Microbial lectins

Kotecha, Hetika; Poduval, Preethi B.

doi:10.1016/b978-0-12-817497-5.00009-4

Advances in Biological Science Research 2019

DOI: 10.1016/b978-0-12-817497-5.00009-4

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Microbial lectins

Hetika Kotecha

Preethi B. Poduval

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Cited by 3 publications

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“…These ubiquitous proteins have the ability to interact with glycans on the cell surfaces thus aiding in agglutination of different cell types. This property of lectins has been exploited in biotechnological applications such as glycoconjugate-based cell physiology and pathology [21], in bio-flocculation, as drug targeting agents and probiotics [22]. Various types of lectins isolated from Bauhinia genus plants from the family Leguminosae have been reported to possess medicinal properties like antitumor, use as hemagglutination and chemotaxonomic markers.…”

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confidence: 99%

Leveraging Lucrative Lectins: An Explorative Review of the Biomedical Properties of Lectins

2024

IJFMR

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Nature is a bountiful supplier of resources for all living beings. Moreover, nature has also been the recourse for numerous global problems including disorders and ailments. Natural product chemistry is the most sought-after field, probing into biological and industrial applications of different natural compounds isolated from sources like plants and microorganisms. Lectins, dating way back as to almost 130 years ago, have had a long standing in history in lieu of their numerous biomedical benefits. Marking the modern age of lectins in 1972, ‘lectinology’ came to be known as a potential field of research probing into various medical properties of lectins from different plants. These proteins display a plethora of benefits including wound-healing, anticoagulating, anti-nociceptive, antimicrobial, antiviral and immunomodulatory properties. The present review explores these lucrative properties of lectins and also discusses the current status of lectin-based antiviral therapeutics that hold immense potential for effective treatment of fastidious pathogens

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confidence: 99%

Leveraging Lucrative Lectins: An Explorative Review of the Biomedical Properties of Lectins

2024

IJFMR

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Anti-coronaviral Activity of Plant and Seaweed Secondary Metabolites: A Review

Ülger

Yılmaz

Çakiroğlu

et al. 2022

COVID

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Background: The Coronavirus Disease 2019 (COVID-19), one of the greatest challenges facing humanity, continues to affect millions of people worldwide. Vaccines approved and authorized for use are effective against COVID-19, but viral variants of concern may emerge in the near future. The discovery of novel antiviral agents will help humanity overcome COVID-19 and aid in any future viral pandemics. Objective: This review aimed to evaluate evidence from the plant- and seaweed-derived secondary compound-based interventions for viral diseases caused by coronaviruses. Methods: A comprehensive search of several databases including Cochrane Library, Web of Science and PubMed were conducted to identify available studies evaluating the outcomes of plant- and seaweed secondary metabolites in viral diseases such as Severe Acute Respiratory Syndrome, Middle East Respiratory Syndrome and COVID-19. Results: The volume of existing reports is irrefutable evidence that some plant- and seaweed-derived secondary compounds (e.g., mannose-specific lectins, griffithsin, cyanovirin-N, gallate, curcumin, luteolin, quercetin and betulinic acid) possess a potential antiviral ability against coronaviruses, including SARS-CoV-2. Conclusion: Plant and seaweed secondary metabolites with antiviral activity show their activity in different metabolic pathways. Besides reducing and preventing the metabolic damage caused by proinflammatory cytokines and oxidative stress, several plant and seaweed secondary metabolites can also be effective in improving some clinical indexes specific to COVID-19. Despite their effectiveness in preclinical studies, plant and seaweed-derived secondary compounds need more pharmacokinetic studies and safety measures concerning their mitogenic and allergenic properties.

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Algal and Cyanobacterial Lectins and Their Antimicrobial Properties

et al. 2021

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Lectins are proteins with a remarkably high affinity and specificity for carbohydrates. Many organisms naturally produce them, including animals, plants, fungi, protists, bacteria, archaea, and viruses. The present report focuses on lectins produced by marine or freshwater organisms, in particular algae and cyanobacteria. We explore their structure, function, classification, and antimicrobial properties. Furthermore, we look at the expression of lectins in heterologous systems and the current research on the preclinical and clinical evaluation of these fascinating molecules. The further development of these molecules might positively impact human health, particularly the prevention or treatment of diseases caused by pathogens such as human immunodeficiency virus, influenza, and severe acute respiratory coronaviruses, among others.

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Microbial lectins

Cited by 3 publications

References 52 publications

Leveraging Lucrative Lectins: An Explorative Review of the Biomedical Properties of Lectins

Leveraging Lucrative Lectins: An Explorative Review of the Biomedical Properties of Lectins

Anti-coronaviral Activity of Plant and Seaweed Secondary Metabolites: A Review

Algal and Cyanobacterial Lectins and Their Antimicrobial Properties

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