Microanalysis of Selected NSAIDs Using the Spectrophotometric Method

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the group of drugs most commonly used in medicine. They are available over the counter to treat fevers and pains of various origins. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for drug quality control, pharmacodynamic and pharmacokinetic studies. This article presents the spectrophotometric method that was used to analyze selected drugs from the NSAID group. The conditions for the determination of selected coxibs and oxicams in the UV range with the use of microplates have been developed. The presented procedure has been validated in accordance with the requirements, guaranteeing reliable results. The obtained results give the basis for the conclusion that the method can be successfully used in the quality control of pharmaceutical preparations with a small amount of available sample.

تقنية كرموتوغرافيا السائل ذات الاداء العالي ذوالطور العكسي مع كاشف الاشعة الفوق البنفسجية لتقدير ادوية الايبو بروفين والتنوكسيكام في الصورة النقية و الاقراص الدوائية

“…TNX obstructs the actions of COX enzymes, the chemicals responsible for pain and inflammation. Various techniques have been employed to determine the levels of TNX, including HPLC 15 , UV 16 , fluorescence 17 , flow injection 18 , and ionpair 19 spectrophotometry, electro analytical 20 , voltammetry 21 , X-ray 22 , scanning electron microscopy (SEM), X-ray diffraction, dynamic light scattering (DLS), Fourier transform infrared (FTIR) 23 , photo catalysis 24 , and immunochromatographic strip with colloidal gold 25 .…”

Extraction-Free Spectrophotometric Determination of Meloxicam Using Bromothymol Blue

“…There is a wide choice of various analytical techniques for the assay of meloxicam in pharmaceuticals available in the literature [8][9][10][11][12][13][14][15][16][17][18]. Spectrophotometry is one of the most commonly used methods for the determination of this drug.…”

Spectrophotometric Determination of Naproxen Using Chitosan Capped Silver Nanoparticles in Pharmaceutical Formulation

“…It is an important member of the family of 2-aryl propionic acid derivatives; which commonly used for reducing moderate to severe pain, fever, inflammation, and stiffness owing to arthritis, gout, injury (such as fractures), tonsillitis and bursitis. It has also recently been reported that naproxen is *Corresponding Author Institutional Email: Afsharalihosseini@iauctb.ac.ir (A. Alihosseini) effectively used in preventing the progression of bladder cancer [3] Naproxen inhibits COX-1 and COX-2 enzymes can prevent the biosynthesis of prostaglandins [4]. Naproxen (NP) is widely used to treat acute to chronic pain most commonly in veterinary and human medicine because it is available without a prescription.…”