Microbial activity and swelling behavior of chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer interface containing amoxicillin for wound dressing applications

doi:10.33263/briac95.368373

Cited by 18 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the process of drug discovery and development must be optimized in order to ensure optimal pharmacokinetics, absorption, distribution, metabolism, excretion, toxicity, and therapeutic effect duration [102]. In the context of infectious diseases, the life and bioavailability of antimicrobial drugs must be enhanced, while the administered dose must be reduced [103,104].…”

Section: Antimicrobial Applications Of Polymeric Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

View full text Add to dashboard Cite

Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

show abstract

Section: Antimicrobial Applications Of Polymeric Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The development of a suitable material for covering the wound and further prevent infection is a long-established requirement [82]. Researchers have been using different natural polymers, such as alginate [81,[83][84][85], chitosan [81,[86][87][88], collagen [89,90], dextran [91,92], hyaluronan [2,93], xanthan [94,95], konjac [95], and gelatin [96] for the production of hydrogels. Their wide application in wound dressing fabrication is based on their similitude to the extracellular matrix (ECM), which further improves acceptance by biological systems through the inhibition of the immunological reactions frequently observed for synthetic polymers [81,97].…”

Section: Inert Hydrogels For Treatment Of Burn Wound Dressingsmentioning

confidence: 99%

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

2020

View full text Add to dashboard Cite

Globally, the fourth most prevalent devastating form of trauma are burn injuries. Ideal burn wound dressings are fundamental to facilitate the wound healing process and decrease pain in lower time intervals. Conventional dry dressing treatments, such as those using absorbent gauze and/or absorbent cotton, possess limited therapeutic effects and require repeated dressing changes, which further aggravate patients’ suffering. Contrariwise, hydrogels represent a promising alternative to improve healing by assuring a moisture balance at the burn site. Most studies consider hydrogels as ideal candidate materials for the synthesis of wound dressings because they exhibit a three-dimensional (3D) structure, which mimics the natural extracellular matrix (ECM) of skin in regard to the high-water amount, which assures a moist environment to the wound. There is a wide variety of polymers that have been used, either alone or blended, for the fabrication of hydrogels designed for biomedical applications focusing on treating burn injuries. The aim of this paper is to provide an up-to-date overview of hydrogels applied in burn wound dressings.

show abstract

“…The phases involved in the wound healing process are hemostasis, inflammation, proliferation, and remodeling (Figure 1) [1,2]. Wound healing represents a very complex process that requires a long time to be complete [3], as the remodeling phase to form the proper environment can last from 21 days to 1 year [4,5].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for Wound Dressings: An Up-to-Date Overview

2020

View full text Add to dashboard Cite

As wound healing continues to be a challenge for the medical field, wound management has become an essential factor for healthcare systems. Nanotechnology is a domain that could provide different new approaches concerning regenerative medicine. It is worth mentioning the importance of nanoparticles, which, when embedded in biomaterials, can induce specific properties that make them of interest in applications as materials for wound dressings. In the last years, nano research has taken steps to develop molecular engineering strategies for different self-assembling biocompatible nanoparticles. It is well-known that nanomaterials can improve burn treatment and also the delayed wound healing process. In this review, the first-line of bioactive nanomaterials-based dressing categories frequently applied in clinical practice, including semi-permeable films, semipermeable foam dressings, hydrogel dressings, hydrocolloid dressings, alginate dressings, non-adherent contact layer dressings, and multilayer dressings will be discussed. Additionally, this review will highlight the lack of high-quality evidence and the necessity for future advanced trials because current wound healing therapies generally fail to provide an excellent clinical outcome, either structurally or functionally. The use of nanomaterials in wound management represents a unique tool that can be specifically designed to closely reflect the underlying physiological processes in tissue repair.

show abstract

Microbial activity and swelling behavior of chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer interface containing amoxicillin for wound dressing applications

Cited by 18 publications

References 20 publications

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

Nanomaterials for Wound Dressings: An Up-to-Date Overview

Contact Info

Product

Resources

About