Microbial Barrier Property and Blood Compatibility Studies of Electrospun Poly-ƹ-Caprolactone/ Zinc Oxide Nanocomposite Scaffolds

Augustine, Robin; Kalarikkal, Nandakumar; Thomas, Sabu

doi:10.17516/1997-1389-0025

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…Our earlier studies using other PCL-based scaffolds also showed a similar trend. 45 Cell adhesion and viability are the key features that govern the fate of a successful tissue engineering platform. 46 Because the developed scaffolds are intended for in situ tissue engineering applications, these in turn rely on the ability of the scaffold itself to provide required cues for cell adhesion, migration and proliferation.…”

Section: ■ Discussionmentioning

confidence: 99%

Nanoceria Can Act as the Cues for Angiogenesis in Tissue-Engineering Scaffolds: Toward Next-Generation in Situ Tissue Engineering

Augustine

Dalvi

Dan

et al. 2018

ACS Biomater. Sci. Eng.

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Next-generation tissue engineering exploits the body’s own regenerative capacity by providing an optimal niche via a scaffold for the migration and subsequent proliferation of endogenous cells to the site of injury, enhancing regeneration and healing and bypassing laborious in vitro cell-culturing procedures. Such systems are also required to have a sufficient angiogenic capacity for the subsequent patency of implanted scaffolds. The exploitation of redox properties of nanodimensional ceria (nCeO2) in in situ tissue engineering to promote cell adhesion and angiogenesis is poorly investigated. As a novel strategy, electrospun polycaprolactone based tissue-engineering scaffolds loaded with nCeO2 were developed and evaluated for morphological and physicomechanical features. In addition, in vitro and in vivo studies were performed to show the ability of nCeO2-containing scaffolds to enhance cell adhesion and angiogenesis. These studies confirmed that nCeO2-containing scaffolds supported cell adhesion and angiogenesis better than bare scaffolds. Gene-expression studies had shown that angiogenesis-related factors such as HIF1α and VEGF were up-regulated. Overall results show that incorporation of nCeO2 plays a key role in scaffolds for the enhancement of angiogenesis, cell adhesion, and cell proliferation and can produce a successful outcome in in situ tissue engineering.

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Section: ■ Discussionmentioning

confidence: 99%

Nanoceria Can Act as the Cues for Angiogenesis in Tissue-Engineering Scaffolds: Toward Next-Generation in Situ Tissue Engineering

Augustine

Dalvi

Dan

et al. 2018

ACS Biomater. Sci. Eng.

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“…In addition, they should be of small size in order to protect from microbials. 102 The desirable skin equivalent should have a pore size between 200 and 400 μm. 103 Furthermore, they should be biodegradable and should maintain their 3D structure for minimum 3 weeks to enable the ingrowth of fibroblasts and blood vessels and to proliferate epithelial cells.…”

Section: The Required Properties Of Bioprinted Skinmentioning

confidence: 99%

3D Bioprinting in Skin Related Research: Recent Achievements and Application Perspectives

et al. 2021

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In recent years, significant progress has been observed in the field of skin bioprinting, which has a huge potential to revolutionize the way of treatment in injury and surgery. Furthermore, it may be considered as an appropriate platform to perform the assessment and screening of cosmetic and pharmaceutical formulations. Therefore, the objective of this paper was to review the latest advances in 3D bioprinting dedicated to skin applications. In order to explain the boundaries of this technology, the architecture and functions of the native skin were briefly described. The principles of bioprinting methods were outlined along with a detailed description of key elements that are required to fabricate the skin equivalents. Next, the overview of recent progress in 3D bioprinting studies was presented. The article also highlighted the potential applications of bioengineered skin substituents in various fields including regenerative medicine, modeling of diseases, and cosmetics/drugs testing. The advantages, limitations, and future directions of this technology were also discussed.

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“…The porous structure of constructs will provide good aeration for the cells and does not lead to wound dehydration. At the same time, the pores need to be small so that the skin substitute will protect the wound from microbial invasion (Augustine et al 2017b ).…”

Section: Desirable Properties Of Bioprinted Skinmentioning

confidence: 99%

Skin bioprinting: a novel approach for creating artificial skin from synthetic and natural building blocks

2018

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Significant progress has been made over the past few decades in the development of in vitro-engineered substitutes that mimic human skin, either as grafts for the replacement of lost skin, or for the establishment of in vitro human skin models. Tissue engineering has been developing as a novel strategy by employing the recent advances in various fields such as polymer engineering, bioengineering, stem cell research and nanomedicine. Recently, an advancement of 3D printing technology referred as bioprinting was exploited to make cell loaded scaffolds to produce constructs which are more matching with the native tissue. Bioprinting facilitates the simultaneous and highly specific deposition of multiple types of skin cells and biomaterials, a process that is lacking in conventional skin tissue-engineering approaches. Bioprinted skin substitutes or equivalents containing dermal and epidermal components offer a promising approach in skin bioengineering. Various materials including synthetic and natural biopolymers and cells with or without signalling molecules like growth factors are being utilized to produce functional skin constructs. This technology emerging as a novel strategy to overcome the current bottle-necks in skin tissue engineering such as poor vascularization, absence of hair follicles and sweat glands in the construct.

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Microbial Barrier Property and Blood Compatibility Studies of Electrospun Poly-ƹ-Caprolactone/ Zinc Oxide Nanocomposite Scaffolds

Cited by 5 publications

References 15 publications

Nanoceria Can Act as the Cues for Angiogenesis in Tissue-Engineering Scaffolds: Toward Next-Generation in Situ Tissue Engineering

Nanoceria Can Act as the Cues for Angiogenesis in Tissue-Engineering Scaffolds: Toward Next-Generation in Situ Tissue Engineering

3D Bioprinting in Skin Related Research: Recent Achievements and Application Perspectives

Skin bioprinting: a novel approach for creating artificial skin from synthetic and natural building blocks

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