Microarray Analysis of NF-κB Signaling Pathways in PBMC of Mice Infected by Trichinella Spiralis

Abstract

The NF-kappaΒ pathway gene expression profiles were compared between 10, 20 and 39 days after Trichinella spiralis experimental infection in BALB/c mice. Out of 128 genes, 19 (14.8%) genes were present in non-infected and post-infected mice. The expression of 7 (36.8%) genes was downregulated 10 and 20 days post-infection while 3 (15.8%) genes were upregulated 39 days post-infection. The present study lists the candidate genes of the NF-kappaB signaling pathway that were commonly and differentially expressed between the specific points of T. spiralis infection, thus suggesting that these genes need to be further investigated to reveal the mechanism of the T. spiralis modulation of the NF-kappaB signaling pathways.

Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-κB and NOS/NO signaling pathways

“…Symeonidou et al investigated 128 genes' expression profiles from NF-κB signaling pathway in Trichinella spiralis-infected mice via microarray analysis and found that various gene expressions were affected between the specific points of Trichinella spiralis infection (Symeonidou et al 2010). Similarly, the present results revealed that Trichinella spiralis infection activated NF-κB and induction of HSP70 significantly inhibited NF-κB activation, which is similar with the role of PDTC, an NF-κB inhibitor.…”