Microarray Studies in <i>Bacillus subtilis</i>

Kocabaş, Pınar; Çalı́k, Pınar; Çalık, Güzide; Özdamar, Tunçer H.

doi:10.1002/biot.200800330

Cited by 6 publications

(1 citation statement)

References 138 publications

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“…Over the last few years, functional genomics approaches, including transcriptomics, have been increasingly used to obtain global gene expression profiles, thereby providing a comprehensive view of microorganism physiology [12,13]. Although the genome sequences of several L. garvieae strains from different origins have been published recently [14-21], such global approaches have not yet been used to study the transcriptome of this pathogen.…”

Section: Introductionmentioning

confidence: 99%

Global Transcriptome Analysis of Lactococcus garvieae Strains in Response to Temperature

et al. 2013

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Lactococcus garvieae is an important fish and an opportunistic human pathogen. The genomic sequences of several L. garvieae strains have been recently published, opening the possibility of global studies on the biology of this pathogen. In this study, a whole genome DNA microarray of two strains of L. garvieae was designed and validated. This DNA microarray was used to investigate the effects of growth temperature (18°C and 37°C) on the transcriptome of two clinical strains of L. garvieae that were isolated from fish (Lg8831) and from a human case of septicemia (Lg21881). The transcriptome profiles evidenced a strain-specific response to temperature, which was more evident at 18°C. Among the most significant findings, Lg8831 was found to up-regulate at 18°C several genes encoding different cold-shock and cold-induced proteins involved in an efficient adaptive response of this strain to low-temperature conditions. Another relevant result was the description, for the first time, of respiratory metabolism in L. garvieae, whose gene expression regulation was temperature-dependent in Lg21881. This study provides new insights about how environmental factors such as temperature can affect L. garvieae gene expression. These data could improve our understanding of the regulatory networks and adaptive biology of this important pathogen.

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Section: Introductionmentioning

confidence: 99%

Global Transcriptome Analysis of Lactococcus garvieae Strains in Response to Temperature

et al. 2013

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Biotechnology in Turkey: An overview

Özdamar

2009

Biotechnology Journal

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The term biotechnology first appeared in the programs of the Scientific and Technological Research Council of Turkey (TUBITAK) in 1982. The State Planning Organization (SPO) in 1988 defined biotechnology and the scientific fields. Moreover, it put forward an institutional framework and suggested priority areas for research and development. Turkey has been researching and investing in biotechnology for almost four decades. This review covers the development of science and technology policy with its history, consensus and consequences, bio-industries in Turkey, and research activities in biotechnology at Turkish Universities. Details are provided by the research groups in response to a common request for information on their activities and major publications in the field. The information provided has been grouped under thematic topics within the broad theme of biotechnology, and summarized within these topics. Although many aspects of biotechnological research are being pursued in Turkey, it appears that the most common research activities of the field are in fermentation processes, environmental biotechnology, and biomedical engineering.

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