Microangiopathic Ulcers of the Lower Extremities: A Daily Challenge

Papi, Massimo

doi:10.1177/1534734606288814

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…[1][2][3][4] We are deeply obliged to the founding editor, Professor Raj Mani, for his exemplary and pioneer work over many years. Among the journal's contents, diabetic foot disease, [5][6][7] vascular disease and related technology, 8,9 as well as various other ulcers 10,11 are of paramount importance, and so they will be in the future.…”

Section: Editorialmentioning

confidence: 99%

Progress in Wound Healing: Wisdom Not Consumed in Confidence?

Παπάνας

Papi²

2019

The International Journal of Lower Extremity Wounds

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Section: Editorialmentioning

confidence: 99%

Progress in Wound Healing: Wisdom Not Consumed in Confidence?

Παπάνας

Papi²

2019

The International Journal of Lower Extremity Wounds

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“…It implies that systemic therapies should be carefully evaluated because they may have contradictory aims. 1 Vasculitic ulcers are a major part of inflammatory MU. They have been reported to account for 5% to 15% of all leg ulcers.…”

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confidence: 99%

Future of Biologics in Healing Angiopathic Wounds

Papi¹,

Mani

2018

The International Journal of Lower Extremity Wounds

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“…The result may be frequently a chronic ulcer that requires a histologic confirmation (Figures 4-8). 1,2 Nonhealing vasculitic ulcers may be explained with the persistent presence of activated neutrophils and lymphomonocytes and the consequent local inflammatory status that they provoke. 3-5 PG and CTD account for a minor number of angiopathic inflammatory ulcers.…”

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confidence: 99%

Biologics in Microangiopathic Wounds

Papi¹,

Papi

2018

The International Journal of Lower Extremity Wounds

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Pathogenetically, we can distinguish 2 main groups of microangiopathic ulcers (MUs): (1) ulcers due to inflammatory microangiopathy, mainly including cutaneous small and medium vessel vasculitis (VS), pyoderma gangrenosum (PG), and connective tissue disease (CTD), and (2) ulcers due to occlusive microangiopathy. The group of microangiopathic occlusive ulcers is more heterogeneous and includes very poorly understood disturbances (such as livedo vasculopathy and calciphylaxis), still-debated ulcerative diseases (such as hypertensive ulcers), recently described iatrogenic ulcers (ie, during hydroxyurea therapy), ulcers due to cryoprotein deposition, ulcers linked to clot formation (ie, antiphospholipid antibodies) or microembolization (ie, cholesterol emboli and injected substances), and metabolic anomalies. These conditions can induce thromboses or anatomo-functional occlusion of cutaneous microvessels (Figures 1-3). A consistent number of inflammatory MUs are the result of skin necrosis due to a VS. VS is an immunologically mediated angiocentric inflammation, characterized by neutrophils and lymphomonocyte infiltration of the vessel wall, which induces fibrinoid necrosis, reduction of blood supply, and ischemia. The result may be frequently a chronic ulcer

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Microangiopathic Ulcers of the Lower Extremities: A Daily Challenge

Cited by 6 publications

References 8 publications

Progress in Wound Healing: Wisdom Not Consumed in Confidence?

Progress in Wound Healing: Wisdom Not Consumed in Confidence?

Future of Biologics in Healing Angiopathic Wounds

Biologics in Microangiopathic Wounds

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