“…Dysregulation of serotonergic signaling pathways has been previously implicated in many psychiatric and neurological conditions such as pain, sleep problems, appetite and mood variations ( Athar, 2010 ), and disorders like depression, anxiety, schizophrenia, attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), migraine headache, autism spectrum disorders (ASD; Pourhamzeh et al, 2021 ), bipolar disorder (BP) and addictive behavior ( Lin et al, 2014 ). Serotonin depletion has also been implicated in neurodegenerative diseases, such as Alzheimer’s disease, as serotonin levels decrease with age and neuroinflammation processes have been associated with reduction of serotonin precursors in the CNS ( Danilovich et al, 2021 ). Additionally, lower levels of serotonin have been detected in fibromyalgia patients, where this imbalance has also been associated with other key symptoms such as fatigue and cognitive deficits ( Welsch et al, 2018 ).…”