‘Microalbuminuric anaemia’—The relationship between haemoglobin levels and albuminuria in diabetes

Adetunji, O; Mani, Hamidreza; Olujohungbe, Adebayo; Abraham, Kottarathil A.; Gill, Geoff

doi:10.1016/j.diabres.2009.04.028

Cited by 29 publications

(35 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decrease of hemoglobin concentration in the absence of significant excretory dysfunction has also been demonstrated in other study [20]. The decrease in hemoglobin in macroalbuminuria as compared to normoalbuminuria cannot be explained by reduced renal function as there was no significant difference in eGFR between the groups (Table 2).…”

Section: Discussionsupporting

confidence: 79%

Soluble α-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes

et al. 2014

View full text Add to dashboard Cite

ObjectiveAlthough α-klotho is known as an anti-aging, antioxidant, and cardio-renal protective protein, the clinical implications of soluble α-klotho levels in patients with diabetes have not been evaluated. Therefore, this study evaluated whether plasma and urinary α-klotho levels are associated with albuminuria in kidney disease in diabetes.Research Design and MethodsA total of 147 patients with type 2 diabetes and 25 healthy control subjects were enrolled. The plasma and urine concentrations of α-klotho were analyzed by enzyme-linked immunosorbent assay.ResultsPlasma α-klotho (572.4 pg/mL [95% CI, 541.9–604.6 pg/mL] vs. 476.9 pg/mL [95% CI, 416.9–545.5 pg/mL]) and urinary α-klotho levels (59.8 pg/mg creatinine [95% CI, 43.6–82.0 pg/mg creatinine] vs. 21.0 pg/mg creatinine [95% CI, 9.7–45.6 pg/mg creatinine]) were significantly higher in diabetic patients than non-diabetic controls. Among diabetic patients, plasma α-klotho concentration was inversely associated with albuminuria stages (normoalbuminuria, 612.6 pg/mL [95% CI, 568.9–659.6 pg/mL], microalbuminuria, 551.8 pg/mL [95% CI, 500.5–608.3 pg/mL], and macroalbuminuria, 505.7 pg/mL [95% CI, 439.7–581.7 pg/mL] (p for trend = 0.0081), while urinary α-klotho levels were remained constantly high with increasing urinary albumin excretion.ConclusionsSoluble α-klotho levels in plasma and urine may be novel and useful early markers of diabetic renal injury.

show abstract

Section: Discussionsupporting

confidence: 79%

Soluble α-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes

et al. 2014

View full text Add to dashboard Cite

show abstract

“…This also highlighted that anemia may occur early in diabetic nephropathy before any significant decline in eGFR. Previous studies have also found an increased prevalence of anemia with declined renal function and elevated albuminuria [15,16]. Thomas have anemia as those with normal renal function (CCr >90 mL/min/1.73 m 2 ).…”

Section: Discussionmentioning

confidence: 94%

Genetic disposition and modifiable factors independently associated with anemia in patients with type 2 diabetes mellitus

Chiou

Lee

Wang

et al. 2015

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

“…Anemia can occur in diabetic patients without underlying severe chronic renal disease. The cause of this non-renal diabetic anemia remains largely unknown (9).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Neutrophil/Lymphocyte Ratio and Albuminuria in Diabetic Patients

Ünal¹,

Koçyiğit²,

I³

et al. 2015

Turk Neph Dial Transpl

View full text Add to dashboard Cite

OBJectIVe: We aimed to investigate whether there is a relationship between neutrophil/lymphocyte (N/L) ratio and albuminuria in diabetic patients. MAterIAl and MetHODS:This study included 170 diabetic patients. The patients were divided 3 groups according to urinary albumin creatinine ratio (UACR). The first group included patients with normoalbuminuria (UACR <0.030). The second group included patients with moderately increased albuminuria (0.030-0.300), whereas the third group consisted of patients with severely increased albuminuria (UACR>0.300).reSultS: N/L ratio was 1.83, 2.23, and 2.77 in first, second, and third group, respectively. It was meaningfully higher in third group when compared with two groups. Although there was no statistically meaningful difference between the first group and the second group, it was higher in the second group than that in the first group. The hemoglobin concentration was 14.3 ±1.6 g/dl, 13.6 ± 1.8 g/dl, and 12.4 ± 1.8 g/dl in the first, second, and third group, respectively. It was significantly lower in the third group when compared with other groups. However, there was no meaningful difference between the first group and the second group. Presence of anemia increased step-wise from the first group to the third group (8.7%, 21.3%, and 48.1%, respectively).cOncluSIOn: N/L ratio and anemia associate closely with albuminuria in diabetic patients.

show abstract

‘Microalbuminuric anaemia’—The relationship between haemoglobin levels and albuminuria in diabetes

Cited by 29 publications

References 14 publications

Soluble α-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes

Soluble α-Klotho as a Novel Biomarker in the Early Stage of Nephropathy in Patients with Type 2 Diabetes

Genetic disposition and modifiable factors independently associated with anemia in patients with type 2 diabetes mellitus

Relationship Between Neutrophil/Lymphocyte Ratio and Albuminuria in Diabetic Patients

Contact Info

Product

Resources

About