Plasticity of Paneth cells and their ability to regulate intestinal stem cells

Mei, Xianglin; Gu, Ming; Li, Meiying

doi:10.1186/s13287-020-01857-7

Cited by 36 publications

(28 citation statements)

References 127 publications

(179 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cells contribute to the integrity and cellular activities of the small intestinal crypts (Srugo et al, 2019) through secretion of growth factors (Spatz and Mills, 2019). Additionally, they regulate the intestinal microflora and have chemosensory functions (Vaishnava et al, 2008;Roura et al, 2019) and influence gut cell differentiation and maturation (Sato et al, 2011;Mei et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract

et al. 2021

View full text Add to dashboard Cite

The gastrointestinal tract (GIT) is the first point of contact for ingested substances and thus represents a direct interface with the external environment. Apart from food processing, this interface plays a significant role in immunity and contributes to the wellbeing of individuals through the brain-gut-microbiota axis. The transition of life from the in utero environment, to suckling and subsequent weaning has to be matched by phased development and maturation of the GIT; from an amniotic fluid occupancy during gestation, to the milk in the suckling state and ultimately solid food ingestion at weaning. This phased maturation of the GIT can be affected by intrinsic and extrinsic factors, including diet. Despite the increasing dietary inclusion of medicinal plants and phytochemicals for health benefits, a dearth of studies addresses their impact on gut maturation. In this review we focus on some recent findings mainly on the positive impact of medicinal plants and phytochemicals in inducing precocious maturation of the GIT, not only in humans but in pertinent animals. We also discuss Paneth cells as mediators and potential markers of GIT maturation.

show abstract

Section: Introductionmentioning

confidence: 99%

Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Moreover, further studies will be needed to determine if RIP140 could also play a role in the PC metaplasia associated with the detection of PC-like cells at the base of colonic crypts in inflammatory cecum and right colon [49,50]. In addition, PCs provide support to stem cells by secreting EGF, Wnt3a, and DLL4, while under injury conditions, PCs acquire stem features and generate all type of intestinal epithelial cells by activating Notch and Wnt signals [51]. Due to its negative effect on intestinal epithelial turnover after irradiation and on PC differentiation, determining whether RIP140 modulates the intestinal stem cell population could be an attractive proposition.…”

Section: Discussionmentioning

confidence: 99%

RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer

Gleizes

Triki

Bonnet

et al. 2021

Cancers

View full text Add to dashboard Cite

RIP140 is a major transcriptional coregulator of gut homeostasis and tumorigenesis through the regulation of Wnt/APC signaling. Here, we investigated the effect of RIP140 on Paneth cell differentiation and its interplay with the transcription factor SOX9. Using loss of function mouse models, human colon cancer cells, and tumor microarray data sets we evaluated the role of RIP140 in SOX9 expression and activity using RT-qPCR, immunohistochemistry, luciferase reporter assays, and GST-pull down. We first evidence that RIP140 strongly represses the Paneth cell lineage in the intestinal epithelium cells by inhibiting Sox9 expression. We then demonstrate that RIP140 interacts with SOX9 and inhibits its transcriptional activity. Our results reveal that the Wnt signaling pathway exerts an opposite regulation on SOX9 and RIP140. Finally, the levels of expression of RIP140 and SOX9 exhibit a reverse response and prognosis value in human colorectal cancer biopsies. This work highlights an intimate transcriptional cross-talk between RIP140 and SOX9 in intestinal physiopathology.

show abstract

“…Coculturing of sorted Paneth cells with ISCs dramatically enhances intestinal organoid formation and growth [12], whereas Paneth cell defects results in ISC dysfunction and leads to an inhibition of intestinal mucosal growth [12,27]. In the case of Paneth cell ablation, enteroendocrine and Tuft cells and intestinal stromal cells can also support ISC function [11,45,46].…”

Section: Paneth Cells Regulate Intestinal Mucosal Growth By Interacting With Intestinal Stem Cellsmentioning

confidence: 99%

Regulation of Paneth Cell Function by RNA-Binding Proteins and Noncoding RNAs

Chung

Xiao

Jaladanki

2021

Cells

View full text Add to dashboard Cite

Paneth cells are specialized intestinal epithelial cells that are located at the base of small intestinal crypts and play a vital role in preserving the gut epithelium homeostasis. Paneth cells act as a safeguard from bacterial translocation across the epithelium and constitute the niche for intestinal stem cells in the small intestine by providing multiple niche signals. Recently, Paneth cells have become the focal point of investigations defining the mechanisms underlying the epithelium-microbiome interactions and pathogenesis of chronic gut mucosal inflammation and bacterial infection. Function of Paneth cells is tightly regulated by numerous factors at different levels, while Paneth cell defects have been widely documented in various gut mucosal diseases in humans. The post-transcription events, specific change in mRNA stability and translation by RNA-binding proteins (RBPs) and noncoding RNAs (ncRNAs) are implicated in many aspects of gut mucosal physiology by modulating Paneth cell function. Deregulation of RBPs and ncRNAs and subsequent Paneth cell defects are identified as crucial elements of gut mucosal pathologies. Here, we overview the posttranscriptional regulation of Paneth cells by RBPs and ncRNAs, with a particular focus on the increasing evidence of RBP HuR and long ncRNA H19 in this process. We also discuss the involvement of Paneth cell dysfunction in altered susceptibility of the intestinal epithelium to chronic inflammation and bacterial infection following disrupted expression of HuR and H19.

show abstract

Plasticity of Paneth cells and their ability to regulate intestinal stem cells

Cited by 36 publications

References 127 publications

Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract

Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract

RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal Cancer

Regulation of Paneth Cell Function by RNA-Binding Proteins and Noncoding RNAs

Contact Info

Product

Resources

About