Microbial communities associated with anaerobic degradation of polybrominated diphenyl ethers in river sediment

Yang, Chu‐Wen; Huang, Haijun; Chang, Bea‐Ven

doi:10.1016/j.jmii.2014.12.009

Cited by 18 publications

(1 citation statement)

References 19 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…anaerobic degradation of BDE-209 and BDE-28 in the sediment (Robrock et al, 2008;Yang et al, 2017). Another study also demonstrated a positive relationship between bacteria (Actinobacteria and Erysipelotrichia) and biodegradation of lesser-brominated PBDE congeners, tri-BDE, and tetra-BDE (Xu et al, 2012).…”

Section: Discussionmentioning

confidence: 87%

PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice

Dempsey

Wang

et al. 2018

Drug Metab Dispos

View full text Add to dashboard Cite

Polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants with well characterized toxicities in host organs. Gut microbiome is increasingly recognized as an important regulator of xenobiotic biotransformation; however, little is known about its interactions with PBDEs. Primary bile acids (BAs) are metabolized by the gut microbiome into more lipophilic secondary BAs that may be absorbed and interact with certain host receptors. The goal of this study was to test our hypothesis that PBDEs cause dysbiosis and aberrant regulation of BA homeostasis. Nine-week-old male C57BL/6 conventional (CV) and germ-free (GF) mice were orally gavaged with corn oil (10 mg/kg), BDE-47 (100 mol/kg), or BDE-99 (100mol/kg) once daily for 4 days ( = 3-5/group). Gut microbiome was characterized using 16S rRNA sequencing of the large intestinal content in CV mice. Both BDE-47 and BDE-99 profoundly decreased the alpha diversity of gut microbiome and differentially regulated 45 bacterial species. Both PBDE congeners increased and Erysipelotrichaceae spp., which have been reported to have anti-inflammatory and antiobesity functions. Targeted metabolomics of 56 BAs was conducted in serum, liver, and small and large intestinal content of CV and GF mice. BDE-99 increased many unconjugated BAs in multiple biocompartments in a gut microbiota-dependent manner. This correlated with an increase in microbial 7-dehydroxylation enzymes for secondary BA synthesis and increased expression of host intestinal transporters for BA absorption. Targeted proteomics showed that PBDEs downregulated host BA-synthesizing enzymes and transporters in livers of CV but not GF mice. In conclusion, there is a novel interaction between PBDEs and the endogenous BA-signaling through modification of the "gut-liver axis".

show abstract

Section: Discussionmentioning

confidence: 87%

PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice

Dempsey

Wang

et al. 2018

Drug Metab Dispos

View full text Add to dashboard Cite

show abstract

H alalkalicoccus

Ventosa

Sánchez‐Porro

2017

Bergey's Manual of Systematics of Archaea and Bacteria

View full text Add to dashboard Cite

Hal.al.ka.li.coc'cus. Gr. n. hals, halos salt; N.L. n. alkali alkali; N.L. masc. n. coccus from Gr. masc. n. kokkos berry; N.L. masc. n. Halalkalicoccus coccus existing in salted and alkaline environment. Euryarchaeota / Halobacteria / Halobacteriales / Halobacteriaceae / Halalkalicoccus The genus Halalkalicoccus is classified within the family Halobacteriaceae and the order Halobacteriales , in the class Halobacteria . The cells are cocci and stain Gram‐negative or are Gram‐variable. Colonies are pink‐, orange‐, or red‐pigmented. Strictly aerobic. They are extreme halophiles, growing in media containing 1.0–5.9 M NaCl, with optimal growth at 2.6–4.3 M NaCl and neutrophilic (optimal growth at pH 6.5–7.5) or alkaliphilic (optimal growth at pH 9.5–10.0). Cells do not lyse in distilled water. Polar lipids include phosphatidylglycerol and phosphatidylglycerol phosphate methyl ester. Phosphatidylglycerol sulfate, sulfated mannosyl glucosyl diether, and glycolipids may be present. Isoprenoid quinones are MK‐8 and MK‐8(H 2 ). Currently, the genus includes three species: Halalkalicoccus tibetensis (type species of the genus), Hac. jeotgali , and Hac. paucihalophilus . The strains of these species were isolated from a soda lake, from shrimp jeotgal, a traditional Korean fermented seafood, and from a saline soil. DNA G + C content (mol%) : 60.4–63.2. Type species : Halalkalicoccus tibetensis Xue, Fan, Ventosa, Grant, Jones, Cowan and Ma 2005, 2504 VP .

show abstract