Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles

Karnik, Pratima; Shah, Selam; Dvorkin-Wininger, Yevgeniya; Oshtory, Shaheen; Mirmirani, Paradi

doi:10.1016/j.jdermsci.2013.06.017

Cited by 29 publications

(26 citation statements)

References 8 publications

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“…Ultimately, a study comparing androgenetic alopecia and senescent alopecia using microarray analysis demonstrated significant differences in the gene expression patterns, further corroborating that they in fact represent different entities: In androgenetic alopecia, genes required for anagen onset, epithelial signal to dermal papilla, hair shaft differentiation and anagen maintenance were downregulated, and genes for catagen and telogen induction and maintenance were upregulated; whereas in senescent alopecia, genes involved in epithelial signal to dermal papilla, actin cytoskeleton and mitochondrial function were down‐regulated, while oxidative stress and inflammatory response genes were up‐regulated.…”

Section: Pre‐emerging Factors: Oxidative Stress In Ageing Of Hairmentioning

confidence: 89%

The impact of oxidative stress on hair

Trüeb¹

2015

Intern J of Cosmetic Sci

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Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to detoxify the reactive intermediates or to repair the resulting damage. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage lipids, proteins, and DNA. They are generated by a multitude of endogenous and environmental challenges, while the body possesses endogenous defense mechanisms. With age, production of free radicals increases, while the endogenous defense mechanisms decrease. This imbalance leads to progressive damage of cellular structures, presumably resulting in the aging phenotype. While the role of oxidative stress has been widely discussed in skin aging, little focus has been placed on its impact on hair condition. Moreover, most literature on age-related hair changes focuses on alopecia, but it is equally important that the hair fibers that emerge from the scalp exhibit significant agerelated changes that have equal impact on the overall cosmetic properties of hair. Sources of oxidative stress with impact on the pre-emerging fiber include: oxidative metabolism, smoking, UVR, and inflammation from microbial, pollutant, or irritant origins. Sources of oxidative stress with impact on the post-emerging fiber include: UVR (enhanced by copper), chemical insults, and oxidized scalp lipids. The role of the dermatologist is recognition and treatment of pre-and post-emerging factors for lifetime scalp and hair health.R esum e Le stress oxydatif refl ete un d es equilibre entre la manifestation syst emique des d eriv es r eactifs de l'oxyg ene et la capacit e d'un syst eme biologique a d etoxifier les interm ediaires r eactifs ou a r eparer les dommages en r esultant. Les d eriv es r eactifs de l'oxyg ene ou « radicaux libres » sont des mol ecules hautement r eactives qui peuvent endommager directement les lipides, les prot eines et l'ADN. Ils sont g en er es par une multitude de d efis environnementaux et endog enes, tandis que le corps poss ede des m ecanismes de d efense endog enes. Avec l'âge, la production de radicaux libres augmente, pendant que les m ecanismes de d efense endog enes diminuent. Ce d es equilibre conduit a la d et erioration progressive des structures cellulaires, r esultant vraisemblablement dans le ph enotype de vieillissement. Bien que le rôle du stress oxydatif ait et e largement discut e dans le contexte du vieillissement de la peau, peu d'attention a et e accord ee a son impact sur l' etat des cheveux. En outre, la plupart des etudes sur les changements des cheveux li ee a l'âge se concentre sur l'alop ecie, mais il est tout aussi important que les fibres capillaires qui emergent du cuir chevelu pr esentent des changements importants li es a l'âge qui ont aussi un impact sur les propri et es cosm etiques des cheveux. Les sources de stress oxydatif avec un impact sur la fibre capillaire pr e-emergence comprennent: le m etabolisme oxydatif, le tabagisme, les rayons UV, l'inflammation d'origine microb...

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Section: Pre‐emerging Factors: Oxidative Stress In Ageing Of Hairmentioning

confidence: 89%

The impact of oxidative stress on hair

Trüeb¹

2015

Intern J of Cosmetic Sci

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“…In androgenetic alopecia, hormonal signals lead to changes in genes regulating hair follicle size and cycling and there is a gradual diminution of the hair follicle. In senescent alopecia, which has its onset after the age of 60, follicular dropout and thinning occur as a results of apoptosis and oxidative stress responses and may be a manifestation of systemic aging processes [27]. Extrinsic factors such as hair processing, ultraviolet light, and smoking also have a negative effect on the hair.…”

Section: Discussionmentioning

confidence: 99%

“…Microarray comparison of age-matched subjects with androgenetic alopecia, senescent alopecia and normal controls without hair loss has shown that androgenetic alopecia is associated with altered expression of genes known to be required for hair follicle cycling. In stark contrast, the transcriptional profile of senescent alopecia reveals changes in the complex phenomenon of alternative splicing, oxidative stress response, and apoptosis, which are characteristic of aging tissues [27]. This difference in mechanism has significant implications in terms of treatment of hair loss at different ages.…”

Section: Non-androgen Mediated Hair Loss: Senescent Alopeciamentioning

confidence: 99%

“…Although androgenetic alopecia and senescent alopecia share many clinical and histologic features, the mechanisms by which follicular downsizing and miniaturization occur has recently been shown to be distinct [27]. Microarray comparison of age-matched subjects with androgenetic alopecia, senescent alopecia and normal controls without hair loss has shown that androgenetic alopecia is associated with altered expression of genes known to be required for hair follicle cycling.…”

Section: Non-androgen Mediated Hair Loss: Senescent Alopeciamentioning

confidence: 99%

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Age-related hair changes in men: Mechanisms and management of alopecia and graying

Mirmirani

2015

Maturitas

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“…Supporting the existence of senile alopecia, some have found different gene expression profiles in senile alopecia and androgenetic alopecia . While androgenetic alopecia underexpresses genes related to the development, morphology, cycling, and homeostasis of the hair follicle, senile alopecia expresses genes related to alternative splicing, oxidative stress response, and apoptosis …”

Section: Is Senile Alopecia Different From Androgenetic Alopecia?mentioning

confidence: 99%

Histopathology of aging of the hair follicle

Fernández-Flores

Saeb‐Lima

2019

J Cutan Pathol

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Hair follicles experience several changes with aging, the most noticeable of which is graying of the hair shaft due to loss of melanin. Additional changes in the diameter and length of the hair have contributed to the concept of senescent alopecia, which is different from androgenetic alopecia according to most. Graying happens in most individuals, although in different grades and starting at different ages. It is related to a decrease in the number and activity of the melanocytes of the hair bulb, which eventually completely disappear from the bulb of the white hair. Residual non-active melanocytes remain in the outer root sheath and in the bulge, which allows for repigmentation of the hair under certain stimuli or conditions.

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Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles

Cited by 29 publications

References 8 publications

The impact of oxidative stress on hair

The impact of oxidative stress on hair

Age-related hair changes in men: Mechanisms and management of alopecia and graying

Histopathology of aging of the hair follicle

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