Microbial Production of Chiral Hydroxy Esters and Their Analogs: Biocatalytic Reduction of Carbonyl Compounds by Actinobacteria, <i>Agromyces</i> and <i>Gordonia</i> Strains

Stereoselective Reduction of Bisdemethoxycurcumin to (R)-Hexahydrobisdemethoxycurcumin by Cultured Morus bombycis Plant Cells

“…Also, it has been the subject of increasing attention, because stereoselective enzymatic reduction is useful for the preparation of chiral building blocks in the synthesis of optically active drugs. [2][3][4][5] In addition, the reduction of bioactive compounds can enhance their physicochemical stability, and improve their bio-and pharmacological properties. We recently reported that cultured Marchantis polymorpha cells reduced curcumin [1,7-bis(4 -hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione] to tetrahydro-curcumin.…”