Histopathology of aging of the hair follicle

Fernández-Flores, Ángel; Saeb‐Lima, Marcela

doi:10.1111/cup.13467

Cited by 36 publications

(36 citation statements)

References 83 publications

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“…Ageing is an inevitable biological event and is usually accompanied by decreased function, including diminished self-renewal ability of stem cells [ 80 ]. This process involves various systems of the human body (e.g., haematopoietic system, skin, brain) and may have clinical consequences, such as defective immune responses, Alzheimer’s disease and hair loss [ 81 – 83 ]. The molecular mechanism of ageing remains unclear.…”

Section: Paneth Cells Affect Intestinal Stem Cells In Ageingmentioning

confidence: 99%

Plasticity of Paneth cells and their ability to regulate intestinal stem cells

Mei

2020

Stem Cell Res Ther

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Paneth cells (PCs) are located at the bottom of small intestinal crypts and play an important role in maintaining the stability of the intestinal tract. Previous studies reported on how PCs shape the intestinal microbiota or the response to the immune system. Recent studies have determined that PCs play an important role in the regulation of the homeostasis of intestinal epithelial cells. PCs can regulate the function and homeostasis of intestinal stem cells through several mechanisms. On the one hand, under pathological conditions, PCs can be dedifferentiated into stem cells to promote the repair of intestinal tissues. On the other hand, PCs can regulate stem cell proliferation by secreting a variety of hormones (such as wnt3a) or metabolic intermediates. In addition, we summarise key signalling pathways that affect PC differentiation and mutual effect with intestinal stem cells. In this review, we introduce the diverse functions of PCs in the intestine.

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Section: Paneth Cells Affect Intestinal Stem Cells In Ageingmentioning

confidence: 99%

Plasticity of Paneth cells and their ability to regulate intestinal stem cells

Mei

2020

Stem Cell Res Ther

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“…Within the epidermis the turnover of keratinocytes is reduced resulting in a thinning of the epidermis and a reduced capacity to rapidly restore the skin barrier after barrier breaks. As to the skin appendages, hair becomes thinner and on the scalp terminal hair follicles are gradually miniaturized (Fernandez-Flores et al, 2019). Most obvious, the natural hair color is lost due to a reduced transfer of pigment from follicular melanocytes to hair keratinocytes and air inclusions into the hair shaft (Fernandez-Flores et al, 2019).…”

Section: Skin Aging At the Tissue Levelmentioning

confidence: 99%

“…As to the skin appendages, hair becomes thinner and on the scalp terminal hair follicles are gradually miniaturized (Fernandez-Flores et al, 2019). Most obvious, the natural hair color is lost due to a reduced transfer of pigment from follicular melanocytes to hair keratinocytes and air inclusions into the hair shaft (Fernandez-Flores et al, 2019). Sebum production decreases with age in particular in women after menopause.…”

Section: Skin Aging At the Tissue Levelmentioning

confidence: 99%

Autophagic Control of Skin Aging

Eckhart

Tschachler

Грубер

2019

Front. Cell Dev. Biol.

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The skin forms the barrier to the environment. Maintenance of this barrier during aging requires orchestrated responses to variable types of stress, the continuous renewal of the epithelial compartment, and the homeostasis of long-lived cell types. Recent experimental evidence suggests that autophagy is critically involved in skin homeostasis and skin aging is associated with and partially caused by defects of autophagy. In the outer skin epithelium, autophagy is constitutively active during cornification of keratinocytes and increases the resistance to environmental stress. Experimental suppression of autophagy in the absence of stress is tolerated by the rapidly renewing epidermal epithelium, whereas long-lived skin cells such as melanocytes, Merkel cells and secretory cells of sweat glands depend on autophagy for cellular homeostasis and normal execution of their functions during aging. Yet other important roles of autophagy have been identified in the dermis where senescence of mesenchymal cells and alterations of the extracellular matrix (ECM) are hallmarks of aging. Here, we review the evidence for cell type-specific roles of autophagy in the skin and their differential contributions to aging.

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“…Greying has been largely investigated at the hair follicle level. Enzymatic reactions required for melanin synthesis as well as environmental factors such as ultraviolet radiation and pollution generate large quantities of reactive oxygen species (ROS), including hydrogen peroxide (H 2 O 2 ) [1, 11, 12]. Numerous studies have pointed out the weakening of the antioxidant system and the progressive accumulation of ROS, in particular H 2 O 2 in grey hair follicles [11, 13–17].…”

Section: Introductionmentioning

confidence: 99%

“…A study from Wood and collaborators investigated in vivo grey and white hair shafts at the molecular level by Raman microspectroscopy and revealed an accumulation of H 2 O 2 resulting in amino acids oxidation such as methionine and consequently affecting the activity of enzymes involved in melanogenesis [18]. Some publications highlight that greying hair become thin, brittle, dull, less manageable and are usually hard to stain [1, 12, 19, 20]. These observations may be due to changes in hair fibres structure occurring in the course of greying.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the molecular signature of greying hair shafts

Vyumvuhore

Verzeaux

Gilardeau

et al. 2021

Intern J of Cosmetic Sci

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Objective Hair greying (i.e. canitie) is a physiological process occurring with the loss of melanin production and deposition within the hair shafts. Many studies reported the oxidation as the main biological process underlying this defect of pigmentation. Even though the overall appearance and biomechanical properties of hairs are reported to be altered with greying, there is a lack of information about molecular modifications occurring in grey hair shafts. The aim of this study was thus to investigate the molecular signature and associated changes occurring in greying hair shafts by confocal Raman microspectroscopy. Methods This study was conducted on pigmented, intermediate (i.e. grey) and unpigmented hairs taken from 29 volunteers. Confocal Raman microspectroscopy measurements were acquired directly on hair shafts. Results Automatic classification of Raman spectra revealed 5 groups displaying significant differences. Hence, the analysis of the molecular signature highlighted the existence of 3 sub‐groups within grey hair: light, medium and dark intermediate. Among molecular markers altered in the course of greying, this study identified for the first time a gradual modification of lipid conformation (trans/gauche ratio) and protein secondary structure (α‐helix/β‐sheet ratio), referring respectively to an alteration of barrier function and biomechanical properties of greying hair. Conclusion This study thus reports for the first time a highly specific molecular signature as well as molecular modifications within grey hair shaft.

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Histopathology of aging of the hair follicle

Cited by 36 publications

References 83 publications

Plasticity of Paneth cells and their ability to regulate intestinal stem cells

Plasticity of Paneth cells and their ability to regulate intestinal stem cells

Autophagic Control of Skin Aging

Investigation of the molecular signature of greying hair shafts

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