogens which caused neonatal sepsis and their sensitivity patterns, so that guidelines could be prepared for a rational antibiotic therapy. Setting and Design:This was a retrospective study which was conducted in the Department of Microbiology and the Neonatal Intensive Care Unit (NICU) at SGRDIMSAR, Amritsar, during June 2011 to June 2012. Methods and Materials:Blood specimens for culture were drawn from 311 newborns who were admitted in an NICU with sepsis. The specimens were inoculated into brain heart infusion broth. Subcultures were performed on days 1, 2, 3, 5, 7 and 10. The isolates were identified by doing standard biochemical tests. The antibiotic resistance patterns of the isolates were studied by the Kirby Bauer disc diffusion technique.Results: A total of 131 organisms were isolated from the 311 blood cultures. These included Staphylococcus aureus (n=68), Coagulase Negative Staphylococcus (CoNS) (n=30), Klebsiella pneumoniae (n=10), Acinetobacter baumannii (n=9), Escherichia coli (n=05), Enterobacter cloacae (n=04), Citrobacter diversus (n=02), Pseudomonas aeruginosa (n=02) and Candida (n=01). Staphylococcus aureus was the main pathogen in both early and late-onset sepsis. On antibiotic sensitivity testing, 57.35% of the Staphylococcus aureus isolates were found to be methicillin resistant. More than 90% gram negative rods were resistant to amikacin. The resistance to the third generation cephalosporins varied between 50-55%. The resistance to ciprofloxacin was quite high; however, most of the isolates were susceptible to levofloxacin. A majority of the isolates were susceptible to piperacillin-tazobactum and imipenem. Conclusion:The present study emphasized the importance of periodic surveys on the microbial flora which was encountered in particular neonatal settings to recognize the trend.

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Section: Discussionsupporting

confidence: 88%

Staphylococcus Aureus- The Predominant Pathogen in the Neonatal ICU of a Tertiary Care Hospital in Amritsar, India

Sharma¹

2013

JCDR

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“…Staphylococcus aureus was the most common organism in our study which was comparable to different studies. 5,11,12 Mortality in our study was 4 % which differed from different studies done in Pakistan, Bangladesh and Nigeria which showed mortalities of 30.9%,20.6% and 20.3% respectively. 13,14,15 This probably resulted from the fact that our neonatal care unit was of level II contrast to the centres of these studies which were level III .…”

Section: Discussioncontrasting

confidence: 97%

Clinical and bacteriological profile of neonates admitted in the neonatal care unit of western regional hospital

Shrestha

Ghimire

Bastola³

et al. 2018

Med. J. Pokhara Acad. Health Sci.

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Background: Neonatal sepsis is leading cause of mortality in neonates. The organism responsible for sepsis differed depending on the site of Neonatal care unit and country. In this study, we aimed to look at cause of sepsis and antibiotic sensitivity. Materials and Methods: Neonates admitted in the neonatal care unit of western regional hospital from 14th August 2012 to 14th July 2014were included in the study. Septic workup was done and culture was sent. Results of culture sensitivity were noted along with the sensitivity pattern. Results: Neonatal sepsis accounted for 38 percent of total admission in the neonatal unit. Staphylococcus aureus was the most common organism isolated which was followed by Escherichia coli (E coli). Staphylococcus aureus isolated was sensitive to Cloxacillin in 97% of cases. There were 5 % mortalities during the study period. Conclusion: Neonatal sepsis was the most common reason for admission and staphylococcus aureus was the most common organism.

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“…The report of the National Neonatal Perinatal database showed Klebsiella as the predominant (29%) pathogen. 19,20 The clinical significance of relatively low virulence isolates, such as CONS and Enterococcus is difficult to ascertain. These organisms can cause true bacteremia or their isolation may represent simple contamination.…”

Section: Discussionmentioning

confidence: 99%

Bacteriological Profile of Blood Culture Positive Sepsis in Newborn at BPKIHS, Dharan Nepal

Kanodia

Yadav

Singh

et al. 2017

J Coll Med Sci-Nepal

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Background & Objectives:Neonatal infections cur r ently cause about 1.6 million deaths annually in developing countries. Sepsis and meningitis is responsible for most of these deaths. This study was undertaken to determine the bacteriological profiles and antibiotic sensitivity patterns of isolates from blood cultures of neonates admitted in a tertiary care hospital in Eastern Nepal. Materials & Methods: A retrospective study was conducted at pediatric department from January, 2014 to December 2014. Total 1009 newborns blood sample with suspected and clinical sepsis were cultured by using standard microbiological technique and antibiotic sensitivity patterns were studied. Results:The positive blood cultur e was 32.4% (327/1009). Gr am positive bacteria were more common 231(71%) than gram negative bacteria 96(29%). Staphylococcus aureus 174 (53.2%) and acinetobacter 46(14.1%) were the commonest isolates in blood culture. Most of the organisms showed sensitivity with aminoglycosides (gentamicin and amikacin) and third generation cephalosporins. Conclusion: Staphylococcus aureus, Acinetobacter and Klebsiella species remain the principal organisms causing neonatal sepsis and antibiotics like amino glycosides should be first choice of drugs.

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Microbial profile of neonatal infection in coimbatore

Cited by 15 publications

References 22 publications

Staphylococcus Aureus- The Predominant Pathogen in the Neonatal ICU of a Tertiary Care Hospital in Amritsar, India

Staphylococcus Aureus- The Predominant Pathogen in the Neonatal ICU of a Tertiary Care Hospital in Amritsar, India

Clinical and bacteriological profile of neonates admitted in the neonatal care unit of western regional hospital

Bacteriological Profile of Blood Culture Positive Sepsis in Newborn at BPKIHS, Dharan Nepal

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