Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells

Lindenmeyer, Maja T.; Kern, Claudia; Sparna, Titus; Donauer, Johannes; Wilpert, Jochen; Schwager, Joseph; Porath, Debora; Kreutz, Clemens; Timmer, Jens; Merfort, Irmgard

doi:10.1016/j.lfs.2007.01.036

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…Luteolin inhibited the in vivo TNF-a production, reduced the ear edema (induced by PMA and oxazolone) and ICAM-1 expression in LPS-treated mice. 22 Luteolin, kaempferol (97), and quercetin exhibited a significant inhibitory effect on MMP-9 and MMP-2. 137 Luteolin also inhibited the protein tyrosine phosphorylation, NF-kB-mediated gene expression, and proinflammatory cytokine production in murine macrophages.…”

Section: Polyphenolics a Flavonoidsmentioning

confidence: 95%

“…96 Parthenolide showed change in the gene expression profile in TNF-a stimulated human 293 cells using a cDNA microarray analysis. 97 Costunolide (49) and parthenolide, isolated from Magnolia grandiflora, inhibited NO production by down-regulating the iNOS expression, which in turn through the inhibition of IkB phosphorylation and degradation, essential for the NF-kB activation. The inhibitory effects of costunolide were higher than that of parthenolide.…”

Section: Terpenoidsmentioning

confidence: 99%

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Recent developments in anti‐inflammatory natural products

Gautam

Jachak

2009

Medicinal Research Reviews

395

230

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Many of the inflammatory diseases are becoming common in aging society throughout the world. The clinically used anti-inflammatory drugs suffer from the disadvantage of side effects and high cost of treatment (in case of biologics). Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Since ancient times traditional medicines and phytopharmaceuticals are being used for the treatment of inflammatory and other disorders. The present review article describes anti-inflammatory natural products derived from plants and marine sources reported during last decade. The compounds described belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds. The attempt is also being made to enumerate the possible leads, e.g. curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid, and oleanolic acid, for further development with the help of structure-activity relationship (SAR) studies and their current status. In addition SAR studies carried out on the anti-inflammatory activity of flavonoid compounds and clinical studies performed on anti-inflammatory natural products are also discussed.

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Section: Polyphenolics a Flavonoidsmentioning

confidence: 95%

Section: Terpenoidsmentioning

confidence: 99%

Recent developments in anti‐inflammatory natural products

Gautam

Jachak

2009

Medicinal Research Reviews

395

230

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“…If we extend this reasoning to drug effects, an interesting picture emerges. Consider that drug activity changes some conditions in the body, and these conditions are reflected in changes of gene expression [51]. If regulation of expression and DNA methylation are indeed linked, a change in the DNA methylation pattern may be observed, not only for drugs that inhibit methylation-related functions [52], but also for any drug that is physiologically active.…”

Section: Dna Methylation For Treatment Monitoring Prediction Of Respmentioning

confidence: 99%

DNA methylation as a universal biomarker

Levenson

2010

Expert Review of Molecular Diagnostics

136

108

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Cell-free circulating DNA carries not only tumor-specific changes in its sequence but also distinctive epigenetic marks, namely DNA methylation, in certain GC-rich fragments. These fragments are usually located within the promoters and first exons of many genes, comprising CpG islands. Analysis of DNA methylation using cell-free circulating DNA can facilitate development of very accurate biomarkers for detection, diagnosis, prediction of response to therapy and prognosis of outcomes. Recent data suggest that benign and inflammatory diseases have very specific methylation patterns within cell-free circulating DNA, which are different from the pattern of a malignant tumor of the same organ. In addition, specific methylation patterns have been detected for cancers of different organs, so a differential diagnosis of site-specific cancer appears feasible. Currently, cancer-related applications dominate the field, although methylation-based biomarkers may also be possible for other diseases, including neurodegenerative and psychiatric disorders.

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